Marketed in 46 countries across Europe, the Americas, and parts of Asia, Vigamox is a globally distributed brand of moxifloxacin, classified within the bactericidal and ophthalmological categories. The breadth of its registration means travellers and expatriates regularly encounter the brand in pharmacies far from where it was first prescribed, which is the situation this page is written for.
The active ingredient, moxifloxacin, is used in the management of bacterial infections, with indications that span ophthalmic infections such as bacterial conjunctivitis as well as certain respiratory and other systemic bacterial infections. The structured indication block further down this page lists each registered use as recognised by national regulators in the markets where Vigamox is sold.
Because Vigamox carries marketing authorisation across a wide regulatory spread — including Germany, Canada, Chile, Finland, and Hong Kong among others — the same active ingredient is sometimes encountered under the Vigamox brand and sometimes as a moxifloxacin-containing product sold under another name. Packaging, prescription pathways, and even the form in which moxifloxacin is supplied can differ noticeably from one country to another, and a local pharmacist is generally the most efficient point of contact for confirming whether a moxifloxacin product on a regional shelf corresponds to what was originally prescribed.
Other antibacterial agents within the broader bactericidal class also circulate internationally under their own molecules and brand names, but they are not interchangeable with moxifloxacin without medical input — antibacterial choice depends on the specific infection, local resistance patterns, and patient history. Anyone already taking Vigamox, considering it, or trying to identify a regional equivalent should treat the question as a clinical one and bring it to a healthcare provider rather than resolving it at the counter.
Overdose
No information provided.
Undesirable effects
Because clinical trials are conducted under widely
varying conditions, adverse reaction rates observed in the clinical trials of a
drug cannot be directly compared to the rates in the clinical trials of another
drug and may not reflect the rates observed in practice.
The most frequently reported ocular adverse events were
conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort,
ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, and
tearing. These events occurred in approximately 1-6% of patients.
Nonocular adverse events reported at a rate of 1-4% were
fever, increased cough, infection, otitis media, pharyngitis, rash, and
rhinitis.
Pharmacokinetic properties
Plasma concentrations of moxifloxacin were measured in
healthy adult male and female subjects who received bilateral topical ocular
doses of VIGAMOX® solution 3 times a day. The mean steady-state Cmax (2.7
ng/mL) and estimated daily exposure AUC (45 ng•hr/mL) values were 1,600 and
1,000 times lower than the mean Cmax and AUC reported after therapeutic 400 mg
doses of moxifloxacin. The plasma half-life of moxifloxacin was estimated to be
13 hours.
Date of revision of the text
Apr 2015
Fertility, pregnancy and lactation
Pregnancy Category C.
Teratogenic Effects
Moxifloxacin was not teratogenic when administered to
pregnant rats during organogenesis at oral doses as high as 500 mg/kg/day
(approximately 21,700 times the highest recommended total daily human
ophthalmic dose); however, decreased fetal body weights and slightly delayed
fetal skeletal development were observed. There was no evidence of
teratogenicity when pregnant Cynomolgus monkeys were given oral doses as high
as 100 mg/kg/day (approximately 4,300 times the highest recommended total daily
human ophthalmic dose). An increased incidence of smaller fetuses was observed
at 100 mg/kg/day.
Since there are no adequate and well-controlled studies
in pregnant women, VIGAMOX® solution should be used during pregnancy only if
the potential benefit justifies the potential risk to the fetus.