For all dosage forms
Infections caused by sensitive strains of microorganisms:
upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis),
lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia),
urinary tract infections (e.g. cystitis, urethritis, pyelonephritis),
in gynecology,
skin and soft tissue, including human and animal bites,
bone and connective tissue,
bile ducts (cholecystitis, cholangitis),
odontogenic.
Amoxiclav®
For powder for preparation of solution for intravenous administration in addition
abdominal infections,
sexually transmitted infections (gonorrhea, mild chancre),
prevention of infections after surgical interventions.
The drug Augmentin® CP is indicated for the treatment of bacterial infections of the following localizations caused by microorganisms sensitive to the combination of amoxicillin with clavulanic acid:
respiratory tract infections, such as community-acquired pneumonia, exacerbation of chronic bronchitis, acute bacterial sinusitis, usually caused by Streptococcus pneumoniae (including penicillin-resistant strains), Haemophilus influenzae1, Moraxella catarrhalis1 and Streptococcus pyogenes,
prevention of local infections after surgery in dentistry.
1 Some strains of these bacteria produce beta-lactamases, which makes them insensitive to amoxicillin monotherapy.
Infections caused by amoxicillin-sensitive microorganisms can be treated with Augmentin® CP, since amoxicillin is one of its active ingredients. The drug Augmentin® CP is also indicated for the treatment of mixed infections caused by microorganisms sensitive to amoxicillin, as well as beta-lactamase-producing microorganisms sensitive to the combination of amoxicillin with clavulanic acid.
The drug Augmentin® CP demonstrated efficacy against strains S. pneumoniae, resistant to penicillin (strains with MPC ≥2 mg/l).
Preparations containing a combination of amoxicillin with clavulanic acid should be used in accordance with the Russian guidelines for antibiotic therapy and regional data on the sensitivity of pathogens to the combination of amoxicillin with clavulanic acid.
The sensitivity of bacteria to the combination of amoxicillin with clavulanic acid varies depending on the region and over time. Where possible, local sensitivity data should be taken into account. If necessary, microbiological samples should be collected and analyzed for bacteriological sensitivity.
It is also used for the prevention of infections that are associated with major surgical operations on the gastrointestinal tract, in the pelvic area, head and neck, on the heart, kidneys, and bile ducts.
Demoxiclave
Amoxicillin, Clavulanic
Amoxiclav
The drug Amoxiclav
Children with a body weight of 40 kg or more should be given the same doses as adults. For children aged less than 6 years, it is more preferable to take a suspension of the drug Amoxiclav.
Adults and children over 12 years of age (or >40 kg of body weight)
The usual dose in the case of mild and moderate infection is 1 tab. 250 125 mg every 8 hours or 1 tab. 500 125 mg every 12 hours, in the case of severe infection and respiratory tract infections-1 tab. 500 125 mg every 8 hours or 1 tab. 875 125 mg every 12 hours.
Dosage for odontogenic infections
1 tab. 250 125 mg every 8 hours or 1 tab. 500 125 mg every 12 hours for 5 days.
Patients with impaired renal function
Dose adjustment is based on the maximum recommended dose of amoxicillin and is carried out taking into account the values of Cl creatinine:
- with anuria, the interval between dosing should be increased to 48 hours or more,
| Creatinine clearance | |
| >30 ml / min | |
| 1 table. 500 125 mg 1 time per day or 1 table. 250 125 mg (for mild and moderate infection) 1 time per day | |
| Hemodialysis | 1 table 500 125 mg or 2 table 250 125 mg every 24 hours 1 table 500 125 mg or 2 table 250 125 mg during dialysis and at the end of the dialysis session (due to a decrease in serum concentrations of amoxicillin and clavulanic acid) |
Taking the drug Amoxiclav it should be carried out with caution. It is necessary to conduct regular monitoring of liver function.
Powder for preparation of suspension for oral administration
Inside
The dosing of the drug Amoxiclav® dosage pipette-calculation of single doses for the treatment of infections in newborns and children up to 3 months (Table 3).
Table 3
| 2 | 2,6 | 3,4 | 4 | ||||||||||||
| Suspension 156.25, ml (2 times a day) | 1,2 | 1,6 | 2,8 | ||||||||||||
| 0,6 | 0,7 | 0,8 | 1,1 | 1,3 | 1,4 |
Children older than 3 months — from 20 mg / kg for mild and moderate infections to 40 mg / kg for severe infections and lower respiratory tract infections, otitis media, sinusitis (amoxicillin) per day, divided into 3 doses (every 8 hours).
The dosing of the drug Amoxiclav®
Table 4
| 5 | 12 | 14 | 18 | |||||||||||||||
| 2,7 | 2,9 | 3,7 | 4,3 | 5,6 | ||||||||||||||
| Suspension 312,5, ml (3 times a day) | 0,8 | 1,2 | 2,7 | |||||||||||||||
| 8,8 | 9,3 | |||||||||||||||||
| 3,1 | 3,2 | 3,3 | 4 | 4,1 | 4,5 | 4,8 |
Table 5
| Body weight, kg | 10 | |||||||||||||||||
| 4,8 | 9,1 | 10,7 | ||||||||||||||||
| 2,1 | 2,9 | 5,1 | 5,3 | 5,9 | ||||||||||||||
| 26 | 36 | 37 | ||||||||||||||||
| 16 | 17,6 | 20,3 | ||||||||||||||||
| 6,1 | 8,3 | 9,1 |
dosage spoon (in the absence of a dosage pipette) - recommended doses of suspensions depending on the child's body weight and the severity of the infection (Table 6).
| Age (approximately) | Mild/moderate course | ||||
| 1-2 years | |||||
| 12–15 | |||||
| 3 × 4.5 ml | |||||
| 3 × 6.5 ml | |||||
| 3-12 months | |||
The maximum daily dose of amoxicillin is 6 g for adults and 45 mg/kg for children.
In patients with impaired renal function, the dose should be adjusted based on the maximum recommended dose of amoxicillin.
With a creatinine Cl of 10-30 ml / min, the recommended dose is 15/3. 75 mg / kg 2 times a day (maximum 500/125 mg 2 times a day).
Table 8
Shake vigorously before use!
After taking the drug, it is recommended to rinse the dosage pipette with boiled water.
Children:
) every 12 hours.
- 30 mg / kg (in terms of the entire drug Amoxiclav
| 25 mg / 5 mg per 1 kg every 24 hours plus a dose of 12.5 mg/2.5 mg per 1 kg at the end of the dialysis session (due to a decrease in the concentration of amoxicillin and clavulanic acid in the serum) |
For patients with renal insufficiency, the dose and / or interval between injections of the drug should be adjusted depending on the degree of insufficiency:
. In peritoneal dialysis, dose adjustment is not required.
do not mix with dextrose, dextran, or sodium bicarbonate solutions.
The dosage regimen is set individually depending on the age, body weight, kidney function of the patient and the severity of the infection.
For the treatment of severe infections and respiratory infections — 1 tablet (500 mg/125 mg) every 8 hours (3 times a day).
| 500 mg / 125 mg every 24 hours, plus 500 mg/125 mg during the dialysis session, with repeated use at the end of the dialysis session (since plasma concentrations of amoxicillin and clavulanic acid decrease) |
®
Patients with impaired renal function. In patients with a creatinine Cl of more than 30 ml/min, there is no need for dose adjustment.
Such patients should take the drug at a dosage of 500 mg/125 mg after a dose adjustment corresponding to the level of Cl creatinine.
The maximum daily dose of clavulanic acid for adults (in the form of potassium clavulanate) is 600 mg, for children-10 mg/kg / day.
The SRS have a dividing groove that allows them to be broken in half for ease of ingestion, but not to reduce the dose: both halves must be taken simultaneously. The recommended dose of the drug is 2 tablets. 2 times a day.
Respiratory tract infections: 2 table. 2 times a day for 7-10 days, including the following diseases:
Children under 3 months: 30 mg / kg every 12 hours in premature infants and newborns, then the interval between injections is reduced to 8 hours.
