Symptoms: drowsiness, nausea, vomiting, diarrhea, dizziness, and decreased blood pressure.
Treatment: gastric lavage, administration of activated charcoal, maintenance of vital functions of the body. There is no special antidote.
hypersensitivity to the components of the drug,
pregnancy (first trimester),
lactation period,
children up to 2 months (for drops) and up to 3 years (for syrup).
With caution: pregnancy (II and III trimesters).
No drug interactions for butamirate have been described.
When using Deconil препарата® rarely (≥1/10000, <1/1000) the following side effects are observed.
From the central nervous system: drowsiness, dizziness.
From the gastrointestinal tract: nausea, diarrhea.
From the skin: exanthema.
Other: rarely-it is possible to develop allergic reactions.
Symptomatic treatment of dry cough of various etiologies: cough in the preoperative and postoperative period, during surgical interventions, bronchoscopy, whooping cough.
Butamirate, the active substance of Deconil препарата®, is a central-acting antitussive agent. It does not belong to the opium alkaloids either in terms of chemical structure or pharmacological properties.
Suppresses cough, having a direct effect on the cough center. It has a bronchodilating effect (dilates the bronchi). It helps to facilitate breathing, improving spirometry (reduces the resistance of the respiratory tract) and blood oxygenation (saturates the blood with oxygen).
Butamirate is rapidly and completely absorbed when taken orally. After taking 150 mg of butamirate Cmax in the plasma of the main metabolite (2-phenylbutyric acid) is 6.4 mcg/ml and is reached after about 1.5 hours. With repeated administration of the drug, its concentration in the blood remains linear, and no accumulation is observed.
Hydrolysis of butamirate, initially to 2-phenylbutyric acid and diethylaminoethoxyethanol, begins in the blood. These metabolites also have antitussive activity. Like butamirate, the metabolites have an almost maximum (about 95%) degree of binding to plasma proteins, which causes, among other things, their long half-life from plasma. The metabolites are mainly excreted by the kidneys, with acidic metabolites largely associated with glucuronic acid. T1/2 it is 6 hours.
Deconil
Butamirate
Inside, before eating.
Drops: children from 2 months to 1 year — 10 drops 4 times a day, 1-3 years — 15 drops 4 times a day, older than 3 years-25 drops 4 times a day.
Syrup (measured with a measuring cap): children from 3 to 6 years — 5 ml 3 times a day, 6-12 years-10 ml 3 times a day, 12 years and older-15 ml 3 times a day, adults-15 ml 4 times a day.
The measuring cap should be washed and dried after each use. If the cough persists for more than 7 days, you should consult a doctor.
