Symptoms of overdose
Carboplatin-Ebewe was administered in Phase I studies at a dosage of up to 1600 mg/m2 i.v. per course. At this dosage, life-threatening haematological side effects with granulocytopenia, thrombocytopenia and anaemia were observed. The granulocyte, thrombocyte and haemoglobin nadir were observed between days 9-25 (median: days 12-17). The granulocytes had reached values of > 500/µl after 8-14 days (median: 11) and the thrombocytes values of > 25.000/µl after 3-8 days (median: 7).
The following non-haematological side effects also occurred: renal function disturbances with a 50% drop in the glomerular filtration rate, neuropathy, ototoxicity, sight loss, hyperbilirubinaemia, mucositis, diarrhoea, nausea and vomiting with headache, alopesia, erythema, and severe infection. In the majority of cases, hearing disturbances were transient and reversible.
Treatment of overdose
There is no known antidote for Carboplatin-Ebewe over dosage. The anticipated complications of over dosage would be related to myelosuppression as well as impairment of hepatic and renal function. Bone marrow transplantation and transfusions (thrombocytes, blood) can be effective measures of managing haematological side effects.
Carboplatin-Ebewe is contraindicated in patients with:
- hypersensitivity to the active substance or to other platinum containing compounds
- breast feeding
- severe myelosuppression
- bleeding tumors
- pre-existing severe renal impairment (with creatinine clearance of ≤ 20 ml per minute)
Carboplatin-Ebewe may interact with aluminium to form a black precipitate. Needles, syringes, catheters or intravenous sets containing aluminium parts that may come into contact with Carboplatin-Ebewe should not be used for preparation or administration of Carboplatin-Ebewe. Precipitation can lead to a reduction of the antineoplastic activity.
Incidences of adverse reactions reported here under are based on cumulative data obtain in a large group of patients with various pretreatment prognostic features.
The following frequencies have been used:
Very common (>1/10)
Common (>1/100, <1/10)
Uncommon (>1/1,000, <1/100)
Rare (>1/10,000, <1/1,000)
Very rare (<1/10,000), not known (cannot be estimated from the available data)
Cardiac disorders
Very rare: Cardiovascular events (cardiac failure, embolism) as well as cerebrovascular events (apoplexy) have been reported in single cases (causal relationship with Carboplatin-Ebewe not established). Single cases of hypertension have been reported.
Blood and lymphatic system disorders
Very common: Myelosuppression is the dose-limiting toxicity of Carboplatin-Ebewe. Myelosuppression may be more severe and prolonged in patients with impaired renal function, extensive prior treatment, poor performance status and age above 65. Myelosuppression is also worsened by therapy combining Carboplatin-Ebewe with other compounds that are myelosuppressive. Myelosuppression is usually reversible and not cumulative when Carboplatin-Ebewe is used as a single agent and at the recommended dosages and frequencies of administration.
At maximum tolerated dosages of Carboplatin-Ebewe administered as a single agent, thrombocytopenia, with nadir platelet counts of less than 50 x 109/l, occurs in about a third of the patients. The nadir usually occurs between days 14 and 21, with recovery within 35 days from the start of therapy.
Leukopenia has also occurred in approximately 20% of patients but its recovery from the day of nadir (day 14-28) may be slower and usually occurs within 42 days from the start of therapy. Neutropenia with granulocyte counts below 1 x 109/l occurs in approximately one fifth of patients. Haemoglobin values below 9.5 mg/100ml have been observed in 48% of patients with normal base-line values. Anaemia occurs frequently and may be cumulative.
Common: Haemorrhagic complications, usually minor, have also been reported.
Uncommon: Infectious complications have occasionally been reported.
Rare: Cases of febrile neutropenia have been reported. Single cases of life-threatening infections and bleeding have occurred.
Respiratory, thoracic and mediastinal disorders
Very rare: Pulmonary fibrosis manifested by tightness of the chest and dyspnoea. This should be considered if a pulmonary hypersensitivity state is excluded (see General disorders below).
Nervous system disorders
Common: The incidence of peripheral neuropathies after treatment with Carboplatin-Ebewe is 6%. In the majority of the patients neurotoxicity is limited to paraesthesia and decreased deep tendon reflexes. The frequency and intensity of this side effect increases in elderly patients and those previously treated with cisplatin. Paraesthesia present before commencing Carboplatin-Ebewe therapy, particularly if related to prior cisplatin treatment, may persist or worsen during treatment with Carboplatin-Ebewe. (See Precautions).
Uncommon: Central nervous symptoms have been reported, however, they seem to be frequently attributed to concomitant antiemetic therapy.
Eye disorders
Rare: Transient visual disturbances, sometimes including transient sight loss, have been reported rarely with platinum therapy. This is usually associated with high dose therapy in renally impaired patients. Optic neuritis has been reported in post marketing surveillance.
Ear and labyrinth disorders
Very common: Subclinical decrease in hearing acuity, consisting of high-frequency (4000-8000 Hz) hearing loss determined by audiogram, has been reported in 15% of the patients treated with Carboplatin-Ebewe.
Common: Clinical ototoxicity. Only 1% of patients present with clinical symptoms, manifested in the majority of cases by tinnitus. In patients who have been previously treated with cisplatin and have developed hearing loss related to such treatment, the hearing impairment may persist or worsen.
At higher than recommended doses in combination with other ototoxic agents, clinically significant hearing loss has been reported to occur in paediatric patients when Carboplatin-Ebewe was administered.
Gastrointestinal disorders
Very common: Nausea without vomiting occurs in about a quarter of patients receiving Carboplatin-Ebewe vomiting has been reported in over half of the patients and about one-third of these suffer severe emesis. Nausea and vomiting are generally delayed until 6 to 12 hours after administration of Carboplatin-Ebewe, usually disappear within 24 hours after treatment and are usually responsive to (and may be prevented by) anti-emetic medication. A quarter of patients experience no nausea or vomiting. Vomiting that could not be controlled by drugs was observed in only 1% of patients. Vomiting seems to occur more frequently in previously treated patients, particularly in patients pre-treated with cisplatin.
Painful gastro-intestinal disorders occurred in 17% of patients.
Common: Diarrhoea (6%), constipation (4%), mucositis.
Rare: Taste alteration. Cases of anorexia have been reported.
Renal and urinary disorders
Very common: Renal toxicity is usually not dose-limiting in patients receiving Carboplatin-Ebewe, nor does it require preventive measures such as high volume fluid hydration or forced diuresis. Nevertheless, increasing uric acid and blood urea nitrogen levels or serum creatinine levels can occur.
Common: Renal function impairment, as defined by a decrease in the creatinine clearance below 60 ml/min, may also be observed. The incidence and severity of nephrotoxicity may increase in patients who have impaired kidney function before Carboplatin-Ebewe treatment. Impairment of renal function is more likely in patients who have previously experienced nephrotoxicity as a result of cisplatin therapy.
It is not clear whether an appropriate hydration programme might overcome such an effect, but dosage reduction or discontinuation of therapy is required in the presence of moderate alteration of renal function (creatinine clearance 41-59 ml/min) or severe renal impairment (creatinine clearance 21-40 ml/min). Carboplatin-Ebewe is contra-indicated in patients with a creatinine clearance at or below 20 ml/min.
Skin and subcutaneous tissue disorders
Common: Alopecia.
Metabolism and nutrition disorders
Very common: Decreases in serum electrolytes (sodium, magnesium, potassium and calcium) have been reported after treatment with Carboplatin-Ebewe but have not been reported to be severe enough to cause the appearance of clinical signs or symptoms.
Rare: Cases of hyponatraemia have been reported.
Neoplasms benign, malignant and unspecified (including cysts and polyps)
Uncommon: Secondary malignancies (including promyelocytic leukaemia which occurred 6 years after monotherapy with Carboplatin-Ebewe and preceeding irradiation) have been reported following administration of Carboplatin-Ebewe as a single agent or in combination therapy (causal relationship not established).
General disorders and administration site conditions
Very common: Hyperuricaemia is observed in about one quarter of patients. Serum levels of uric acid can be decreased by allopurinol. Asthenia.
Common: Malaise, urticaria. flu-like syndrome, erythematous rash, pruritis,
Uncommon: Fever and chills without evidence of infection; injection site reactions such as pain, erythema, swelling, urticaria and necrosis
Rare: Haemolytic uraemic syndrome.
Immune system disorders
Common: Allergic reactions to Carboplatin-Ebewe have been reported in less than 2% of patients, e.g., skin rash, urticaria, erythematous rash, and fever with no apparent cause or pruritus. These reactions are similar to those observed after administration of other platinum containing compounds and should be managed with appropriate supportive therapy.
Rare: Anaphylaxis, anaphylactic shock, angio-oedema and anaphylactoid reactions, including bronchospasm, urticaria, facial odema and facial flushing, dyspnoea, hypotension, dizziness, wheezing, and tachycardia have occurred. These were reactions similar to those seen after cisplatin therapy but in a few cases no cross-reactivity was present.
Hepatobiliary disorders
Very common: Abnormalities of liver function tests (usually mild to moderate) have been reported with Carboplatin-Ebewe in about one-third of the patients with normal baseline values. The alkaline phosphatase level is increased more frequently than SGOT, SGPT or total bilirubin The majority of these abnormalities regress spontaneously during the course of treatment.
Rare: Severe hepatic dysfunction (including acute liver necrosis) has been reported after administration of higher than recommended Carboplatin-Ebewe dosages.
Carboplatin-Ebewe has been shown to be embryotoxic and teratogenic in rats. It is mutagenic in vivo and in vitro and although the carcinogenic potential of Carboplatin-Ebewe has not been studied, compounds with similar mechanisms of action and mutagenicity have been reported to be carcinogenic.
Carboplatin-Ebewe is indicated for the treatment of:
1. advanced ovarian carcinoma of epithelial origin in:
- first line therapy
- second line therapy, after other treatments have failed.
2. small cell carcinoma of the lung.
Pharmacotherapeutic group: Antineoplastic agents, Platinum compounds
ATC code: LO1X A02
Carboplatin-Ebewe is an antineoplastic agent. Its activity has been demonstrated against several murine and human cell lines.
Carboplatin-Ebewe exhibited comparable activity to cisplatin against a wide range of tumours regardless of implant site.
Alkaline elution techniques and DNA binding studies have demonstrated the qualitatively similar modes of action of Carboplatin-Ebewe and cisplatin. Carboplatin-Ebewe, like cisplatin, induces changes in the superhelical conformation of DNA, which is consistent with a “DNA shortening effectâ€.
Paediatric patients: safety and efficacy in children have not been established
Following administration of Carboplatin-Ebewe in man, linear relationships exist between dose and plasma concentrations of total and free ultrafilterable platinum. The area under the plasma concentration versus time curve for total platinum also shows a linear relationship with the dose when creatinine clearance > 60 ml/min.
Repeated dosing during four consecutive days did not produce an accumulation of platinum in plasma. After a 1-hour infusion (20-520 mg/m2), plasma levels of total platinum and free (ultrafilterable) platinum decay biphasically following first order kinetics.For free platinum, the initial phase (t alpha) half life is approximately 90 minutes and the later phase (t beta) half life approximately 6 hours. All free platinum is in the form of Carboplatin-Ebewe in the first 4 hours after administration. Protein binding of Carboplatin-Ebewe reaches 85-89% within 24 hours of administration, although during the first 4 hours, only up to 29% of the dose is protein bound.Carboplatin-Ebewe is excreted primarily in the urine, with recovery of approximately 65% of the administered platinum within 24 hours. Most of the drug is excreted in the first 6 hours. Approximately 32% of a given dose of Carboplatin-Ebewe is excreted unchanged. Total body and renal clearances of free ultrafilterable platinum correlate with the rate of glomerular filtration but not tubular secretion. Patients with poor renal function may require dosage adjustments due to altered pharmacokinetics of Carboplatin-Ebewe.
Carboplatin-Ebewe clearance has been reported to vary by 3- to 4- fold in paediatric patients. As for adult patients, literature data suggest that renal function may contribute to the variation in Carboplatin-Ebewe clearance
Warnings:
Carboplatin-Ebewe should be administered by individuals under the supervision of a qualified physician who is experienced in the use of anti-neoplastic therapy. Diagnostic and treatment facilities should be readily available for management of therapy and possible complications.
Carboplatin-Ebewe myelosuppression is closely related to its renal clearance. Patients with abnormal kidney function or receiving concomitant therapy with other drugs with nephrotoxic potential are likely to experience more severe and prolonged myelotoxicity. Renal function parameters should therefore be carefully assessed before, during and after Carboplatin-Ebewe therapy.
Carboplatin-Ebewe Infusion courses should not be repeated more frequently than monthly under normal circumstances. Thrombocytopenia, leukopenia and anaemia occur after administration of Carboplatin-Ebewe. Frequent monitoring of peripheral blood counts is recommended throughout and following therapy with Carboplatin-Ebewe and at weekly intervals thereafter. This will monitor toxicity and help determine the nadir and recovery of haematological parameters and assist in subsequent dosage adjustments. Lowest levels of platelets are generally seen between days 14 and 21 of initial therapy. A greater reduction is seen in patients who previously received extensive myelosuppressive chemotherapy. Lowest levels of white cells occur generally between days 14 and 28 of initial therapy. If levels fall below 2000 cells/mm3 or platelets less than 100,000 cells/mm3 then postponement of Carboplatin-Ebewe therapy until bone barrow recovery is evident, should be considered. This recovery usually takes 5 to 6 weeks. Transfusions may be necessary and dosage reductions recommended for subsequent treatment.
Carboplatin-Ebewe combination therapy with other myelosuppressive compounds must be planned very carefully with respect to dosages and timing in order to minimise additive effects. Supportive transfusional therapy may be required in patients who suffer severe myelosuppression.
Carboplatin-Ebewe can cause nausea and vomiting. Premedication with anti-emetics has been reported to be useful in reducing the incidence and intensity of these effects.
Renal and hepatic function impairment may be encountered with Carboplatin-Ebewe. Very high doses of Carboplatin-Ebewe (> 5 times single agent recommended dose) have resulted in severe abnormalities in hepatic and/or renal function. It is not clear whether an appropriate hydration programme might overcome effects on renal function. Dose reduction or discontinuation of therapy is required in the presence of moderate to severe alteration in renal or hepatic function test..
The incidence and severity of nephrotoxicity may increase in patients who have impaired kidney function before Carboplatin-Ebewe treatment. Impairment of renal function is also more likely in patients who have previously experienced nephrotoxicity as a result of Cisplatin therapy. Although no clinical evidence on compounding nephrotoxicity has been accumulated, it is recommended not to combine Carboplatin-Ebewe with aminoglycosides or other nephrotoxic compounds.
Infrequent allergic reactions to Carboplatin-Ebewe have been reported, e.g. erythematous rash, fever with no apparent cause or pruritus. Rarely anaphylaxis, angio-oedema and anaphylactoid reactions including bronchospasm, urticaria and facial oedema have occurred. These reactions are similar to those observed after administration of other platinum containing compounds and may occur within minutes. The incidence of allergic reactions may increase with previous exposure to platinum therapy; however, allergic reactions have been observed upon initial exposure to Carboplatin-Ebewe. Patients should be observed carefully for possible allergic reactions and managed with appropriate supportive therapy, including antihistamines, adrenaline and/or glucocorticoids.
Neurological evaluation and an assessment of hearing should be performed on a regular basis, especially in patients receiving high dose Carboplatin-Ebewe. Neurotoxicity, such as parasthesia, decreased deep tendon reflexes, and ototoxicity are more likely seen in patients previously treated with cisplatin, other platinum treatments and other ototoxic agents.
The carcinogenic potential of Carboplatin-Ebewe has not been studied but compounds with similar mechanisms of action and mutagenicity have been reported to be carcinogenic
Safety and effectiveness of Carboplatin-Ebewe administration in children are not proven
Aluminium containing equipment should not be used during preparation and administration of Carboplatin-Ebewe.
Carboplatin-Ebewe has no or negligible influence on the ability to drive and use machines. However Carboplatin-Ebewe may cause nausea and vomiting, indirectly impairing the ability to drive and use machines
Dosage and Administration:
Carboplatin-Ebewe should be used by the intravenous route only. The recommended dosage of Carboplatin-Ebewe in previously untreated adult patients with normal kidney function, i.e. creatinine clearance > 60 ml/min is 400 mg/m2 as a single short term IV dose administered by a 15 to 60 minutes infusion. Alternatively, the Calvert formula shown below may be used to determine dosage:
Dose (mg) = target AUC (mg/ml x min) x [GFR ml/min + 25]
| Dose (mg) = target AUC (mg/ml x min) x [GFR ml/min + 25] | ||
| Target AUC | Planned chemotherapy | Patient treatment status |
| 5-7mg/ml.min | single agent Carboplatin-Ebewe | Previously untreated |
| 4-6 mg/ml.min | single agent Carboplatin-Ebewe | Previously treated |
| 4-6mg/ml.min | Carboplatin-Ebewe plus cyclophosphamide | Previously untreated |
Note: With the Calvert formula, the total dose of Carboplatin-Ebewe is calculated in mg, not mg/m2. Calvert's formula should not be used in patients who have received extensive pretreatment**.
**Patients are considered heavily pretreated if they have received any of the following:
- Mitomycin C
- Nitrosourea
- Combination therapy with doxorubicin/ cyclophosphamide/cisplatin,
- Combination therapy with 5 or more agents,
- Radiotherapy > 4500 rad, focused on a 20 x 20 cm field or on more than one field of therapy.
Therapy with Carboplatin-Ebewe should be discontinued in the case of an unresponsive tumour, progressive disease and/or occurrence of not tolerable side effects.
Therapy should not be repeated until four weeks after the previous Carboplatin-Ebewe course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3.
Reduction of the initial dosage by 20-25% is recommended for those patients who present with risk factors such as prior myelosuppressive treatment and low performance status (ECOG-Zubrod 2-4 or Karnofsky below 80).
Determination of the haematological nadir by weekly blood counts during the initial courses of treatment with Carboplatin-Ebewe is recommended for future dosage adjustment.
Impaired renal function:
Patients with creatinine clearance values of less than 60 ml/min are at greater risk to develop myelosuppression.
The optimal use of Carboplatin-Ebewe in patients presenting with impaired renal function requires adequate dosage adjustments and frequent monitoring of both haematological nadirs and renal function.
In case of a glomerular filtration rate of ≤ 20 ml/min, Carboplatin-Ebewe should not be administered at all.
Combination Therapy:
The optimal use of Carboplatin-Ebewe in combination with other myelosuppressive agents requires dosage adjustments according to the regimen and schedule to be adopted.
Use in children:
As no sufficient experience of Carboplatin-Ebewe use in children is available, no specific dosage recommendations can be given.
Elderly:
Dosage adjustment, initially or subsequently, may be necessary, dependent on the physical condition of the patient.
Dilution and Reconstitution:
This product is for single dose use only.
Contamination
In the event of contact of Carboplatin-Ebewe with eyes or skin, wash affected area with copious amounts of water or normal saline. A bland cream may be used to treat transient stinging of skin. Medical advice should be sought if the eyes are affected.
Disposal
Any unused product or waste material should be disposed of in accordance with local requirement.
Dilution
The product must be diluted prior to infusion, with 5 % dextrose solution or 0.9 % sodium chloride solution, to concentrates as low as 0.5 mg/ml.
Guidelines for the safe handling of anti-neoplastic agents:
1 Carboplatin-Ebewe should be prepared for administration only by professionals who have been trained in the safe use of chemotherapeutic agents
2 This should be performed in a designated area.
3 Adequate protective gloves should be worn.
4 Precautions should be taken to avoid the drug accidentally coming into contact with the eyes. In the event of contact with the eyes, wash with water and/or saline.
5 The cytotoxic preparation should not be handled by pregnant staff.
6 Adequate care and precautions should be taken in the disposal of items (syringes, needles, etc.) used to reconstitute cytotoxic drugs. Excess material and body waste may be disposed of by placing in double sealed polythene bags and incinerating at a temperature of 1,000 °C. Liquid waste may be flushed with copious amounts of water.
7 The work surface should be covered with disposable plastic-backed absorbent paper.
8 Use Luer-Lock fittings on all syringes and sets. Large bore needles are recommended to Minimise pressure and the possible formation of aerosols. The latter may also be reduced by the use of a venting needle.
