Symptoms: with prolonged use of the drug (more than 7 days) in large doses — nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: induce vomiting, do gastric lavage, take saline laxatives, activated charcoal. In the conditions of a medical institution — forced diuresis, hemodialysis, with the development of a convulsive syndrome-intravenous administration of diazepam and barbiturates.
Hypersensitivity to pyrazolone derivatives in the anamnesis, age (up to 3 months).
The simultaneous use of Analgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the effect of analgin.
Analgin enhances the effects of alcoholic beverages.
Radiopaque substances, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.
Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the protein bond, increases their activity.
Simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of analgin.
Increases chlorpromazine hypothermia.
Concomitant use of Adepiron with other non-narcotic analgesics may lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the effect of Adepiron.
Adepiron enhances the effects of alcoholic beverages.
Radiopaque substances, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.
Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the protein bond, increases their activity.
Simultaneous use of Adepiron with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of Adepiron.
Disorders of the gastrointestinal tract (nausea, vomiting, etc.), agranulocytosis, skin rashes, anaphylactic shock.
Pain syndrome of various etiologies:
headache,
migraine pain,
toothache,
neuralgia,
myalgia,
algodismenorrhea,
postoperative pain,
renal and biliary colic (in combination with antispasmodics),
feverish conditions in infectious and inflammatory diseases.
Moderate and severe pain (headache, toothache, dysmenorrhea), fever.
Pain syndrome of various etiologies:
headache,
migraine pain,
toothache,
neuralgia,
myalgia,
algodismenorrhea,
postoperative pain,
renal and biliary colic (in combination with antispasmodics),
feverish conditions in infectious and inflammatory diseases.
Metamizole sodium is a pyrazolone derivative. It has an analgesic, antipyretic and weak anti-inflammatory effect, the mechanism of which is associated with the inhibition of PG synthesis. The pharmacological effect develops in 20-40 minutes after taking the drug and reaches a maximum in 2 hours.
Adepiron
Sodium Metamizole
In / m or in / in — 2-5 ml 2-3 times a day.
