Acute overdose with topical application of the drug Clotrimazolum GSK is unlikely and does not lead to a life-threatening situation.
Hypersensitivity to the components of the drug.
Hypersensitivity, pregnancy (I trimester).
When used concomitantly with amphotericin B, nystatin, the activity of clotrimazole may decrease.
The effectiveness reduces nystatin.
The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted — redness of the oral mucosa, a burning and tingling sensation at the site of application of the drug, urticaria.
If irritation occurs, the drug should be discontinued.
Allergic reactions: hyperemia, itching, rash.
Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.
The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.
To clotrimazole sensitive dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of multi-colored lichen Pityriasis versicolor and the causative agent of erythrasma.
It has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as in relation to Trichomonas vaginalis.
It has a wide spectrum of action. Active against dermatophytes, yeast fungi of the genus Candida, Corynebacterium minutissimum, Staphylococcus spp., Streptococcus spp., Trichomonas.
When applied topically, clotrimazole adsorption from the mucous membranes is negligible.
It is characterized by a high penetrating power. The concentration in the epidermis is higher than in the dermis and subcutaneous tissue. It has practically no systemic effect.
†Do not use if you have abdominal pain, fever, or a foul-smelling vaginal discharge. You may have a condition which is more serious than a yeast infection. Contact your doctor immediately.
†Do not use if this is your first experience with vaginal itch and discomfort. See your doctor.
†If there is no improvement within 3 days, you may have a condition other than a yeast infection. Stop using this product and see your doctor.
†If you may have been exposed to the human immunodeficiency virus (HIV, the virus that causes AIDS) and are now having recurrent vaginal yeast infections, especially infections that don†t clear up easily with proper treatment, see your doctor promptly to determine the cause of your symptoms and to receive proper medical care.
†If symptoms recur within a 2 month period, contact your doctor.
†Do not use during pregnancy except under the advice and supervision of a doctor.
†This medication is for use in the vaginal and vulvar areas only. It is not for use in the mouth or the eyes. In case accidentally swallowed, seek professional assistance or contact a Poison Control Center immediately.
† Keep this and all drugs out of reach of children. This product is not to be used in children less than 12 years of age.
If you have questions about Clotrimazole Vaginal Cream or vaginal yeast infections, contact your doctor.
PRECAUTIONSNo information provided.
See PATIENT INFORMATION section.
