Chronic hepatitis and cirrhosis of the liver of any origin, peptic ulcer of the stomach and duodenum (including in remission), type I and II diabetes mellitus, gout, hypersensitivity.
Other hypolipidemic agents (statins, fibrates) may increase the risk of developing myopathies. Possible interaction with antihypertensive agents, acetylsalicylic acid, anticoagulants.
Rarely — redness of the face, dry skin, itching, burning sensation, headache. Possible exacerbation of peptic ulcer of the stomach and duodenum, a transient increase in the activity of transaminases, the concentration of glucose and uric acid in the blood plasma.
CHD (chronic forms, condition after a myocardial infarction, unstable angina, atherosclerotic cardiosclerosis, stable angina of tension and rest), cerebral atherosclerosis and encephalopathy, atherosclerosis of the arteries of the lower extremities with the phenomena of chronic arterial insufficiency of the I-III degree, microangiopathies (inflammatory, with scleroderma, Raynaud's syndrome), hyperlipidemia (especially in people with DR. risk factors for CHD (hyperlipidemia types IIa, IIb and IV according to WHO, but with total blood cholesterol up to 7.8 mmol/l (300 mg/dl), and / or triglycerides up to 4.6 mmol/l (400 mg/dl), as well as with isolated or combined hypoalphacholesterolemia-less than 1 mmol/l (40 mg/dl)
Nicotinic acid normalizes the content of blood lipoproteins, reduces the level of total cholesterol, LDL, triglycerides and increases the level of HDL, has an anti-atherogenic effect, vasodilating effect (especially against small vessels), improves microcirculation, has a weak anticoagulant effect.
It is absorbed within 6-8 hours, as nicotinic acid is gradually and evenly released from the tablet. During the first hour, about 50% is absorbed, by the eighth hour-about 96%. Degradation products are excreted by the kidneys.
Acinic (Nicotinic Acid)
Nicotinic Acid
Inside. The initial dose is 500 mg once a day (1 table.) during the first week and 500 mg 2 times (1 table. morning and evening) - in the second week of treatment. Starting from the third week-500 mg 3 times a day. After 3 months of treatment, it is necessary to conduct a biochemical blood test. With insufficient hypolipidemic effect, treatment continues at a dose of 1.5-2 g/day for 1-2 months. With a sufficient hypolipidemic effect, you can take a monthly break in treatment, after which you can resume taking the drug according to the above scheme for 2.5-3 months. The optimal dose of the drug is 1.5-2 g/day. To increase the level of alpha-cholesterol in isolated hypoalphacholesterolemia-1 g/day. With moderate dyslipidemia in people with risk factors, but without a pronounced clinical CHD — 0.5 -1 g/day. In the treatment of stenosing atherosclerosis of the arteries of the legs with the phenomena of chronic insufficiency of stage II-III — 3 g (according to 2 tables. 3 times a day)
