Hypersensitivity, first trimester of pregnancy, breast-feeding.
Pregnancy (first trimester), childhood (up to 3 years).
Preparations containing codeine make it difficult to discharge liquefied sputum. Promotes the penetration of antibiotics, including tetracyclines, erythromycin, cephalexin and sulfonamides into the bronchial mucosa and lung tissue.
Syrup, Tablets for children
Rarely, with prolonged use — nausea, vomiting, dyspeptic phenomena, exacerbation of gastric ulcer and duodenal ulcer, increased levels of transaminases in the blood serum, allergic reactions (skin rash, rhinitis, etc.).
Dyspepsia, increased activity of aminotransferases.
Acute and chronic inflammatory diseases of the lungs, accompanied by the formation of difficult-to-separate viscous sputum (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, emphysema of the lungs, pneumoconiosis), chest injuries.
Chronic inflammatory lung diseases (bronchial asthma, cystic fibrosis, tuberculosis, tracheobronchitis, spastic bronchitis, bronchiectasia, emphysema, pneumoconiosis), chest injuries, pre - and postoperative period.
After oral administration, almost completely (99%) is absorbed within 30 minutes. Bioavailability-80%, binds to plasma proteins, passes through the BBB and placental barrier. It is metabolized in the liver, partially with the formation of active metabolites. T1/2 — 1 h, in the terminal phase-15 h (due to reverse diffusion from the tissues). It is excreted by the kidneys, with repeated use it can accumulate. Against the background of severe hepatic impairment, the clearance decreases, and in chronic renal failure, the excretion of metabolites is disrupted.
Bromhexine Grindex
Bromhexine
Inside (regardless of food intake), adults and children over 14 years — 8-16 mg (2-4 hours).spoons) 3 times a day, for children from 6 to 14 years — 4-8 mg (1-2 hours).spoons) 3 times a day, children from 2 to 6 years — 2-4 mg (1/2–1 hour).spoon) 3 times a day, for children under 2 years - 2 mg (1/2 teaspoon) 3 times a day. The course of treatment is from 4 to 28 days. In the course of treatment, it is recommended to consume a sufficient amount of liquid.
Inside, 1-2 tablets 3-4 times a day, children from 3 to 5 years-0.002 g, from 6 to 14 years-0.004 g 3 times a day. The course lasts from 4 to 28 days.
R05CB02 Bromhexine
