Tenox contains amlodipine, an antihypertensive and vasodilator agent, and is registered in 13 countries concentrated across Central and Eastern Europe with a small additional presence further afield. The brand is used in the management of hypertension and angina pectoris, two cardiovascular conditions where amlodipine is a long-established treatment option internationally.
Amlodipine is classified within a group of medications described in the structured data on this page as antihypertensive, hypotensive, antianginal, antispasmodic, and vasodilator. In practical terms, it is prescribed both for the long-term control of elevated blood pressure and for the prevention of angina episodes in patients with stable ischaemic heart disease. The full list of registered indications recognised in the markets where Tenox is sold is shown in the structured section further down this page.
The country footprint for Tenox leans heavily into Central and Eastern Europe and the Balkans — markets where it is available include Poland, Russia, Hungary, Serbia, and Singapore, the latter being the principal outlier from the regional cluster. Travellers and expatriates moving outside this footprint will generally not find Tenox by name on pharmacy shelves, but amlodipine itself is one of the most widely distributed cardiovascular molecules in the world and circulates under many different brand names in essentially every regulated market.
Other medications in the same broader cardiovascular class are also available globally under various molecules and brand names, and a local pharmacist can identify what is stocked in a given country. Decisions about starting amlodipine, substituting Tenox for another product, or adjusting an existing regimen belong with a healthcare provider familiar with the patient's cardiovascular history.
None stated.
Reproductive toxicology
Reproductive studies in rats and mice have shown delayed date of delivery, prolonged duration of labour and decreased pup survival at dosages approximately 50 times greater than the maximum recommended dosage for humans based on mg/kg.
Impairment of fertility
There was no effect on the fertility of rats treated with Tenox (males for 64 days and females 14 days prior to mating) at doses up to 10 mg/kg/day (8 times* the maximum recommended human dose of 10 mg on a mg/m2 basis). In another rat study in which male rats were treated with Tenox besilate for 30 days at a dose comparable with the human dose based on mg/kg, decreased plasma follicle-stimulating hormone and testosterone were found as well as decreases in sperm density and in the number of mature spermatids and Sertoli cells.
Carcinogenesis, mutagenesis
Rats and mice treated with Tenox in the diet for two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25, and 2.5 mg/kg/day showed no evidence of carcinogenicity. The highest dose (for mice, similar to, and for rats twice* the maximum recommended clinical dose of 10 mg on a mg/m2 basis) was close to the maximum tolerated dose for mice but not for rats.
Mutagenicity studies revealed no drug related effects at either the gene or chromosome levels.
*Based on patient weight of 50 kg
No special requirements.
Tenox is prescribed for the management of hypertension and angina pectoris. As an antihypertensive and vasodilator, it is used both for the long-term control of elevated blood pressure and for the prevention of angina episodes associated with stable ischaemic heart disease. The structured indication block below this introduction details the registered uses recognised by national regulators in the markets where Tenox is sold.
Tenox contains amlodipine, classified among antihypertensive, antianginal, and vasodilator agents. Amlodipine is one of the most widely used cardiovascular molecules in the world and circulates internationally under a large number of brand names. The molecule itself is the same regardless of the brand on the box, although formulations and prescription pathways differ between regulatory regimes.
Tenox is registered in 13 countries, with a footprint concentrated in Central and Eastern Europe and the Balkans. Examples include Poland, Russia, Hungary, Romania, Croatia, Lithuania, and Singapore. Outside this cluster the brand is largely unfamiliar, but amlodipine as an active ingredient is broadly available worldwide — a local pharmacist can confirm which amlodipine-containing products are stocked in your country.
Amlodipine is sold under many brand names internationally, both as single-ingredient products and as components of fixed-dose cardiovascular combinations. Other medications in the broader antihypertensive and vasodilator categories also exist, although molecules within these groups are not freely interchangeable and differ in their clinical positioning. To identify a local equivalent, search the active ingredient amlodipine on Pill2Trip or ask a pharmacist.
Yes. Tenox is a prescription cardiovascular medication, and amlodipine therapy is calibrated to a patient's blood pressure profile, cardiac history, and concurrent medications. Prescription requirements and available brands differ between countries, which is particularly relevant for travellers and people relocating across regulatory regimes. Any decision to start, stop, or substitute amlodipine should be made together with a healthcare provider familiar with the patient.
