Acute overdose due to topical application of drug Kandazole is unlikely and does not lead to life-threatening situations。
When used at the same time as angotericin B and nistatin, the durability of clotrimazole may be reduced。
Reduces the effectiveness of nistatin。
This drug is usually well tolerated。 Rarely, hypersensitivity to the ingredients of a drug focuses on allergic reactions such as redness of the oral mucosa, burning and tingling at the site of application of the drug, and urticaria。
If irritation occurs, the drug should be discontinued。
Allergic reaction: bloodshed, itching, rash.
Clotrimazole is an imidazole derivative and a wide range of antifungal agents。
The antifungal effect violates the synthesis of ergosterol, which is part of the cell membrane of a fungus, causes changes in its structure and properties, and results in cytolysis。
Against clotrimazole-sensitive skin filamentous fungi and yeast-like fungi (genus) Candida, Torlopsis-Grabrata, Rhodotrula), mold fungi, and multicolored moss causative substances Pitilia Sith-Versicolor And the causative agent of Eritrasma。
It has antibacterial effects against Gram-positive (Staphylococcus and Streptococcus) and Gram-negative bacteria (Bacteroides, Gardnerera-Vaginaris) Even in relation to Trichomonas-Vaginaris
It has a wide range of effects。 It is resistant to the situation, Candida fungi, corynebacterium Minutissimum, and staphylocococcal spp。, Streptococcus。, Trichomonas
When applied locally, clotrimazole adsorption from the mucous membrane is negligible。
It is characterized by high penetration。 Concentrations in the epidermis are higher than those in the dermis and subcutaneous tissues。 It has virtually no systemic effect。
