Symptoms:nausea, vomiting, dilated pupils, general weakness, tachycardia, clonic convulsions, respiratory paralysis. They occur when the patient does not comply with the dosage regimen and takes the drug in doses several times higher than the therapeutic ones.
Treatment:gastric lavage, administration of activated charcoal, infusion of water-salt solutions, as well as 5 or 10% glucose solution, administration of anticonvulsants, cardiotonics, respiratory analeptics and other symptomatic agents. It is necessary to monitor the work of the respiratory system, blood pressure and heart rate.
hypersensitivity to the active or any of the excipients of the drug;
acute myocardial infarction;
unstable angina;
cardiac arrhythmia;
recent cerebral circulatory disorder;
atherosclerosis;
severe arterial hypertension;
lactase deficiency, galactosemia, glucose-galactose malabsorption syndrome (the drug contains lactose);
pregnancy;
breastfeeding period;
age before 18 and after 65 years.
With caution:other forms of coronary heart disease (stable angina, asymptomatic (silent) myocardial ischemia, vasospastic angina, syndrome "X" (microvascular angina); heart failure, high blood pressure; diseases of the cerebral vessels; obliterating arterial diseases, hyperthyroidism, gastric ulcer, diabetes mellitus, renal or hepatic insufficiency, some forms of schizophrenia, the presence of chromaffin tumors adrenal glands; gastroesophageal reflux disease; persons with long-term smoking experience and persons older than 40–45 years (see. "Special instructions»). The use of the drug in patients with diseases listed in the section "With caution" is possible only after consulting a doctor.
After stopping smoking, the side effects of theophylline, ropinirole, clozapine and olanzapine may increase.
With simultaneous use of Desmoxan® with acetylcholine, carbachol, galantamine, pyridostigmine, rivastigmine, distigmine, it is possible to increase cholinomimetic side effects (salivation, lacrimation, bronchial secretion with cough and the risk of an asthma attack, pupil constriction, colic, nausea, vomiting, frequent urination, increased muscle tone or sudden muscle contractions).
Use of Desmoxan ® simultaneously with lovastatin, simvastatin, fluvastatin, pravastatin, etc.. increases the risk of muscle pain.
Concomitant use of Desmoxan® with antihypertensive agents (propranolol, etc.) may weaken their effect.
The drug is usually well tolerated, the observed side effects are mild or moderate. Most of them appear at the beginning of treatment and pass on their own. Most often, they are associated with quitting smoking and are manifested by dizziness, headache and insomnia.
At the recommended doses, Desmoxan ® does not cause serious adverse effects.
The following side effects are possible:
From the CCC side: tachycardia, slight increase in blood pressure, palpitation sensation.
From the central nervous system:headache, dizziness, insomnia or drowsiness, increased irritability.
From the respiratory system: shortness of breath.
From the gastrointestinal tract:dry mouth, nausea, abdominal pain, constipation, diarrhea, changes in taste and appetite.
Musculoskeletal and connective tissue disorders: muscle pain.
From the side of metabolism and nutrition: weight loss, increased sweating.
Other: chest pain.
Physical and psychological dependence on nicotine is considered a certain type of disease that leads to the inability to abstain from smoking, even when understanding its negative effects.
With a close similarity to the mechanism of action of nicotine, cytisine has a much lower toxicity and a higher therapeutic index.Cytisine competitively suppresses the interaction of nicotine with the corresponding receptors, which leads to a gradual decrease and disappearance of nicotine dependence.
Inside, whole, washed down with a sufficient amount of liquid. Do not exceed the recommended dose. It is advisable to start taking the drug after the patient is set to completely stop smoking.
The drug should be used according to the following scheme: from the 1st to the 3rd day & mdash; 1 table. 6 times a day (every 2 hours), gradually reducing the number of cigarettes smoked. The pill should be taken between smoking episodes to lengthen the intervals between smoking cigarettes to minimize their consumption. The interval of reception every 2 hours should be observed. If the result is unsatisfactory, the treatment should be stopped and after 2-3 months you can start it again.
With a good effect, treatment is continued according to the following scheme: from the 4th to the 12th day, 1 table. every 2.5 hours; from the 13th to the 16th day & mdash; 1 table. every 3 hours; from the 17th to the 20th day & mdash; 1 table. every 5 hours; from the 21st to the 25th day & nbsp; & mdash; 1 & ndash;2 table. in the day.
It is strongly recommended to stop smoking no later than the 5th day from the start of treatment. Combination of drug therapy with consultations, in t.tsch. with measures of psychological support of the patient, significantly increases the effectiveness of treatment.
