Hypersensitivity (including to other ACE inhibitors), ascites, pregnancy, breast-feeding (you should stop breastfeeding).
Soft capsule
Headache, dizziness, malaise, cough, nausea, dyspeptic phenomena, hypotension, anaphylactoid reactions (including angioedema).
Essential arterial hypertension of all types, chronic heart failure (mono-and combination therapy).
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Cilazapril
Inside, 1 time a day, if possible at the same time. The dose is set individually. For essential hypertension-2.5 — 5 mg, if necessary — 10 mg, for chronic heart failure–1.25 mg (1/2 table), then 2.5-5 (maximum) mg/day (depending on the condition, tolerability of the drug), the maximum dose is 5 mg / day. Patients who are on hemodialysis are recommended to take it on days free from the procedure, the dose value depends on the blood pressure level.
Inside, at the same time of day, regardless of the meal, 1 time a day.
Arterial hypertension: the recommended initial dose is 1-1. 25 mg (1/2 table of 2.5 mg) 1 time per day. The dose should be selected individually, depending on the dynamics of blood pressure. Maintenance doses of the drug Inhibits® — from 2.5 to a maximum dose of 5 mg, 1 time per day. If taking a dose of 5 mg once a day does not reduce blood pressure enough, to enhance the hypotensive effect, you can simultaneously prescribe diuretics (except potassium-sparing) at a low dose.
Renovascular hypertension: treatment with Inhibace® It should be started with a dose of 0.5 mg (1/2 table of 1 mg) once a day, since in patients with renovascular hypertension, ACE inhibitors can cause a more pronounced decrease in blood pressure than in patients with arterial hypertension. The maintenance dose is selected individually.
Patients with arterial hypertension receiving diuretics: the recommended starting dose for these patients is 0.5 mg (1/2 table of 1 mg) once a day. To reduce the likelihood of symptomatic arterial hypotension, the diuretic should be discontinued for 2-3 days prior to initiation of treatment with drug Inhibits®. If necessary, its reception can then be resumed.
Elderly patients: in hypertension the initial dose of Inhibace® it is from 0.5 mg (1/2 table of 1 mg) to 1.25 mg (1/2 table of 2.5 mg) once a day. The maintenance dose is selected individually depending on the tolerability of the drug, the patient's response to treatment and his clinical condition.
Chronic heart failure: treatment with Inhibace® you should start with a dose of 0.5 mg (1/2 table. 1 mg) 1 time a day under careful medical supervision. Depending on the tolerability of the drug and the clinical condition, the dose is increased to the lowest maintenance dose of 1 mg/day. Further dose selection within the usual maintenance dose (1-2. 5 mg / day) is made on the basis of the patient's therapeutic response to treatment, his clinical condition and tolerability of the drug. The maximum daily dose is 5 mg.
Elderly patients with chronic heart failure, taking large doses of diuretics, the recommended starting dose of 0.5 mg should be strictly observed.
Kidney failure: patients with renal insufficiency may need to reduce the dose depending on the creatinine clearance.
The recommended dosage regimen is indicated in the table.
Table
| Cl creatinine clearance, ml/min | Initial dose | The highest dose |
| >40 | 1 mg 1 time per day | 5 mg 1 time per day |
| 10–40 | 0.5 mg 1 time per day | 2.5 mg 1 time per day |
| <10 | 0.25-0.5 mg 1 or 2 times a week, depending on the dynamics of blood pressure | |
Cirrhosis of the liver: in that case, if patients with liver cirrhosis will require drug treatment of Inhibace®, it should be started with caution with a dose of 0.5 mg (1/2 table of 1 mg) once a day, since severe hypotension may develop.
Children under 18: the efficacy and safety of the drug, Inhibits® not installed.
