Symptoms:with prolonged use of the drug (more than 7 days) in large doses, nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood PRESSURE, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: induce vomiting, do gastric lavage, take saline laxatives, activated charcoal. In the conditions of a medical institution — carrying out forced diuresis, hemodialysis, with the development of convulsive syndrome & nbsp; & mdash; intravenous administration of diazepam and barbiturates.
history of Hypersensitivity to pyrazolone derivatives, age (up to 3 months).
Concomitant use of Analgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives and allopurinol disrupt the metabolism of Metamizole in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the effect of analgin.
Analgin enhances the effects of alcoholic beverages.
X-ray contrast agents, colloidal blood substitutes and penicillin should not be used during treatment with Metamizole.
Metamizole, displacing connection with protein oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indometacin, increases their activity.
Simultaneous use Of analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of analgin.
Increases chlorpromazine hypothermia.
Concomitant use of Novaminsulfone with other non-narcotic analgesics may lead to a mutual increase in toxic effects.
Tricyclic antidepressants, oral contraceptives and allopurinol disrupt the metabolism of Metamizole in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the effect of Novaminsulfon.
Novaminsulfon enhances the effects of alcoholic beverages.
Radiopaque substances, colloidal blood substitutes and penicillin should not be used during treatment with Metamizole.
Metamizole, displacing connection with protein oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indometacin, increases their activity.
Concomitant use of Novaminsulfone with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of Novaminsulfon.
Pain syndrome of various etiologies:
headache;
migraine pain
toothache.
neuralgia
myalgia;
algomenorrhea;
postoperative pain
renal and biliary colic (in combination with spasmolytic drugs);
fever in infectious and inflammatory diseases.
Moderate and severe pain (headache, toothache, dysmenorrhea), fever.
Pain syndrome of various etiologies:
headache;
migraine pain
toothache.
neuralgia
myalgia;
algomenorrhea;
postoperative pain
renal and biliary colic (in combination with spasmolytic drugs);
fever in infectious and inflammatory diseases.
In / m or in/in & nbsp; & mdash; 2 5 & nbsp;ml 2 & nbsp;3 times a day.
