Symptoms: with prolonged use of the drug (more than 7 days) in large doses — nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: induce vomiting, perform gastric lavage, take saline laxatives, activated charcoal. In a medical institution — forced diuresis, hemodialysis, with the development of convulsive syndrome — intravenous administration of diazepam and barbiturates.
hypersensitivity to pyrazolones derivatives (phenylbutazone, tribuson),
bronchial asthma,
diseases accompanied by bronchospasm,
"aspirin asthma»,
suppression of hematopoiesis (agranulocytosis, neutropenia, leukopenia),
severe hepatic or renal impairment,
diseases of the blood,
hereditary hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency,
pregnancy (especially in the first trimester and in the last 6 weeks),
lactation period.
With caution — infancy (up to 3 months).
The simultaneous use of Analgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the effect of analgin.
Analgin enhances the effects of alcoholic beverages.
Radiopaque substances, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.
Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the protein bond, increases their activity.
Simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of developing leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of analgin.
Solution for intravenous and intramuscular administration
Allergic reactions: skin rash, Quincke's edema, rarely-anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), in rare cases — Stevens-Johnson syndrome.
With prolonged use, leukopenia, thrombocytopenia, agranulocytosis may occur.
With a tendency to bronchospasm, it is possible to provoke an attack, reduce blood pressure.
Possible renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red due to the release of a metabolite.
All side (unusual) effects, including those not mentioned above, should be reported to the attending physician and stop taking the drug.
Pain syndrome of various etiologies:
headache,
migraine pain,
toothache,
neuralgia,
myalgia,
algodismenorrhea,
postoperative pain,
renal and biliary colic (in combination with antispasmodics),
feverish conditions in infectious and inflammatory diseases.
Metamizole sodium is a pyrazolone derivative. It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with the inhibition of the synthesis of PG. Pharmacological action develops in 20-40 minutes after taking the drug and reaches a maximum in 2 hours.
Analgin bufus
Sodium Metamizole
Inside, adults — 1 tab. 2-3 times a day after meals. The maximum single dose is 1 g (2 tablets), the daily dose is 3 g (6 tablets). With prolonged (more than a week) use of the drug, it is necessary to monitor the picture of peripheral blood and the functional state of the liver.
Children are prescribed 5-10 mg/kg of body weight 3-4 times a day for no more than 3 days (after grinding the tablet).
Do not use (without consulting a doctor) for more than 3 days when prescribed as an antipyretic and more than 5 days when prescribed as an analgesic.
N02BB02 Metamizole sodium
