Hypersensitivity.
Hypersensitivity, first trimester of pregnancy, breast-feeding.
Promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.
Preparations containing codeine make it difficult to discharge liquefied sputum. Promotes the penetration of antibiotics, including tetracyclines, erythromycin, cephalexin and sulfonamides into the bronchial mucosa and lung tissue.
Tablets, Syrup
In rare cases, dyspeptic disorders, allergic reactions.
Rarely, with prolonged use — nausea, vomiting, dyspeptic phenomena, exacerbation of gastric ulcer and duodenal ulcer, increased levels of transaminases in the blood serum, allergic reactions (skin rash, rhinitis, etc.).
Acute and chronic diseases of the bronchi and lungs with impaired sputum discharge.
Acute and chronic inflammatory diseases of the lungs, accompanied by the formation of difficult-to-separate viscous sputum (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, emphysema of the lungs, pneumoconiosis), chest injuries.
Almost completely absorbed. Binding to plasma proteins-99%. The volume of distribution is about 7 l/kg. Penetrates through the BBB and placental barrier, as well as into breast milk. T1/2 — from 1 to 16 hours. It is excreted only in the urine in the form of metabolites.
After oral administration, almost completely (99%) is absorbed within 30 minutes. Bioavailability-80%, binds to plasma proteins, passes through the BBB and placental barrier. It is metabolized in the liver, partially with the formation of active metabolites. T1/2 — 1 h, in the terminal phase-15 h (due to reverse diffusion from the tissues). It is excreted by the kidneys, with repeated use it can accumulate. Against the background of severe hepatic impairment, the clearance decreases, and in chronic renal failure, the excretion of metabolites is disrupted.
Bromhexine-Akrikhin
Bromhexine
Inside, adults and children over 14 years — 8-16 mg 3 times a day, children under 14 years and patients weighing less than 50 kg-8 mg 3 times a day, children under 6 years - 4 mg 3 times a day.
Inside (regardless of food intake), adults and children over 14 years — 8-16 mg (2-4 hours).spoons) 3 times a day, for children from 6 to 14 years — 4-8 mg (1-2 hours).spoons) 3 times a day, children from 2 to 6 years — 2-4 mg (1/2–1 hour).spoon) 3 times a day, for children under 2 years - 2 mg (1/2 teaspoon) 3 times a day. The course of treatment is from 4 to 28 days. In the course of treatment, it is recommended to consume a sufficient amount of liquid.
R05CB02 Bromhexine
