Recorded active ingredients: Diltiazem
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These listings match the full ingredient set recorded for Altizem-sr. Strength, dosage form and route may differ or be missing. This does not establish interchangeability; confirm a suitable product with a pharmacist.
Not applicable.
Chronic toxicity studies in rats revealed no remarkable changes at oral doses up to 125 mg/kg/day although there was 60% mortality at this dose. In dogs chronically treated with oral doses of 20 mg/kg/day, transient rises in SGPT were observed. Embryotoxicity has been reported in mice, rats and rabbits following i.p. administration of diltiazem. Main types of malformations included limb and tail defects with a small number of vertebral and rib deformities also noted.
There are no additional data of relevance to the prescriber.
Not applicable.
No special requirements.