Hypersensitivity towards Calcium dobesilate (Swift CRM) and/or sulfites.
See also:
What is the most important information I should know about Hydrocortisone (Swift CRM)?
You should not use this medication if you are allergic to Hydrocortisone (Swift CRM), or if you have a fungal infection anywhere in your body.
Before taking Hydrocortisone (Swift CRM), tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
Do not receive a "live" vaccine while you are taking Hydrocortisone (Swift CRM). Vaccines may not work as well while you are taking a steroid.
Do not stop using Hydrocortisone (Swift CRM) suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.
Severe bleeding, shock, hypotension, infection of the proposed injection site, marked bradycardia, cardiogenic shock, severe forms of chronic heart failure, SSS in elderly patients, AV-block II and III degree (except in cases when the probe was introduced to stimulate the ventricles), severe liver function abnormalities.
For subarachnoid anesthesia - complete heart block, bleeding, hypotension, shock, infection of the venue lumbar puncture, septicemia.
Increased sensitivity to Lignocaine (Swift CRM) Haffkine Bio-Pharmaceutical Corporation and other amide type local anesthetics.
See also:
What is the most important information I should know about Zinc (Swift CRM)?
Hypersensitivity to any of the ingredients of Zinc (Swift CRM).
Rarely in sensitive persons some nausea or gastric discomfort may occur but this rapidly disappears if the dose is decreased.
See also:
What are the possible side effects of Hydrocortisone (Swift CRM)?
Applies to Hydrocortisone (Swift CRM) topical: topical application cream, topical application ointment
Other dosage forms:
In addition to its needed effects, some unwanted effects may be caused by Hydrocortisone (Swift CRM) topical (the active ingredient contained in Hydrocortisone (Swift CRM) with Aloe). In the event that any of these side effects do occur, they may require medical attention.
Major Side EffectsYou should check with your doctor immediately if any of these side effects occur when taking Hydrocortisone (Swift CRM) topical:
More common:
Some of the side effects that can occur with Hydrocortisone (Swift CRM) topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common:
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Approximately 16% of patients can be expected to experience adverse reactions. These are localised reactions due to the nature of the medicinal product.
The most commonly reported adverse reactions were administration site reactions (eg, burning, dermatitis, erythema, pruritus, rash, skin irritation and vesicles).
Adverse reactions that have been reported in studies of post-herpetic neuralgia patients receiving the plaster. They are listed by system organ class and frequency. Frequencies are defined as very common (≥1/10); common (≥1/100-<1/10); uncommon (≥1/1,000-<1/100); rare (≥1/10,000-<1/1000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Skin and Subcutaneous Tissue Disorders: Uncommon: Skin lesion.
Injury, Poisoning and Procedural Complications: Uncommon: Skin injury.
General Disorders and Administration Site Conditions: Very common: Administration site reactions.
The following reactions have been observed in patients receiving the plaster under post-marketing conditions: Injury, Poisoning and Procedural Complications: Very rare: Open wound.
Immune System Disorders: Very rare: Anaphylactic reaction, hypersensitivity.
All adverse reactions were predominantly of mild and moderate intensity. Of those <5% lead to treatment discontinuation.
Systemic adverse reactions following the appropriate use of the plaster are unlikely since the systemic concentration of Lignocaine (Swift CRM) is very low. Systemic adverse reactions to Lignocaine (Swift CRM) are similar in nature to those observed with other amide local anaesthetic agents.
See also:
What are the possible side effects of Zinc (Swift CRM)?
Applies to Zinc (Swift CRM) sulfate: capsules, tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Swift CRM) sulfate (the active ingredient contained in Zinc (Swift CRM))
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.
Microangiopathies, in particular diabetic retinopathy.
Clinical signs of chronic venous insufficiency in the lower limbs (pain, cramps, paresthesia, oedema stasis dermatosis), as adjuvant in superficial thrombophlebitis, haemorrhoidal syndrome, microcirculation disorders of arteriovenous origin.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramusculat use of Solu-Hydrocortisone (Swift CRM) Sterile Powder is indicated as follows:
Allergic states
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.
Dermatologic diseases
Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
Endocrine disorders
Primary or secondary adrenocortical insufficiency (Hydrocortisone (Swift CRM) or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
Gastrointestinal diseases
To tide the patient over a critical period of the disease in regional enteritis (systemic therapy) and ulcerative colitis.
Hematologic disorders
Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond Blackfan anemia), idiopathic thrombocytopenic purpura in adults (intravenous administration only; intramuscular administration is contraindicated), pure red cell aplasia, select cases of secondary thrombocytopenia.
Miscellaneous
Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy.
Neoplastic diseases
For the palliative management of leukemias and lymphomas.
Nervous System
Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor, or craniotomy.
Ophthalmic diseases
Sympathetic ophthalmia, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids.
Renal diseases
To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome, or that due to lupus erythematosus.
Respiratory diseases
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
Rheumatic disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, temporal arteritis, polymyositis, and systemic lupus erythematosus.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.In cardiological practice: treatment and prevention of ventricular arrhythmias (extrasystoles, tachycardia, atrial flutter, atrial fibrillation), including in acute myocardial infarction, implantation of artificial pacemaker in the glycoside intoxication, narcosis.
Anaesthesia: terminal, infiltration, conduction, spinal (epidural) anesthesia in surgery, obstetrics and gynecology, urology, ophthalmology, dentistry, otolaryngology, blockade of peripheral nerves and ganglion.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Patients with deficiency of B-complex vitamins, vitamin C and Zinc (Swift CRM) or where supplementation of these vitamins and Zinc (Swift CRM) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.
See also: Entyvio
Hydrocortisone (Swift CRM) is a steroid medicine that is used in the treatment of many different conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, multiple sclerosis, or lung disorders.
Hydrocortisone (Swift CRM) is also used to replace steroids in people with adrenal insufficiency (decreased production of natural steroids by the adrenal glands).
Hydrocortisone (Swift CRM) affects your immune system and is often used to treat certain blood cell disorders such as anemia (low red blood cells) or thrombocytopenia (low platelets).
Hydrocortisone (Swift CRM) is also used in the treatment of certain cancers such as leukemia, lymphoma, and multiple myeloma.
Hydrocortisone (Swift CRM) may also be used for purposes not listed in this medication guide.
Zinc (Swift CRM) is a naturally occurring mineral. Zinc (Swift CRM) is important for growth and for the development and health of body tissues.
Zinc (Swift CRM) sulfate is used to treat and to prevent Zinc (Swift CRM) deficiency.
Zinc (Swift CRM) sulfate may also be used for purposes not listed in this medication guide.
Calcium dobesilate (Swift CRM) is 2,5-dihydroxy benzene sulfonic acid calcium salt. Molecular formula of Calcium dobesilate (Swift CRM) is C12H10CaO10S2. Molecular weight is 418.41 and melting point is 300°C. Color changes to pink upon exposure to air. Very soluble in water and alcohol, practically insoluble in ether, benzene, chloroform. Therapeutic Category: Vasotropic.
Solu-Hydrocortisone (Swift CRM) 100 mg contains Hydrocortisone (Swift CRM) sodium succinate equivalent to Hydrocortisone (Swift CRM) 100 mg, monobasic sodium phosphate 1 mg, dibasic sodium 9 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Swift CRM) 100 mg/2 mL contains Hydrocortisone (Swift CRM) sodium succinate equivalent to Hydrocortisone (Swift CRM) 100 mg/2 mL, monobasic sodium phosphate 1 mg, dibasic sodium 10 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Swift CRM) 250 mg/2 mL contains Hydrocortisone (Swift CRM) sodium succinate equivalent to Hydrocortisone (Swift CRM) 250 mg/2 mL, monobasic sodium phosphate 2 mg, dibasic sodium phosphate 25 mg and sodium hydroxide 10%.
Solu-Hydrocortisone (Swift CRM) 500 mg/4 mL contains Hydrocortisone (Swift CRM) sodium succinate equivalent to Hydrocortisone (Swift CRM) 500 mg/4 mL, monobasic sodium phosphate 5 mg, dibasic sodium phosphate 52 mg and sodium hydroxide 10%.
Hydrocortisone (Swift CRM) sodium succinate or pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy; monosodium salt,(11β) is an anti-inflammatory adrenocortical steroid. This highly water-soluble sodium succinate ester of Hydrocortisone (Swift CRM) permits the immediate IV administration of high doses of Hydrocortisone (Swift CRM) in a small volume of diluent and is particularly useful where high blood levels of Hydrocortisone (Swift CRM) are required rapidly.
When necessary, the pH of Solu-Hydrocortisone (Swift CRM) was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7-8.
Each 10 cm x 14 cm plaster contains Lignocaine (Swift CRM) 700 mg (5% w/w). Lignopad also contains the following excipients: Self-adhesive layer: Methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), glycerol, crystallising liquid sorbitol, carmellose sodium, urea, heavy kaolin, tartaric acid, gelatin, polyvinyl alcohol, aluminum glycinate, disodium edetate, polyacrylic acid, sodium polyacrylate, purified water. Backing fabric and release liner: Polyethylene terephthalate (PET).
Zinc (Swift CRM) Capsule: Each capsule contains Zinc (Swift CRM) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, vitamin B12 (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, folic acid 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.
Zinc (Swift CRM) Syrup: Each 5 mL contains Zinc (Swift CRM) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.
Use Hydrocortisone (Swift CRM) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Hydrocortisone (Swift CRM) solution.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.It is used to reduce the viscosity of blood thus restoring normal flow of blood and also prevents platelet hyper aggregation.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Hydrocortisone (Swift CRM) is a natural substance (corticosteroid hormone) made by the adrenal gland. It is used to treat conditions such as arthritis, blood/hormone/immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. It decreases your immune system's response to various diseases to reduce symptoms such as pain, swelling and allergic-type reactions.
Hydrocortisone (Swift CRM) is also used to treat low Hydrocortisone (Swift CRM) levels caused by diseases of the adrenal gland (such as Addison's disease, adrenocortical insufficiency). Corticosteroids are needed in many ways for the body to function well. They are important for salt and water balance and keeping blood pressure normal.
How to use Hydrocortisone (Swift CRM)Take this medication by mouth, with food or milk to prevent stomach upset, exactly as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.
Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. Your doctor may direct you to take Hydrocortisone (Swift CRM) 1 to 4 times a day or take a single dose every other day. It may help to mark your calendar with reminders or use a pill box.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.
If you have used Hydrocortisone (Swift CRM) regularly for a long time or in high doses, you may have withdrawal symptoms if the drug is suddenly stopped. To prevent withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. See also Precautions section.
Tell your doctor if your condition persists or worsens.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Pulseless ventricular fibrillation or ventricular tachycardia, epidural anaesthesia, spinal anaesthesia, surface anaesthesia, percutaneous infiltration anaesthesia, peripheral nerve block.
Diabetic Microangiopathy: Because of chronic nature of the illness, it is preferable to determine the dosage for each case individually. Initial Treatment: 1.5-2 g/day according to the severity of the case. Maintenance Treatment: 1 g/day.
Other Vascular Disorders: 0.5-1 g/day according to the severity of the case.
The initial dosage of Hydrocortisone (Swift CRM) Tablets may vary from 20 mg to 240 mg of Hydrocortisone (Swift CRM) per day depending on the specific disease entity being treated. In situations of less severity lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, Hydrocortisone (Swift CRM) should be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of Hydrocortisone (Swift CRM) for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually, rather than abruptly.
Multiple SclerosisIn treatment of acute exacerbations of multiple sclerosis, daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for 1 month have been shown to be effective (20 mg of Hydrocortisone (Swift CRM) is equivalent to 5 mg of prednisolone).
How suppliedHydrocortisone (Swift CRM) Tablets are available in the following strengths and package sizes:
5 mg (white, round, scored, imprinted Hydrocortisone (Swift CRM) 5) Bottles of 50 NDC 0009-0012-01
10 mg (white, round, scored, imprinted Hydrocortisone (Swift CRM) 10) Bottles of 100 NDC 0009-0031-01
20 mg (white, round, scored, imprinted Hydrocortisone (Swift CRM) 20) Bottles of 100 NDC 0009-0044-01
Store at controlled room temperature 20° to 25°C (68° to 77°F).
Distributed by: Pharmacia & Upjohn Company, Division of Pfizer Inc., NY, NY 10017. Revised: Sep 2013
Adults and
Elderly:
The painful area should be covered with the plaster once daily for up to 12 hrs within a 24 hrs period. Only the number of plasters that are needed for an effective treatment should be used. When needed, the plasters may be cut into smaller sizes with scissors prior to removal of the release liner. In total, not >3 plasters should be used at the same time.The plaster must be applied to intact, dry, non-irritated skin (after healing of the shingles). Each plaster must be worn no longer than 12 hrs. The subsequent plaster-free interval must be at least 12 hrs. The plaster can be applied during the day or during the night.
The plaster must be applied to the skin immediately after removal from the sachet and following removal of the release liner from the gel surface. Hairs in the affected area must be cut off with a pair of scissors (not shaved).
Treatment outcome should be re-evaluated after 2-4 weeks. If there has been no response to Lignopad medicated plaster after this period or if any relieving effect can solely be related to the skin protective properties of the plaster, treatment must be discontinued as potential risks may outweigh benefits in this context. Long-term use of Lignopad medicated plaster in clinical studies showed that the number of plasters used decreased over time. Therefore, treatment should be reassessed at regular intervals to decide whether the amount of plasters needed to cover the painful area can be reduced, or if the plaster-free period can be extended.
Renal Impairment: In patients with mild or moderate renal impairment a dosage adjustment is not required. Lignopad medicated plaster should be used with caution in patients with severe renal impairment.
Hepatic impairment: In patients with mild or moderate hepatic impairment a dosage adjustment is not required. Lignopad medicated plaster should be used with caution in patients with severe hepatic impairment.
Paediatric population: The safety and efficacy of Lignopad medicated plaster in children <18 years has not been established. No data are available.
Zinc (Swift CRM) 1 mg/mL (Zinc (Swift CRM) Chloride Injection, USP) contains 1 mg Zinc (Swift CRM)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Swift CRM)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Swift CRM)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Swift CRM)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Swift CRM)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Swift CRM) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Swift CRM).
For full term infants and children up to 5 years of age, 100 mcg Zinc (Swift CRM)/kg/day
(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Swift CRM)/kg/day (0.3 mL/kg/day) is suggested.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
How suppliedZinc (Swift CRM) 1 mg/mL (Zinc (Swift CRM) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).
Store at 20 to 25°C (68 to 77°F).
HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004
No interaction is known.
Incompatibilities: No incompatibility is known.
See also:
What other drugs will affect Hydrocortisone (Swift CRM)?
With simultaneous use of Hydrocortisone (Swift CRM) increases the toxicity of cardiac glycosides (because of the emerging hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in blood plasma (with the abolition of Hydrocortisone (Swift CRM) concentration of salicylates in the blood increases, and increases the risk of side effects); with paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of Hydrocortisone (Swift CRM) as a result of inhibition of its metabolism; with ketoconazole - increased side effects of Hydrocortisone (Swift CRM) as a result of reduction of its clearance.
Hydrocortisone (Swift CRM) Micronised Xepa-Soul Pattinson reduces the effectiveness of hypoglycemic; intensifies the effect of indirect anticoagulants of coumarin derivatives.
Hydrocortisone (Swift CRM) reduces the effect of vitamin D on the absorption of calcium ions into the lumen of the intestine. Ergocalciferol and parathyroid hormone hinder the development of osteopathy caused by GCS.
Hydrocortisone (Swift CRM) Micronised Xepa-Soul Pattinson increases the metabolism of isoniazid, meksiletina (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid reduces the concentration of praziquantel in blood.
Hydrocortisone (Swift CRM) in high doses reduces the effect somatropina.
Hypokalemia caused by GCS, may increase the severity and duration of muscle blockade on the background of muscle relaxants.
Antacids reduce the absorption of the GCS.
At simultaneous application with SCS thiazides, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - swelling and increase blood pressure.
NSAIDs and ethanol increases the risk of gastrointestinal ulcerations and bleeding, in combination with NSAIDs to treat arthritis may reduce the dose of GCS due to summation of therapeutic effect. Indomethacin displacing the SCS from its association with albumin, increases the risk of its side effects.
Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.
The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampin) due to increased rate of metabolism of these substances.
Inhibitors of the function of the adrenal cortex (including mitotan) may necessitate higher doses of GCS.
Clearance GCS increased against the background of preparations of thyroid hormones.
Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.
Estrogens (including oral contraceptives containing estrogen) reduce the clearance of GKS, lengthens T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne promotes the simultaneous use of other steroid hormone funds - androgens, estrogens, anabolic steroids, oral contraceptives.
Tricyclic antidepressants may increase the severity of depression caused by GCS (not shown for the treatment of these side effects).
The risk of developing cataracts increases with the application against other GCS antipsychotic funds (neuroleptics), carbutamide and azathioprine. Simultaneous of Hydrocortisone (Swift CRM) Micronised Xepa-Soul Pattinson with the appointment of m-cholinoblockers, as well as with means having m-anticholinergic action (including antihistamines, tricyclic antidepressants), with nitrates improves the intraocular pressure.
With simultaneous application of SCS with live vaccines and antiviral compared to other types of immunization increases the risk of activation of viruses and development of infections.
Beta-blockers increase the risk of bradycardia and hypotension. Norepinephrine and beta-blockers by reducing hepatic blood flow decrease (increased toxicity), isadrine and glucagon - increase the clearance of lidocaine. Cimetidine increases the plasma concentration of Lignocaine (Swift CRM) Haffkine Bio-Pharmaceutical Corporation (displaces from its association with proteins and slows inactivation in the liver). Barbiturates causing induction of microsomal enzymes stimulate the degradation of lidocaine and reduce its activity. Anticonvulsants (hydantoin derivatives) accelerate the biotransformation in the liver (decreased concentration in the blood), for IV injections it may increases cardiodepressive action of lidocaine. Antiarrhythmics (amiodarone, verapamil, quinidine, aymalin) potentiate cardiac depression. Combination with novocainamide may cause CNS excitement and hallucinations. Lignocaine (Swift CRM) Haffkine Bio-Pharmaceutical Corporation strengthens the inhibitory effect of anesthesia (hexobarbital, thiopental sodium), hypnotics and sedatives on the respiratory center, weakens the cardiac effects of digitoxin, enhances muscle relaxation caused by drugs curare like (possible paralysis of respiratory muscles). MAO inhibitors prolong local anesthesia.
See also:
What other drugs will affect Zinc (Swift CRM)?
Pyridoxine reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for pyridoxine.
Absorption of cyanocobalamin from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H2-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.
Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia.
Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and folic acid antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; folic acid may decrease serum-phenytoin concentrations.
There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.
Ascorbic acid may increase the absorption of iron-deficiency states.
Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.
The absorption of Zinc (Swift CRM) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Swift CRM) supplements reduce the absorption of copper, ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.
