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Provera (medroxyprogesterone)

Marketed in 40 countries across Europe, the Americas, Asia, and Oceania, Provera is a globally distributed brand of medroxyprogesterone, a synthetic progestogen classified within the gestagenic and sex-hormone modulator category. For travellers and expatriates who already know the medication from one market and find themselves looking for it in another, the brand has a recognisable international presence, although packaging, prescription pathways, and labelling vary considerably between regulators.

Medroxyprogesterone is prescribed across several therapeutic areas, including hormonal management in selected oncology indications, contraceptive use, and certain reproductive-health contexts. The structured indication block further down this page lists the registered uses recognised across the markets where Provera is sold; these can differ meaningfully from one country to the next, since national regulators approve hormone products for distinct subsets of indications.

Markets where Provera carries marketing authorisation include Brazil, Canada, China, Finland, and Indonesia, among others. Because the brand is broadly distributed, an expatriate or traveller searching for it abroad will often find either Provera itself or another medroxyprogesterone-containing product on local pharmacy shelves. A pharmacist in the destination country can confirm whether a locally registered product corresponds to what the patient has been using at home, and whether dispensing rules differ.

Other progestogens and hormonal therapies in the broader sex-hormone modulator class are also available worldwide under various molecules and brand names, but they are not freely interchangeable — hormonal therapy is calibrated to the individual indication and patient. Anyone using Provera, considering it, or looking for a regional equivalent should treat substitution as a clinical decision and bring it to a qualified healthcare provider before making any change.

Shelf life

Syringe: 3 years.

Vial: 18 months

Incompatibilities

Not applicable.

List of excipients

Methylparaben (E218)

Macrogol 3350

Polysorbate 80

Propylparaben (E216)

Sodium chloride

Hydrochloric acid

Sodium hydroxide

Water for injections

Preclinical safety data

No data held.

Date of revision of the text

06/2018

Marketing authorisation holder

Pfizer Limited

Ramsgate Road

Sandwich

CT13 9NJ

UK

Special precautions for storage

Do not store above 25°C.

Do not freeze.

Nature and contents of container

1 ml disposable syringe with plunger stopper and tip cap. 1 ml vial with stopper and tip cap.

Marketing authorisation number(s)

PL 00057/0965

Special precautions for disposal and other handling

No special requirements for disposal.

Date of first authorisation/renewal of the authorisation

Date of first authorisation: 27 August 1991

Date of latest renewal: 6 February 1997

Frequently asked questions

What conditions does Provera treat?

Provera is prescribed across several therapeutic areas linked to its progestogenic activity, including hormonal management in selected oncology contexts, contraceptive use, and other reproductive-health indications. As a sex-hormone modulator, its registered uses depend on the country in which it is approved. The structured indication section below this introduction lists each registered use recognised in the markets where Provera is sold.

What is the active ingredient in Provera?

Provera contains medroxyprogesterone, a synthetic progestogen classified within the gestagenic and sex-hormone modulator category, with antitumour and endocrine-therapy applications depending on the indication. Medroxyprogesterone is the same molecule whether sold under the Provera brand or as a generic — internationally, the same active ingredient circulates under several commercial names in markets where multiple manufacturers produce it in parallel.

In how many countries is Provera available?

Provera is registered in 40 countries spanning Europe, the Americas, Asia, and Oceania. Examples include Brazil, Canada, China, Finland, Australia, Egypt, and Indonesia. If your country is not represented in the list shown on this page, a local pharmacist can usually confirm whether medroxyprogesterone is available in that market under a different brand name or as a generic equivalent.

Are there other medications with the same active ingredient as Provera?

Medroxyprogesterone is sold under several brand names worldwide, particularly in markets where the original patent has long expired and generic manufacturers produce it in parallel. Other progestogens and hormonal therapies within the broader sex-hormone modulator class also exist, although they are not interchangeable without medical guidance. To identify a local medroxyprogesterone-containing product, search the active ingredient on Pill2Trip or ask a pharmacist.

Should I consult a doctor before taking Provera?

Yes. Provera is a prescription medication, and hormonal therapy in particular is calibrated to the specific indication, the patient's medical history, and concurrent medications. Prescription requirements, branded packaging, and even available generics differ across regulatory regimes, which matters for travellers and people relocating between countries. Any decision to start, stop, switch, or substitute medroxyprogesterone should be led by a qualified healthcare provider familiar with the patient.