Symptoms: in case of moderate overdose — nausea, vomiting, tinnitus, hearing impairment, headache, dizziness and confusion. These symptoms disappear when the dose of the drug is reduced.
Severe overdose: fever, hyperventilation, ketosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.
Treatment: symptomatic therapy, hospitalization, lavage, use of activated charcoal, monitoring of acid-base balance, alkaline diuresis, in order to obtain a urine pH between 7.5-8 (forced alkaline diuresis is considered achieved if the concentration of salicylate in the blood plasma is more than 500 mg/l — (3.6 mmol/l, in adults or 300 mg/l-2.2 mmol/l, in children), hemodialysis, compensation for fluid loss.
hypersensitivity to acetylsalicylic acid and other NSAIDs or other components of the drug,
erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase),
hemorrhagic diathesis,
combined use of methotrexate at a dose of 15 mg per week or more,
asthma caused by taking salicylates or other NSAIDs,
pregnancy (I and III trimester),
breastfeeding period,
children under 15 years of age with acute respiratory infections caused by viral infections, due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver dystrophy with acute development of liver failure).
With caution:
concomitant therapy with anticoagulants,
gout,
gastric and/or duodenal ulcer (history), including chronic or recurrent peptic ulcer disease, or episodes of gastrointestinal bleeding,
renal and / or hepatic insufficiency,
glucose-6-phosphate dehydrogenase deficiency.
Joint application:
- with methotrexate at a dose of 15 mg per week or more: the hemolytic cytotoxicity of methotrexate increases (the renal clearance of methotrexate decreases and methotrexate is replaced by salicylates due to plasma proteins),
- with anticoagulants, such as heparin: increased risk of bleeding due to inhibition of platelet function, damage to the gastrointestinal mucosa, displacement of anticoagulants (oral) from the connection with plasma proteins,
with other NSAIDs, as well as with large doses of salicylates (3 g per day or more): as a result of the synergistic interaction, the risk of ulcers and bleeding increases,
- with uricosurates, such as benzbromarone: reduces the uricosuric effect,
- with digoxin: the concentration of digoxin increases due to a decrease in renal excretion,
- with antidiabetic drugs, such as insulin: the hypoglycemic effect of antidiabetic drugs increases due to the hypoglycemic effect of acetylsalicylic acid,
- with drugs of the thrombolytic group: the risk of bleeding increases,
- with diuretics at a dose of 3 mg per day or more: glomerular filtration is reduced due to a decrease in the synthesis of PG,
- with systemic corticosteroids, excluding hydrocortisone, used as a replacement therapy for Addison's disease: when using GCS, the level of salicylates in the blood decreases due to increased excretion of the latter,
- with ACE inhibitors: at a dose of 3 g per day or more, glomerular filtration is reduced due to the inhibition of PG and, as a result, the antihypertensive effect is reduced,
- with valproic acid: increases the toxicity of valproic acid,
- with ethanol: the risk of damaging the gastrointestinal mucosa increases and the bleeding time increases.
Round, flat tablets of white color, on one side the engraving "ALKA SELTZER", in a convex circle protruding around the perimeter, on the other — a chamfer.
Sometimes possible:
From the gastrointestinal tract: abdominal pain, heartburn, nausea, vomiting, obvious (vomiting with blood, tar-like stools) or hidden signs of gastrointestinal bleeding that can lead to iron deficiency anemia, erosive and ulcerative lesions (including perforation) of the gastrointestinal tract, isolated cases-liver function disorders (increased liver transaminases).
From the hematopoietic system: increased risk of bleeding, which is a consequence of the effect of acetylsalicylic acid on platelet aggregation.
Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, Quincke's edema.
If such symptoms occur, it is recommended to stop taking the drug and immediately consult your doctor.
Acetylsalicylic acid may cause bronchospasm, asthma attack, or other hypersensitivity reactions.
Risk factors include the presence of bronchial asthma, nasal polyps, fever, chronic bronchopulmonary diseases, and a history of allergies (allergic rhinitis, skin rashes).
Acetylsalicylic acid may increase the tendency to bleed, due to its inhibitory effect on platelet aggregation. This should be taken into account when surgical procedures are necessary, including minor interventions such as tooth extraction. Before surgery, to reduce bleeding during the operation and in the postoperative period, you should stop taking the drug for 5-7 days and inform the doctor.
If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Children should not be prescribed drugs containing acetylsalicylic acid, since in the case of a viral infection, the risk of Reye's syndrome increases. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.
In the treatment of vascular diseases, the daily dose of acetylsalicylic acid is from 75 to 300 mg.
Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.
One effervescent tablet of Alka-Seltzer contains 445 mg of sodium, which should be taken into account when dieting with controlled sodium intake.
The effect of taking the drug on driving a motor vehicle and other mechanisms was not revealed.
symptomatic treatment of pain syndrome — headache (including after excessive alcohol consumption), toothache, sore throat, back and muscle pain, joint pain, menstrual pain,
increased body temperature in colds and other infectious and inflammatory diseases (in adults and children over 15 years old).
A combined drug, the effect of which is due to its constituent components.
Acetylsalicylic acid It has analgesic, antipyretic, anti-inflammatory effect, which is due to the inhibition of COX enzymes involved in the synthesis of PG. Acetylsalicylic acid inhibits platelet aggregation, blocking the synthesis of thromboxane A2.
Sodium Carbonate neutralizes free hydrochloric acid in the stomach, which reduces the irritating effect of the drug.
Citric acid promotes faster absorption of the drug.
At a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life of Alka-Seltzer3 года.Do not use after the expiration date indicated on the package.
| Effervescent tablets | 1 table. |
| acetylsalicylic acid | 324 mg |
| citric acid, anhydrous | 965 mg |
| monosubstituted sodium carbonate | 1625 mg |
| excipients: povidone 25, siloxane / silicate, doss-sodium benzoate, sodium saccharinate, flavors-lemon and lime |
in a strip of 2 pieces, in a pack of cardboard 5 strips or in a strip of 10 pieces, in a pack of cardboard 1 or 2 strips.
Contraindicated in the first and third trimesters of pregnancy.
If it is necessary to use the drug during lactation, breastfeeding should be discontinued.
Inside, pre-dissolved in a glass of water.
Adults and children over 15 years of age — 1 table. up to 6 times a day. For severe pain and high fever — 2-3 tablets, the maximum daily dose should not exceed 9 tablets (3 g).
The interval between doses of the drug should be at least 4 hours. Regular compliance with the regimen of taking the drug allows you to avoid a sharp increase in temperature and reduce the intensity of the pain syndrome.
The duration of treatment (without consulting a doctor) should not exceed 5 days when prescribed as an analgesic and more than 3 days - as an antipyretic.
N02BA51 Acetylsalicylic acid in combination with other drugs other than psycholeptics
