AV-block II and III degree, sinoatrial block, bradycardia (heart rate is less than 55 beats / min), SSS, hypotension (systolic blood pressure is less than 90 mm Hg, especially in myocardial infarction), chronic heart failure IIB-III stages, acute heart failure, cardiogenic shock, hypersensitivity to Propranolol (Biozolam PLUS).
CNS and peripheral nervous system: fatigue, weakness, dizziness, headache, drowsiness or insomnia, vivid dreams, depression, anxiety, confusion, hallucinations, tremors, nervousness, anxiety.
Sensory organs: a decrease in the secretion of tear fluid (dryness and soreness of the eyes).
Cardiovascular system: sinus bradycardia, AV block (up to the full development of cross-blockade and cardiac arrest), arrhythmia, development (worsening) of chronic heart failure, decreased blood pressure, orthostatic hypotension, manifestation of angiospasm (increased peripheral circulatory disorders, cold lower extremities, Raynaud's syndrome), pain in the chest.
Digestive system: nausea, vomiting, epigastric discomfort, constipation or diarrhea, liver problems (dark urine, yellow skin or sclera, cholestasis), changes in taste, elevated liver enzymes, lactate dehydrogenase.
Respiratory system: nasal congestion, bronchospasm.
Endocrine: changes in blood glucose (hypo- or hyperglycemia).
hematopoietic system: thrombocytopenia (unusual bleeding and hemorrhage), leukopenia.
Dermatological reactions: increased sweating, psoriasis such as skin reactions, exacerbation of psoriasis symptoms.
Allergic reactions: itching, skin rash, urticaria.
Other: back pain, arthralgia, reduced potency, withdrawal symptoms (increasing stenocardia attacks, myocardial infarction, increased blood pressure).
Hypertension; stenocardia, unstable stenocardia, sinus tachycardia (including in hyperthyroidism), supraventricular tachycardia, tachysystolic form of atrial fibrillation, supraventricular and ventricular extrasystoles, essential tremor, prevention of migraine, alcohol withdrawal syndrome (agitation, and tremor), anxiety, pheochromocytoma (adjuvant treatment), diffuse toxic goiter and thyrotoxic crisis (as subsidiary means, including intolerance to thyreostatics), sympathadrenalic crises against the backdrop of diencephalic syndrome.
The dosing regimen of Biozolam PLUS is individual. For oral administration the starting dose is 20 mg, the single dose is 40-80 mg, the frequency of reception is 2-3 times / day.
For IV jet slowly injection the initial dose is 1 mg; after 2 minutes is administered the same dose again. In the absence of the effect of it is possible repeated injections.
Maximum doses: for oral administration - 320 mg / day; the repeated IV total dose is 10 mg (under the control of blood pressure and ECG).
This medicine strengthens (relatively) the negative effect of verapamil and diltiazem on myocardium, prolongs the action non depolarizing muscle relaxant, inhibits the excretion of lidocaine. NSAIDs, corticosteroids, estrogens, cocaine weaken the anti-hypertensive effect of Biozolam PLUS; nitrates and other antihypertensive drugs increase it. Heparin, antacids decrease the level of this drug in plasma; cimetidine and phenothiazines increase it. It is not recommended for concomitant use with MAO inhibitors. Slows down the metabolism of theophylline and increase its concentration in blood plasma.
