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What is the most important information I should know about Zylocef (ALDE MEDI IMPEX)?
Hypersensitivity: Hypersensitivity to Zylocef (ALDE MEDI IMPEX), any of excipients of Zylocef (ALDE MEDI IMPEX) or to any other cephalosporin. Patients with previous hypersensitivity reactions to penicillin and other β-lactam agents may be at greater risk of hypersensitivity to Zylocef (ALDE MEDI IMPEX).
Lidocaine: It must be excluded before IM injection of Zylocef (ALDE MEDI IMPEX) when lidocaine solution is used as a solvent. Zylocef (ALDE MEDI IMPEX) solutions containing lidocaine should never be administered IV.
Premature Neonates: Zylocef (ALDE MEDI IMPEX) is contraindicated in premature neonates up to postmenstrual age of 41 weeks (gestational age + chronological age).
Hyperbilirubinemic Newborns: Should not be treated with Zylocef (ALDE MEDI IMPEX). In vitro studies have shown that Zylocef (ALDE MEDI IMPEX) can displace bilirubin from its binding to serum albumin, leading to a possible risk of bilirubin encephalopathy in these patients.
Neonates and Calcium-Containing IV Solutions: Zylocef (ALDE MEDI IMPEX) is contraindicated in neonates (≤28 days) if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium-containing infusions eg, parenteral nutrition because of the risk of precipitation of Zylocef (ALDE MEDI IMPEX)-calcium.
A small number of cases of fatal outcomes in which a crystalline material was observed in the lungs and kidneys at autopsy have been reported in neonates receiving Zylocef (ALDE MEDI IMPEX) and calcium-containing fluids. In some of these cases, the same IV infusion line was used for both Zylocef (ALDE MEDI IMPEX) and calcium-containing fluids and in some a precipitate was observed in the IV infusion line. At least 1 fatality has been reported in a neonate in whom Zylocef (ALDE MEDI IMPEX) and calcium-containing fluids were administered at different time points via different intravenous lines; no crystalline material was observed at autopsy in this neonate. There have been no similar reports in patients other than neonates.
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What are the possible side effects of Zylocef (ALDE MEDI IMPEX)?
Post-Marketing: During the use of Zylocef (ALDE MEDI IMPEX), the following side effects, which were reversible either spontaneously or after withdrawal of the drug, have been observed: Systemic Side Effects: Gastrointestinal complaints (about 2% of the cases): loose stools or diarrhea, nausea, vomiting, stomatitis and glossitis.
Hematological changes (about 2%): eosinophilia, leukopenia, granulocytopenia, hemolytic anemia, thrombocytopenia. Isolated cases of agranulocytosis (<500/mm3) have been reported, most of them after 10 days of treatment and following total doses of 20 g or more.
Skin reactions (about 1%): exanthema, allergic dermatitis, pruritus, urticaria, edema. Isolated cases of severe cutaneous adverse reactions (erythema multiforme, Stevens Johnson syndrome or Lyell's Syndrome/toxic epidermal necrolysis) have been reported.
Other, Rare Side Effects: Headache and dizziness, symptomatic precipitation of Zylocef (ALDE MEDI IMPEX) calcium salt in the gallbladder, increase in liver enzymes, oliguria, increase in serum creatinine, genital mycosis, fever, shivering and anaphylactic or anaphylactoid reactions.
Interaction with Calcium: Two in vitro studies, one using adult plasma and the other neonatal plasma from umbilical cord blood have been carried out to assess interaction of Zylocef (ALDE MEDI IMPEX) and calcium. Zylocef (ALDE MEDI IMPEX) concentrations up to 1 mM (in excess of concentrations achieved in vivo following administration of 2 grams Zylocef (ALDE MEDI IMPEX) infused over 30 minutes) were used in combination with calcium concentrations up to 12 mM (48 mg/dL). Recovery of Zylocef (ALDE MEDI IMPEX) from plasma was reduced with calcium concentrations of 6 mM (24 mg/dL) or higher in adult plasma or 4 mM (16 mg/dL) or higher in neonatal plasma. This may be reflective of Zylocef (ALDE MEDI IMPEX)-calcium precipitation.
A small number of cases of fatal outcomes in which a crystalline material was observed in the lungs and kidneys at autopsy have been reported in neonates receiving Zylocef (ALDE MEDI IMPEX) and calcium containing fluids. In some of these cases, the same intravenous infusion line was used for both Zylocef (ALDE MEDI IMPEX) and calcium-containing fluids and in some a precipitate was observed in the intravenous infusion line. At least one fatality has been reported in a neonate in whom Zylocef (ALDE MEDI IMPEX) and calcium-containing fluids were administered at different autopsy in this neonate. There have been no similar reports in patients other than neonates.
Pseudomembranous enterocolitis and coagulation disorders have been reported as very rare side effects.
Very rare cases of renal precipitation have been reported, mostly in children older than 3 years and who have been treated with either high daily doses (e.g. ≥80 mg/kg/day) or total doses exceeding 10 grams and presenting other risk factors (e.g. fluid restrictions, confinement to bed, etc.). This event may be symptomatic or asymptomatic, may lead to renal insufficiency, and is reversible upon discontinuation of Zylocef (ALDE MEDI IMPEX).
Local Side Effects: In rare cases, phlebitis reactions occurred after i.v. administration. These may be minimized by slow (2-4 minutes) injection.
Intramuscular injection without lidocaine solution is painful.Laboratory Abnormalities: Influence on Diagnostic Tests: In patients treated with Zylocef (ALDE MEDI IMPEX) the Coombs' test may rarely become false-positive.
Zylocef (ALDE MEDI IMPEX), like other antibiotics, may result in false-positive tests for galactosemia.
Likewise, nonenzymatic methods for the glucose determination in urine may give false positive results. For this reason, urine-glucose determination during therapy with Zylocef (ALDE MEDI IMPEX) should be done enzymatically.
Before instituting treatment with B Braun Zylocef (ALDE MEDI IMPEX), appropriate specimens should be obtained for isolation of the causative organism and for determination of its susceptibility to the drug. Therapy may be instituted prior to obtaining results of susceptibility testing.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of B Braun Zylocef (ALDE MEDI IMPEX) and other antibacterial drugs, B Braun Zylocef (ALDE MEDI IMPEX) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
B Braun Zylocef (ALDE MEDI IMPEX) is indicated for the treatment of the following infections when caused by susceptible organisms: Lower respiratory tract infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Escherichia. coli, Enterobacter aerogenes, Proteus mirabilis or Serratia marcescens.
Skin and skin structure infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii*, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis* or Peptostreptococcus spp.
Urinary tract infections (complicated and uncomplicated) caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii or Klebsiella pneumoniae.
Pelvic inflammatory disease caused by Neisseria gonorrhoeae. Zylocef (ALDE MEDI IMPEX) sodium, like other cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and Chlamydia trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added.
Bacterial septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae or Klebsiella pneumoniae.
Bone and joint infections caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae or Enterobacter spp.
Intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium spp (Note: Most strains of Clostridium difficile are resistant) or Peptostreptococcus spp.
Meningitis caused by Haemophilus influenzae, Neisseria meningitidis or Streptococcus pneumoniae.
Zylocef (ALDE MEDI IMPEX) sodium has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis* and Escherichia coli*.
*Efficacy for this organism in this organ system was studied in fewer than 10 infections.
Surgical Prophylaxis: The preoperative administration of a single 1 g dose of B Braun Zylocef (ALDE MEDI IMPEX) may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated (eg, vaginal or abdominal hysterectomy or cholecystectomy for chronic calculous cholecystitis in high-risk patients eg, those >70 years of age, with acute cholecystitis not requiring therapeutic antimicrobials, obstructive jaundice or common duct bile stones) and in surgical patients for whom infection at the operative site would present serious risk (eg, during coronary artery bypass surgery). Although Zylocef (ALDE MEDI IMPEX) sodium has been shown to have been as effective as cefazolin in the prevention of infection following coronary artery bypass surgery, no placebo-controlled trials have been conducted to evaluate any cephalosporin antibiotic in the prevention of infection following coronary artery bypass surgery.
When administered prior to surgical procedures for which it is indicated, a single 1 g dose of B Braun Zylocef (ALDE MEDI IMPEX) provides protection from most infections due to susceptible organisms throughout the course of the procedure.
Zylocef (ALDE MEDI IMPEX) is used to treat bacterial infections in many different parts of the body. Zylocef (ALDE MEDI IMPEX) is also given before certain types of surgery to prevent infections.
Zylocef (ALDE MEDI IMPEX) belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Zylocef (ALDE MEDI IMPEX) will not work for colds, flu, or other virus infections.
Zylocef (ALDE MEDI IMPEX) is available only with your doctor's prescription.
B Braun Zylocef (ALDE MEDI IMPEX) is a sterile, nonpyrogenic, single use, packaged combination of Zylocef (ALDE MEDI IMPEX) sodium and dextrose injection (diluent) in the Duplex sterile container. The Duplex container is a flexible dual chamber container.
The drug chamber is filled with Zylocef (ALDE MEDI IMPEX) sodium, a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for IV administration. Zylocef (ALDE MEDI IMPEX) sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.
Its chemical formula is C18H16N8Na2O7S3·3.5H2O. It has a calculated molecular weight of 661.6.
Zylocef (ALDE MEDI IMPEX) sodium is supplied as a dry powder form equivalent to either 1 or 2 g of Zylocef (ALDE MEDI IMPEX). It is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of Zylocef (ALDE MEDI IMPEX) sodium solutions ranges from light yellow to amber, depending on the length of storage and concentration.
Zylocef (ALDE MEDI IMPEX) sodium contains approximately 83 mg (3.6 mEq) of sodium per gram of Zylocef (ALDE MEDI IMPEX) activity.
The diluent chamber contains dextrose injection. The concentration of hydrous dextrose in water for injection USP has been adjusted to render the reconstituted drug product iso-osmotic. Dextrose USP has been added to adjust osmolality (approximately 1.87 g and 1.11 g to 1 g and 2 g dosages, respectively). Dextrose injection is sterile, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents.
The molecular weight of hydrous dextrose USP is 198.17.
After removing the peelable foil strip, activating the seals, and thoroughly mixing, the reconstituted drug product is intended for single IV use. When reconstituted, the approximate osmolality for the reconstituted solution for B Braun Zylocef (ALDE MEDI IMPEX) is 290 mOsmol/kg.
The Duplex container is latex-free, PVC-free, and DEHP-free.
The Duplex dual chamber container is made from a specially formulated material. The product (diluent and drug) contact layer is a mixture of thermoplastic rubber and a polypropylene ethylene copolymer that contains no plasticizers. The safety of the container system is supported by USP biological evaluation procedures.
Use Zylocef (ALDE MEDI IMPEX) exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Zylocef (ALDE MEDI IMPEX) is injected into a muscle, or into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
You may need to mix Zylocef (ALDE MEDI IMPEX) with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Use only the diluent your doctor has recommended.
Do not mix Zylocef (ALDE MEDI IMPEX) in the same injection with other antibiotics, or with any diluent that contains calcium, including a TPN (total parenteral nutrition) solution.
After mixing your medicine, you will need to use it within a certain number of hours or days. This will depend on the diluent and how you store the mixture (at room temperature, in a refrigerator, or frozen). Carefully follow the mixing and storage instructions provided with your medicine. Ask your pharmacist if you have questions.
If you use other injectable medications, be sure to flush your intravenous catheter between injections of each medication.
Use Zylocef (ALDE MEDI IMPEX) for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Zylocef (ALDE MEDI IMPEX) will not treat a viral infection such as the common cold or flu.
Zylocef (ALDE MEDI IMPEX) can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using this medicine.
Store unmixed Zylocef (ALDE MEDI IMPEX) powder at room temperature, away from moisture, heat, and light.
If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsBloodstream infection: Caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, or Klebsiella pneumoniae.
Bone and joint infections (osteomyelitis and/or discitis, prosthetic joint infection, septic arthritis): Caused by S. aureus, S. pneumoniae, E. coli, Proteus mirabilis, K. pneumoniae, or Enterobacter spp.
Gonococcal infection, uncomplicated (cervical/urethral, rectal, and pharyngeal): Caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of N. gonorrhoeae.
Intra-abdominal infection, community-acquired (mild to moderate infection in low-risk patients): Caused by E. coli, K. pneumoniae, Bacteroides fragilis, Clostridium spp. (Note: Most strains of C. difficile are resistant), or Peptostreptococcus spp.
Lower respiratory tract infections (pneumonia, community-acquired): Caused by S. pneumoniae, S. aureus, H. influenzae, Haemophilus parainfluenzae, K. pneumoniae, E. coli, Enterobacter aerogenes, P. mirabilis, or Serratia marcescens.
Meningitis, bacterial: Caused by H. influenzae, Neisseria meningitidis, or S. pneumoniae. Zylocef (ALDE MEDI IMPEX) has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis and E. coli (efficacy for these 2 organisms in this organ system was studied in fewer than 10 infections).
Otitis media, acute: Caused by S. pneumoniae, H. influenzae (including beta-lactamase-producing strains), or Moraxella catarrhalis (including beta-lactamase-producing strains).
Pelvic inflammatory disease (mild to moderate): Caused by N. gonorrhoeae. Zylocef (ALDE MEDI IMPEX), like other cephalosporins, has no activity against Chlamydia trachomatis; therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added.
Skin and soft tissue infections: Caused by S. aureus, S. epidermidis, Streptococcus pyogenes, viridans group streptococci, E. coli, Enterobacter cloacae, Klebsiella oxytoca, K. pneumoniae, P. mirabilis, Morganella morganii (efficacy for this organism in this organ system was studied in fewer than 10 infections), S. marcescens, Acinetobacter calcoaceticus, B. fragilis (efficacy for this organism in this organ system was studied in fewer than 10 infections), or Peptostreptococcus spp.
Surgical prophylaxis, colorectal: To reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated.
Urinary tract infection, complicated (including pyelonephritis): Caused by E. coli, P. mirabilis, Proteus vulgaris, M. morganii, or K. pneumoniae.
Off Label UsesActinomycosis, severe or extensive
Data from a limited number of patients suggest Zylocef (ALDE MEDI IMPEX) may be beneficial for the treatment of severe or extensive actinomycosis.
Intended for IV administration only.
B Braun Zylocef (ALDE MEDI IMPEX) and calcium-containing solutions, including continuous calcium-containing infusions eg, parenteral nutrition, should not be mixed or co-administered to any patient irrespective of age, even via different infusion lines at different sites.
Treatment of Skin and Skin Structure Infections: Recommended Total Daily Dose: 50-75 mg/kg given once a day (or in equally divided doses twice a day). The total daily dose should not exceed 2 g.
Treatment of Serious Miscellaneous Infections Other than Meningitis: Recommended Total Daily Dose: 50-75 mg/kg, given in divided doses every 12 hrs. The total daily dose should not exceed 2 g.
Treatment of Meningitis: Recommended Initial Therapeutic Dose: 100 mg/kg (not to exceed 4 g). Thereafter, a total daily dose of 100 mg/kg/day (not to exceed 4 g daily) is recommended. The daily dose may be administered once a day (or in equally divided doses every 12 hrs). The usual duration of therapy is 7-14 days.
Adults: Usual Daily Dose: 1-2 g given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4 g.
If Chlamydia trachomatis is a suspected pathogen, appropriate antichlamydial coverage should be added, because Zylocef (ALDE MEDI IMPEX) sodium has no activity against this organism.
For preoperative use (surgical prophylaxis), a single dose of 1 g administered IV ½-2 hrs before surgery is recommended.
Generally, B Braun Zylocef (ALDE MEDI IMPEX) therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration of therapy is 4-14 days; in complicated infections, longer therapy may be required.
When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days.
Children: B Braun Zylocef (ALDE MEDI IMPEX) in the Duplex container is designed to deliver a 1 or 2 g dose of Zylocef (ALDE MEDI IMPEX). To prevent unintentional overdose, B Braun Zylocef (ALDE MEDI IMPEX) should not be used in pediatric patients who require less than the full adult dose of Zylocef (ALDE MEDI IMPEX).
Neonates: Hyperbilirubinemic neonates, especially prematures, should not be treated with B Braun Zylocef (ALDE MEDI IMPEX).
Hepatic and Renal Impairment: No dosage adjustment is necessary for patients with impairment of renal or hepatic function; however, blood levels should be monitored in patients with severe renal impairment (eg, dialysis patients) and in patients with both renal and hepatic dysfunctions.
Administration: Directions for Use: B Braun Zylocef (ALDE MEDI IMPEX) should be administered IV by infusion over a period of 30 min.
Vancomycin, amsacrine, aminoglycosides and fluconazole are physically incompatible with Zylocef (ALDE MEDI IMPEX) in admixtures. When any of these drugs are to be administered concomitantly with Zylocef (ALDE MEDI IMPEX) by intermittent IV infusion, it is recommended that they be given sequentially, with thorough flushing of the IV lines (with one of the compatible fluids) between the administrations.
B Braun Zylocef (ALDE MEDI IMPEX) should not be physically mixed with or piggybacked into solutions containing other antimicrobial drugs due to possible incompatibility.
After the indicated stability time periods, unused portions of solutions should be discarded.
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What other drugs will affect Zylocef (ALDE MEDI IMPEX)?
No impairment of renal function has so far been observed after concurrent administration of large doses of Zylocef (ALDE MEDI IMPEX) and potent diuretics (eg, furosemide). There is no evidence that Zylocef (ALDE MEDI IMPEX) increases renal toxicity of aminoglycosides. No effect similar to that of disulfiram has been demonstrated after ingestion of alcohol subsequent to the administration of Zylocef (ALDE MEDI IMPEX). Zylocef (ALDE MEDI IMPEX) does not contain an N-methylthiotetrazole moiety associated with possible ethanol intolerance and bleeding problems of certain other cephalosporins. The elimination of Zylocef (ALDE MEDI IMPEX) is not altered by probenecid. In an in vitro study, antagonistic effects have been observed with the combination of chloramphenicol and Zylocef (ALDE MEDI IMPEX).
Do not use diluents containing calcium eg, Ringer's or Hartmann's solution, to reconstitute Zylocef (ALDE MEDI IMPEX) vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. Precipitation of Zylocef (ALDE MEDI IMPEX)-calcium can also occur when Zylocef (ALDE MEDI IMPEX) is mixed with calcium-containing solutions in the same IV administration line.
Zylocef (ALDE MEDI IMPEX) must not be administered simultaneously with calcium-containing IV solutions, including continuous calcium-containing infusions eg, parenteral nutrition via a Y-site. However, in patients other than neonates, Zylocef (ALDE MEDI IMPEX) and calcium-containing solutions may be administered sequentially of one another, if the infusion lines are thoroughly flushed between infusions with a compatible fluid. In vitro studies using adult and neonatal plasma from umbilical cord, blood demonstrated that neonates have an increased risk of precipitation of Zylocef (ALDE MEDI IMPEX)-calcium.
Based on literature reports, Zylocef (ALDE MEDI IMPEX) is incompatible with amsacrine, vancomycin, fluconazole and aminoglycosides.
In patients treated with Zylocef (ALDE MEDI IMPEX), the Coombs' test may in rare cases be false-positive. Zylocef (ALDE MEDI IMPEX), like other antibiotics, may result in false-positive tests for galactosemia. Likewise, non-enzymatic methods for glucose determination in urine may yield false-positive results. For this reason, glucose level determination in urine during therapy with Zylocef (ALDE MEDI IMPEX) should be carried out enzymatically.
Zylocef (ALDE MEDI IMPEX) may adversely affect the efficacy of oral hormonal contraceptives.
Consequently, it is advisable to use supplementary (nonhormonal) contraceptive measures during treatment and in the month following treatment.
Incompatibilities: Solutions containing Zylocef (ALDE MEDI IMPEX) should not be mixed with or added to other agents. In particular, diluents containing calcium (eg, Ringer's or Hartmann's solution), should not be used to reconstitute Zylocef (ALDE MEDI IMPEX) vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. Zylocef (ALDE MEDI IMPEX) must not be mixed or administered simultaneously with calcium-containing solutions. Based on literature reports, Zylocef (ALDE MEDI IMPEX) is not compatible with amsacrine, vancomycin, fluconazole and aminoglycosides.
