There are no data concerning cases of drug overdose in humans.
hypersensitivity,
obstruction of the biliary tract,
renal / hepatic insufficiency,
ulcerative colitis, Crohn's disease,
peptic ulcer of the stomach and duodenum,
hemophilia,
children under 18 years of age.
Morphine weakens the effect of hymecromone.
When taken together with metoclopramide, the effect of both drugs is weakened.
Enhances the effects of indirect anticoagulants.
Allergic reactions, diarrhea, flatulence, abdominal pain, ulceration of the gastrointestinal mucosa, headache.
hyperkinetic dyskinesia of the biliary tract and Oddi sphincter,
non-calculous chronic cholecystitis, cholangitis, cholelithiasis,
condition after surgical interventions on the gallbladder and bile ducts,
decreased appetite, nausea, constipation, vomiting (against the background of hyposecretion of bile).
A choleretic drug. Increases the formation and excretion of bile. It has a selective antispasmodic effect on the bile ducts and the sphincter of Oddi (does not reduce the peristalsis of the gastrointestinal tract and blood pressure). Reduces the stagnation of bile, prevents the crystallization of cholesterol and thus the development of cholelithiasis.
When taken orally, it is easily absorbed from the digestive tract, weakly binds to plasma proteins. Cmax the serum level is reached after 2-3 h. T1/2 it is about 1 h. Hymecromone is excreted by the kidneys (about 93% in the form of glucuronate, 1.4% - sulfonate, 0.3% - in unchanged form).
Cantabiline
Hymecromone
Inside, 30 minutes before meals, adults-200-400 mg 3 times a day. The daily dose is up to 1200 mg. The course of treatment is 2 weeks. If you miss a dose, you should take the drug as soon as possible or, if the time of the next dose is approaching, do not take the missed dose. Do not take a double dose at once.
Precautions for use. See "Contraindications" and " Special instructions», Influence on the ability to drive vehicles, mechanisms.
