hypersensitivity to the components of the drug,
pregnancy,
children under 12 years of age (due to the presence of alcohol).
impaired motor function of the bronchi and increased volume of secreted secretions (for example, with ciliary dyskinesia syndrome or immobility of the cilia-the risk of stagnation of sputum), bronchial asthma (accidental inhalation of levomentol, eucalyptus and mint oils in the composition of the drug can lead to laryngospasm or can cause an attack of bronchial asthma), reduced kidney function or severe liver disease (should be used with extreme caution. t.e. increasing the intervals between doses of the drug or reducing the dose taken), severe renal failure (possible accumulation of bromhexine metabolites formed in the liver should be taken into account)
Bromhexin 8 promotes the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfonamide drugs into the bronchial secretions in the first 4-5 days of antimicrobial therapy.
The frequency of adverse reactions listed below was determined according to the following criteria: very common (≥10%), common (≥1% to <10%), infrequent (≥0.1% to <1%), rare (≥0.01% to <0.1%), very rare (<0.01%), frequency unknown (cannot be estimated based on available data).
From the gastrointestinal tract:
General well-being: infrequently-fever, allergic reaction (suffocation).
When taken orally, bromhexine is almost completely (99%) absorbed into the gastrointestinal tract within 30 minutes. Bioavailability is 80% due to the effect of the first pass through the liver. Bromhexine in plasma binds to proteins, penetrates through the BBB and the placental barrier. In the liver, bromhexine undergoes demethylation and oxidation, and some of the resulting metabolites (ambroxol) remain active. T1/2 is 15 h due to slow reverse diffusion from the tissues. C
adults and children over 10 years — 10-20 ml 3 times a day, children 6-10 years — 5-10 ml 3 times a day, children 2 to 5 years-2.5-5 ml 3 times a day.
