Overdose leads to the development of hypercalciuria and hypercalcemia.
Symptoms of hypercalcemia: nausea, vomiting, thirst, polydipsia, polyuria, dehydration, and constipation. Chronic overdose with the development of hypercalcemia can lead to liming of blood vessels and organs. The threshold of calcium intoxication is when taking calcium preparations for several months at a dose exceeding 2000 mg/day.
Treatment: in case of intoxication, you should immediately stop therapy and restore the water-electrolyte balance. In chronic overdose, if signs of hypercalcemia are detected, hydration is performed at the initial stage with 0.9% sodium chloride solution. Loop diuretics, such as furosemide, can be used to increase the excretion of calcium, as well as to avoid the formation of edema in the tissues (for example, in congestive heart failure). At the same time, you should refrain from using thiazide diuretics.
In patients with renal insufficiency, hydration is ineffective, such patients are indicated for dialysis. In the case of persistent hypercalcemia, other factors contributing to its development should be excluded, including hypervitaminosis A or D, primary hyperparathyroidism, malignant tumors, renal failure, stiffness of movements.
hypersensitivity to the components of the drug,
increased concentration of calcium in the blood and urine (hypercalcemia, hypercalciuria),
chronic kidney failure,
nefrourolitiaz, nephrocalcinosis,
phenylketonuria and sucrose/isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption.
Preparation of Calcium Sandoz® Forte is not recommended for use in children under 3 years of age due to the lack of data on efficacy and safety in this category.
Combination of calcium carbonate calcium lactogluconate
The simultaneous administration of vitamin D and its derivatives increases the absorption of calcium. When administered in high doses together with vitamin D and its derivatives, calcium may reduce the effect of verapamil and possibly other BCCs.
With the simultaneous use of effervescent tablets calcium carbonate calcium lactogluconate
Thiazide diuretics reduce the excretion of calcium in the urine, so when they are used simultaneously with effervescent tablets of calcium carbonate, calcium lactogluconate
Systemic corticosteroids reduce the absorption of calcium. With their simultaneous use, it may be necessary to increase the dose of effervescent tablets calcium carbonate calcium lactogluconate
When ingested effervescent tablets calcium carbonate calcium lactogluconate
With simultaneous oral administration of bisphosphonate or sodium fluoride, these drugs should be taken at least 3 hours before taking effervescent tablets of calcium carbonate calcium lactogluconate
The absorption of calcium from the gastrointestinal tract may decrease with the simultaneous intake of certain types of food containing oxalic acid (for example, spinach, rhubarb) or phytic acid (in all cereals) due to the formation of insoluble complexes with calcium ions. Patients should not take effervescent tablets calcium carbonate calcium lactogluconate
Effervescent tablet
Very rare (<1/10000) - hypersensitivity reactions, including rash, itching, urticaria, hypercalcemia. In isolated cases, systemic allergic reactions (anaphylactic reaction, facial edema, angioedema) have been reported. Some medical publications have reported the development of hypercalciuria on the background of taking calcium supplements.
Rarely (>1/10000, <1/1000) - flatulence, constipation, diarrhea, nausea, vomiting, epigastric pain. When taken in high doses (2000 mg/day daily for several months), headache, increased fatigue, thirst, and polyuria may occur.
prevention and treatment of calcium deficiency (including pregnancy, lactation, period of intensive growth in children),
adding calcium to specific therapy for the prevention and treatment of osteoporosis,
allergic reactions (maintenance therapy),
osteomalacia (as a supplement to the main therapy, including vitamin D3).
Calcium is a vital mineral element necessary to maintain the balance of electrolytes in the body and the adequate functioning of numerous regulatory mechanisms. Makes up for the Ca deficit2 in the body, it participates in the phosphate-calcium metabolism, has a vitamin, anti-rickety, anti-inflammatory and anti-allergic effect.
Calcium Sandoz® Forte contains two calcium salts (calcium lactogluconate and calcium carbonate), which in the form of effervescent tablets quickly dissolve in water, turning into the active form of calcium, which is easily absorbed. This dosage form provides an adequate intake of calcium in the body in the form of a delicious drink and is intended for the prevention and treatment of acute and chronic calcium deficiency in the body, as well as for the treatment of various types of metabolic disorders in the bone tissue.
Suction. Approximately 25-50% of the oral dose of calcium is absorbed mainly in the proximal part of the small intestine and enters the metabolic calcium depots.
Distribution and metabolism. 99% of the body's calcium reserves are found in the bones and teeth, 1% is found in the intra - and extracellular fluid. Approximately 50% of the total calcium content in the blood is present in the physiologically active ionized form, approximately 5% forms complexes with citrate, phosphate and other anions. The remaining 45% of serum calcium is bound to proteins, mainly albumin.
Output. About 20% of calcium is excreted through the kidneys and 80% - through the intestines. The level of excretion through the kidneys depends on glomerular filtration and tubular reabsorption. Through the intestine, both unabsorbed calcium and the absorbed part of it, which is excreted with bile and pancreatic secretions, are excreted.
Calcium Sandoz Forte (Calcium carbonate_Calcium lactogluconate)
Calcium Carbonate, Calcium Lactogluconate
Inside, regardless of the meal. Before taking the tablet, dissolve it in a glass of water.
Children from 3 to 9 years — 500 mg/day.
Adults and children from 10 years — 1000 mg/day.
In severe cases or with an increased need for calcium (for example, treatment with bisphosphonates), it is possible to increase the dose to 2000 mg/day.
Prevention and treatment of osteoporosis
Children from 3 to 9 years — 500 mg/day.
Adults and children from 10 years — 1000 mg/day.
Duration of therapy: when used to compensate for calcium deficiency, the average duration of treatment is at least 4-6 weeks.
When used for prevention in the complex therapy of osteoporosis, the duration of treatment is determined individually.
