The following amounts have been found to be toxic orally. Toxicity manifestations depend on the age, dosage, size, and duration of administration.
Acute toxicity - single dose (25,000 Units/kg body weight)
Infant: 350,000 Units
Adult: Over 2 million Units
Chronic toxicity (4,000 Units/kg body weight for 6 to 15 months)
Infants 3 to 6 months old: 18,500 Units (water dispersed)/day for 1 to 3 months.
Adult: 1 million Units daily for three days; 50,000 Units daily for longer than 18 months; 500,000 Units daily for two months.
Hypervitaminosis A SyndromeThe treatment of hypervitaminosis A consists of immediate withdrawal of the vitamin along with symptomatic and supportive treatment.
See OVERDOSAGE section. Anaphylactic shock and death have been reported using the intravenous route. Allergic reactions have been reported rarely with administration of A/Fish Oil® Parenteral (vitamin a) including one case of an anaphylactoid type reaction.