and methotrexate increases the toxicity of methotrexate.
In patients receiving mycophenolate mofetil, after the start of the combination of amoxicillin with clavulanic acid, there was a decrease in the concentration of the active metabolite — mycophenolic acid, before taking the next dose of the drug by approximately 50%. Changes in this concentration may not accurately reflect the overall changes in mycophenolic acid exposure.
Simultaneous use of the drug Augmentin
®
Amoxiclav
Amoxiclav
prevention of local infections after surgery in dentistry.
®
, resistant to penicillin (strains with MPC ≥2 mg/l).
Clavulanic acid is a beta-lactam structurally related to penicillins. It inhibits certain beta-lactamases, thereby preventing the inactivation of amoxicillin and expanding its range of activity, including bacteria that are usually resistant to amoxicillin, as well as other penicillins and cephalosporins. By itself, clavulanic acid does not have a clinically significant antibacterial effect.
it has a bactericidal effect
Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
in the blood plasma after bolus injection at a dose of 1.2 g (1000 200 mg) of the drug is 105.4 mg/l - for amoxicillin and 28.5 mg / l — for clavulanic acid.
Metabolism
Amoxicillin, Clavulanic
The drug Amoxiclav
dosage pipette-calculation of single doses for the treatment of severe infections in children older than 3 months (at the rate of 40 mg / kg / day (according to amoxicillin) (Table 5).
Table 5
The maximum daily dose of amoxicillin for adults is 6 g, for children-45 mg / kg / day.
| 5 kg | ||
