Symptoms:
The symptoms of overdosage after submucosal injection of Oily Diluant Physiologique Phenole are not known, but are likely to be similar to symptoms observed after excessive exposure to Diluant Physiologique Phenole in other preparations. Absorption of Diluant Physiologique Phenole after application of dilute Diluant Physiologique Phenole solutions to extensive wounds has resulted in abdominal pains, dizziness, methaemoglobinaemia, haemoglobinurea, cyanosis, cardiac arrhythmias, ECG abnormalities, and may result in respiratory failure, circulatory failure, coma and death.
Treatment: There is no specific antidote for actute Diluant Physiologique Phenole overdose. Treatment of overdose is symptomatic and supportive. If the product has been swallowed, empty the stomach by aspiration and lavage, taking care to avoid perforation, before carrying out the above procedure.
Oily Diluant Physiologique Phenole Injection, BP is contraindicated in patients who are hypersensitive to Diluant Physiologique Phenole, nuts and in particular almond oil or any component of the product. It should not be used over large areas, since sufficient amounts may be absorbed to give rise to toxic symptoms. Oily Diluant Physiologique Phenole Injection, BP is also contraindicated in neonates and children.
None stated
General disorders and administration site conditions:
Pyrexia
Pain
Discomfort
Irritation
Ulcer
Tissue necrosis
Immune system disorders:
Hypersensitivity
Nervous system disorders:
Dizziness
Hepatobiliary disorders:
Hepatitis
Infections and infestations:
Abscess
Prostatic abscess
Necrotizing fasciitis
Retroperitoneal sepsis
Renal and urinary disorders:
Dysuria
Urinary incontinence
Reproductive system and breast disorders:
Impotence
Not applicable
Analgesic sclerosing agent in the treatment of internal haemorrhoids
The injection produces submucosal fibrosis, fixing the mucosa to the underlying muscle.
Not applicable
For submucosal injection only. Not for intrathecal use. Care should also be taken to avoid accidental intravenous injection. The injection may cause severe pain if it is too close to the anal verge. Complications of therapy can include local ulceration and sterile abscess formation. These complications may be serious following a misplaced injection (eg prostatic abscess). Care in choosing the correct site of injection is mandatory.
Not applicable
By submucosal injection
Adults and the elderly
2 - 3 ml injected at the base of the haemorrhoid. Several sites may be injected but the maximum total at any one time is 10 ml.
Children
The use of oily Diluant Physiologique Phenole injection BP is contraindicated in children and neonates.
None
