There was no data on overdose with the drug A-Calm®.
Treatment: рекомендуется промывание желудка, симптоматическая терапия. Специфического антидота нет.
hypersensitivity to any of the components of the drug
myasthenia gravis
children under 3 years of age.
Data on interactions that limit the use of the drug A-Calm® is not available.
Although tolperizone has an effect on the central nervous system, it does not cause a sedative effect, so it can be used in combination with sedatives, hypnotics and drugs containing alcohol.
It does not affect the effect of alcohol on the central nervous system.
Tolperizone increases the effect of niflumic acid, with the simultaneous use of these drugs, it may be necessary to reduce the dose of niflumic acid.
Funds for General anesthesia, peripheral muscle relaxants, psychotropic drugs, clonidine — enhance the effect tolperisone.
Muscle weakness, headache, hypotension, nausea, vomiting, abdominal discomfort. When the dose is reduced, side effects usually disappear. In rare cases, there are allergic reactions (skin itching, erythema, urticaria, angioedema, anaphylactic shock, bronchospasm).
treatment of pathologically increased muscle tone and spasms of striated muscles resulting from organic diseases of the central nervous system (damage to the pyramidal pathways, multiple sclerosis, brain stroke, myelopathy, encephalomyelitis)
treatment of increased tone and muscle spasms, muscle contractures accompanying diseases of the organs of movement (including spondylosis, spondyloarthrosis, cervical and lumbar syndromes, arthrosis of large joints)
rehabilitation treatment after orthopedic and traumatological operations
as part of the combination therapy of obliterating vascular diseases (obliterating atherosclerosis, diabetic angiopathy, obliterating thrombangiitis, Raynaud's disease, diffuse scleroderma), diseases arising from vascular innervation disorders (acrocyanosis, intermittent angioedema)
Little's disease (infantile brain paralysis) and other encephalopathies accompanied by muscular dystonia.
Central-acting muscle relaxant. The mechanism of action is not fully understood. It has a membrane-stabilizing, local anesthetic effect, inhibits the conduction of impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono - and polysynaptic reflexes. It also probably inhibits the release of mediators by inhibiting the intake of Ca for a second time.2 to the synapses. In the brain stem, it eliminates the facilitation of arousal along the reticulospinal pathway. Increases peripheral blood flow regardless of the influence of the central nervous system. In the development of this effect plays the role of a weak spasmolytic and adrenoblokatorami effect tolperisone.
After oral administration, tolperizone is well absorbed from the gastrointestinal tract. Cmax is reached after 0.5-1 h, bioavailability is about 20%.
Tolperison metabolized in the liver and kidneys. It is excreted in the urine in the form of metabolites (more than 99%). The pharmacological activity of the metabolites is unknown.
A-Calm
Tolperisone
Inside, после еды, не разжевывая, запивая небольшим количеством воды.
Adults and children from 14 years old — обычно начиная с 50 мг 2–3 раза в день, постепенно повышая дозу до 150 мг 2–3 раза в день.
Children from 3 to 6 years old — A-Calm® назначают внутрь в суточной дозе 5 мг/кг; 7-14 years old — 2–4 мг/кг (в 3 приема в течение дня).
