Acute overdose is unlikely, but with excessive or prolonged use of drugs, a chronic overdose is possible, accompanied by signs of hypercorticism: hyperglycemia, glucosuria, reversible suppression of the function of the adrenal cortex, the manifestation of Cushing's syndrome.
Treatment: symptomatic therapy. In the case of chronic toxic effects, gradual withdrawal of the drug is recommended.
Symptoms: excessive or prolonged use of corticosteroids for topical use can lead to suppression of pituitary and adrenal function, up to the development of secondary adrenal insufficiency.
Treatment: symptomatic therapy, including correction of water-electrolyte balance. Gradual withdrawal of the drug.
Hypersensitivity.
Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chickenpox, herpes simplex, skin post-vaccination reactions, open wounds, lactation and children under 1 year of age, in addition to the drug Acriderm®: trophic ulcers of the lower leg, rosacea, vulgar acne, additionally for the drug Acriderm® GC: in the treatment of external otitis media — perforation of the tympanic membrane, in addition to the drug Acriderm® SC: perioral dermatitis.
hypersensitivity to any of the components of the drug,
keratitis caused by the herpes simplex virus (tree keratitis),
viral diseases of the cornea and conjunctiva (for example, chickenpox),
mycobacterial and fungal infections of the eye or ear,
trachoma,
conditions accompanied by thinning of the cornea and sclera (for example, after removal of a foreign body from the cornea),
absence or perforation of the eardrum,
children under 8 years of age,
pregnancy,
lactation period (due to lack of information),
wearing soft contact lenses (due to the presence of benzalkonium chloride in the composition).
With caution:
open-angle glaucoma, high-grade myopia,
family history of diabetes mellitus,
infection caused by the herpes simplex virus.
Interaction of the drug with other drugs was not revealed.
Burning, itching, irritation and dryness of the skin, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, systemic side effects, including suppression of the adrenal cortex. When using occlusive dressings — maceration and atrophy of the skin, secondary infection, sweating, striae. In children-depression of the hypothalamic-pituitary-adrenal system, Cushing's syndrome, linear growth retardation, lag in weight gain, increased intracranial pressure.
With topical application of GCS, there may be: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. With prolonged use, as well as the use of occlusive dressings — skin maceration, secondary infection, skin atrophy, sweating, purpura.
Acriderm®
When applied to large areas of the body, mainly in children, systemic side effects of GCS may occur (hyperglycemia, glucosuria, reversible suppression of the function of the adrenal cortex, the manifestation of Cushing's syndrome).
Acriderm® GHENT
Acriderm® GC
When applied to large body surfaces, mainly in children, systemic side effects of corticosteroids (hyperglycemia, glucosuria, reversible suppression of the function of the adrenal cortex, the manifestation of Cushing's syndrome) and gentamicin (nephrotoxic and ototoxic effects) may occur.
Acriderm® SK
When applied to large areas of the body, mainly in children, systemic side effects of corticosteroids and salicylates may occur.
If you experience side effects that are not described in the instructions, you should consult a doctor.
There may be a short-term burning sensation, itching or dryness of the skin at the site of application.
Adverse events associated with the effect of corticosteroids on the eyes: increased intraocular pressure, glaucoma, optic nerve damage, decreased acuity and narrowing of the visual field, development of posterior subcapsular cataracts, delayed wound healing, the appearance of filtering bubbles after cataract surgery, the development of secondary eye infection (for example Herpes zoster), acute anterior uveitis, perforation of the cornea and sclera, mydriasis, disturbance of accommodation of the eye, ptosis.
When using antibiotics for the treatment of the eyes, allergic reactions may develop. Transient eye irritation has been reported due to the use of gentamicin sulfate.
Psoriasis, contact and atopic dermatitis (children's eczema, allergic dermatitis), neurodermatitis, lichen planus, eczema (monetoid, hand, eczema), intertriginous dermatitis, dyshidrosis, seborrheic dermatitis, exfoliative and solar dermatitis, itching of the anus and external genitals.
Acriderm®
Allergic skin diseases (including acute, subacute and chronic contact dermatitis, occupational dermatitis, seborrheic dermatitis, atopic dermatitis, solar dermatitis, neurodermatitis, itching, dyshidrotic dermatitis, eczema), acute and chronic forms of non-allergic dermatitis, psoriasis.
Acriderm® GHENT
Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, children's, coin-shaped), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, itching.
Acriderm® GC
Treatment of dermatoses complicated by primary and / or secondary infection, pityriasis, limited and diffuse neurodermatitis, dermatomycosis (including inguinal, foot) caused by pathogens sensitive to the drug.
Acriderm® SK
Local treatment of dermatoses accompanied by hyperkeratosis: psoriasis, limited and diffuse neurodermatitis, lichen planus, eczema, dyshidrotic dermatitis, ichthyosis and ichthyosiform changes.
staphylococcal blepharoconjunctivitis, keratoconjunctivitis, secondarily infected conjunctivitis,
blepharitis, keratitis, episcleritis, dacryocystitis, barley (meibomitis),
injuries to the anterior part of the eye resulting from foreign bodies, radiation exposure, thermal and chemical burns, as well as in the postoperative period,
acute and chronic otitis externa, secondarily infected diseases of the external auditory canal,
eczema, seborrheic and contact dermatitis.
The corticosteroid betamethasone dipropionate inhibits the accumulation of white blood cells, the release of lysosomal enzymes and pro-inflammatory mediators in the focus of inflammation, inhibits phagocytosis, reduces vascular-tissue permeability, and prevents the formation of inflammatory edema.
Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides. It has a bactericidal effect against pathogens of primary and secondary bacterial infections of the skin. It is active against Gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, gram-positive bacteria: Streptococcus spp. (sensitive strains of beta-and alpha-hemolytic streptococcus group A), Staphytococcus spp. (coagulase-positive, coagulase-negative, and some penicillinase-producing strains). It is inactive against anaerobes, fungi and viruses.
Clotrimazole has an antifungal effect due to a violation of the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Active in relation to: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).
Salicylic acid provides keratolytic, antimicrobial action, eliminates corneal layers and promotes deeper penetration of GCS.
Garison® it is a combined drug, the effect of which is due to the components that make up its composition.
Gentamicin sulfate is a broad-spectrum antibiotic from the group of aminoglycosides. It has a bactericidal effect. It is effective against coagulase-positive and coagulase-negative staphylococci (including Staphylococcus aureus), Escherichia coli, indole-positive and indole-negative species Proteus, Pseudomonas aeruginosa, different types of group Klebsiella spp., Enterobacter spp., Serratia spp., and types Citrobacter spp., Salmonella spp., Shigella spp., Moraxella spp. (incl. Moraxella lacunata), Neisseria spp., in particular Neisseria gonorrhoeae.
Betamethasone sodium phosphate-GCS, has a local anti-inflammatory effect, suppressing cellular and fibrinous exudation and normalizing increased capillary permeability, which is manifested by a decrease in local hyperemia, edema and effusion.
In allergic or traumatic corneal lesions, GCS suppresses fibroblast proliferation and post-inflammatory neovascularization of the cornea, thus preserving its transparency.
Betamethasone Dipropionate, Gentamicin Sulfate
Externally. Apply a thin layer to the affected areas of the skin, without rubbing, 2 times a day-in the morning and in the evening. In some patients, it is possible to achieve a satisfactory effect with a single application of the drug.
Acriderm®
Acriderm® GHENT
Acriderm® GC
Externally. Apply a thin layer to the affected area of the skin 2 times a day-in the morning and in the evening. Another frequency of use can be determined by the doctor, based on the severity of the disease. In mild cases, the cream is sufficient to apply, as a rule, 1 time a day, with more severe lesions, more frequent use may be necessary.
The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.
If clinical improvement does not occur, it is necessary to clarify the diagnosis.
Acriderm® SK
Externally. Apply a thin layer to the affected area of the skin 2 times a day-in the morning and in the evening. Another frequency of use can be determined by the doctor, based on the severity of the disease. In mild cases, the ointment is sufficient to apply, as a rule, 1 time a day, with more severe lesions, more frequent use may be necessary.
Diseases of the eye
Conjunctival, the dosage should be determined for each patient individually.
Usually 1-2 drops are instilled into the conjunctival sac of the affected eye 3-4 times a day.
In the acute stage, the frequency of application can be increased to 2 drops every hour or every 2 hours. In the future, when the course of the disease becomes controlled, the frequency of use decreases. The total duration of treatment depends on the nature and severity of the disease. If there is no therapeutic effect within 14 days after the start of treatment, further use of the drug is impractical.
Diseases of the ear
Into the external auditory canal, before using the drug, the external auditory canal should be free.
The recommended initial dose is 3-4 drops 2-4 times a day. The patient should lie on his side so that the affected ear is turned up, after instilling the solution, you should remain in this position for a few more minutes to ensure the penetration of the drug into the ear canal.
With a decrease in inflammatory phenomena, you should gradually reduce the dosage and stop using the drug after the symptoms of the disease disappear.
If necessary, a cotton swab soaked in Garazon can be inserted inside the external auditory canal®. The tampon must be kept moist by wetting it with the drug every 4 hours. The tampon should be replaced every 24 hours.
In chronic diseases, discontinuation of treatment should be made gradually, by reducing the frequency of use of the drug.
