No information provided.
Renal diseases, and patients sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.
Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, irritability, and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug.1,2 Also dizziness, headache, skin flushing reported when used orally.1,3
Yocon (yohimbine hydrochloride) is indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac.
Yocon ® (Yohimbine Hydrochloride, USP) Tablets 1/12 gr 5.4 mg Bottles of 100 - NDC 0516-0001-01 Bottles of 1,000 - NDC 0516-0001-10
1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.
3. Weekly Urological Clinical letter, 27:2, July 4, 1983
4. A. Morales et al., The Journal of Urology 128: 45-47, 1982.
Glenwood, LLC., 111 Cedar Lane, Englewood, NJ 07631. 1-800-542-0772. Page Last Updated: Tuesday, April 1st: 2008. FDA rev date: n/a
Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor, should it be used in conjunction with mood-modifying drugs such as antidepressants, or in psychiatric patients in general.
PRECAUTIONSNo information provided.
Experimental dosage reported in treatment of erectile impotence:1, 3, 4 1 tablet (5.4 mg) 3 times a day, to adult males taken orally. Occasional side effects reported with this dosage are nausea, dizziness or nervousness. In the event of side effects dosage is to be reduced to ½ tablet 3 times a day, followed by gradual increases to 1 tablet 3 times a day. Reported therapy not more than 10 weeks.3
Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral alpha-adrenergic blockade. These include, anti-diuresis, a general picture of central excitation including elevation of blood pressure and heart rate, increased motor activity, irritability, and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug.1,2 Also dizziness, headache, skin flushing reported when used orally.1,3
DRUG INTERACTIONSNo information provided.
1. A. Morales et al., New England Journal of Medicine: 1221. November 12, 1981.
2. Goodman, Gilman - The Pharmacological basis of Therapeutics 6th ed., p. 176- 188, McMillan
3. Weekly Urological Clinical letter, 27:2, July 4, 1983
