Symptoms of overdose are not described.
Hypersensitivity.
No clinically significant effects of interaction with other drugs have been described.
Dyspeptic phenomena, headache (in rare cases requiring a break in treatment).
varicose veins of the lower extremities
chronic lymphovenous insufficiency of the lower extremities
exacerbation of hemorrhoids
microcirculation disorders.
Chronic venous insufficiency of the lower extremities, manifested by a feeling of heaviness in the legs, pain and trophic disorders
Diosmin has a venotonizing effect (reduces the extensibility of veins, increases the tone of veins (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of white blood cells to the venous wall and their migration to the paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, has an anti-inflammatory effect. Increases the vasoconstrictive effect of epinephrine, norepinephrine, serotonin, blocks the production of free radicals, the synthesis of PG and thromboxane
It is quickly absorbed from the gastrointestinal tract. It is detected in the plasma starting from the second hour after administration, Cmax in plasma is reached in 5 hours. It is distributed and accumulates in the walls of the hollow veins and subcutaneous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs, in other tissues it is determined in a small amount. Selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after administration and persists for the next 96 hours. It is excreted in the urine — 79%, with feces-11% and with bile-2.4%.
Rompun
Diosmin
Inside, when venous insufficiency — 600 mg/day (in the morning before meals), in the treatment of hemorrhoids-1200-1800 mg/day (during meals).
