Acute overdose of local use of Gino-Canesten 1 is unlikely and does not lead to a life-threatening situation.
Hypersensitivity to the components of the drug.
With simultaneous use with amphotericin B, nistatin, the activity of clotrimazole may decrease.
The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted - redness of the oral mucosa, a feeling of burning and tingling at the place of application of the drug, urticaria.
If irritation occurs, the drug must be undone.
Gino-Canesten 1ozny stomatitis.
Clotrimazole is a derivative of imidazole, an antifungal agent of a wide range of actions.
The antimicrotic effect is associated with a violation of the synthesis of ergosterin, which is part of the cell membrane of mushrooms, which causes a change in its structure and properties and leads to a cell lysis.
Dermatophytes, yeast-like mushrooms (birth) are sensitive to clotrimazole Candida, Torulopsis glabrata, Rhodotorula), mold mushrooms, as well as the causative causative of multi-colored lichen Pityriasis versicolor and the causative agent of erythrazma.
It has an antimicrobial effect in relation to gram-positive (staphylocococci and streptococcus) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis)as well as in relation Trichomonas vaginalis.
When used locally, adsorption of clotrimazole from mucous membranes is negligible.
Locally, 10–20 drops (1 / 2–1 ml) are applied to affected areas of the oral cavity using a cotton swab 3–4 times a day. Improving the condition usually occurs on the 3–5th day of treatment, but treatment must be continued until the clinical manifestations of the disease are completely eliminated.
