Diluant physiologique phenole

Diluant physiologique phenole Medicine

Overdose

Symptoms:

The symptoms of overdosage after submucosal injection of Oily Diluant Physiologique Phenole are not known, but are likely to be similar to symptoms observed after excessive exposure to Diluant Physiologique Phenole in other preparations. Absorption of Diluant Physiologique Phenole after application of dilute Diluant Physiologique Phenole solutions to extensive wounds has resulted in abdominal pains, dizziness, methaemoglobinaemia, haemoglobinurea, cyanosis, cardiac arrhythmias, ECG abnormalities, and may result in respiratory failure, circulatory failure, coma and death.

Treatment: There is no specific antidote for actute Diluant Physiologique Phenole overdose. Treatment of overdose is symptomatic and supportive. If the product has been swallowed, empty the stomach by aspiration and lavage, taking care to avoid perforation, before carrying out the above procedure.

Contraindications

Oily Diluant Physiologique Phenole Injection, BP is contraindicated in patients who are hypersensitive to Diluant Physiologique Phenole, nuts and in particular almond oil or any component of the product. It should not be used over large areas, since sufficient amounts may be absorbed to give rise to toxic symptoms. Oily Diluant Physiologique Phenole Injection, BP is also contraindicated in neonates and children.

Incompatibilities

None stated

Undesirable effects

General disorders and administration site conditions:

Pyrexia

Pain

Discomfort

Irritation

Ulcer

Tissue necrosis

Immune system disorders:

Hypersensitivity

Nervous system disorders:

Dizziness

Hepatobiliary disorders:

Hepatitis

Infections and infestations:

Abscess

Prostatic abscess

Necrotizing fasciitis

Retroperitoneal sepsis

Renal and urinary disorders:

Dysuria

Urinary incontinence

Reproductive system and breast disorders:

Impotence

Preclinical safety data

Not applicable

Therapeutic indications

Analgesic sclerosing agent in the treatment of internal haemorrhoids

Pharmacodynamic properties

The injection produces submucosal fibrosis, fixing the mucosa to the underlying muscle.

Pharmacokinetic properties

Not applicable

Name of the medicinal product

Diluant Physiologique Phenole

Qualitative and quantitative composition

Phenol

Special warnings and precautions for use

For submucosal injection only. Not for intrathecal use. Care should also be taken to avoid accidental intravenous injection. The injection may cause severe pain if it is too close to the anal verge. Complications of therapy can include local ulceration and sterile abscess formation. These complications may be serious following a misplaced injection (eg prostatic abscess). Care in choosing the correct site of injection is mandatory.

Effects on ability to drive and use machines

Not applicable

Dosage (Posology) and method of administration

By submucosal injection

Adults and the elderly

2 - 3 ml injected at the base of the haemorrhoid. Several sites may be injected but the maximum total at any one time is 10 ml.

Children

The use of oily Diluant Physiologique Phenole injection BP is contraindicated in children and neonates.

Special precautions for disposal and other handling

None