Acute overdose of local use of Vagil is unlikely and does not lead to a life-threatening situation.
With simultaneous use with amphotericin B, nistatin, the activity of clotrimazole may decrease.
Efficiency reduces nystatin.
The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted - redness of the oral mucosa, a feeling of burning and tingling at the place of application of the drug, urticaria.
If irritation occurs, the drug must be undone.
Allergic reactions: hyperemia, itching, rash.
Clotrimazole is a derivative of imidazole, an antifungal agent of a wide range of actions.
The antimicrotic effect is associated with a violation of the synthesis of ergosterin, which is part of the cell membrane of mushrooms, which causes a change in its structure and properties and leads to a cell lysis.
Dermatophytes, yeast-like mushrooms (birth) are sensitive to clotrimazole Candida, Torulopsis glabrata, Rhodotorula), mold mushrooms, as well as the causative causative of multi-colored lichen Pityriasis versicolor and the causative agent of erythrazma.
It has an antimicrobial effect in relation to gram-positive (staphylocococci and streptococcus) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis)as well as in relation Trichomonas vaginalis.
It has a wide range of activities. Active in relation to dermatophytes, yeast mushrooms of the genus Candida; Corynebacterium minutissimum, Staphylococcus spp., Streptococcus spp.trichomonad.
When used locally, adsorption of clotrimazole from mucous membranes is negligible.
It is characterized by high penetration. The concentration in the epidermis is higher than in the dermis and subcutaneous tissue. Almost does not have a systemic effect.
