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Suplasyn

Suplasyn contains sodium hyaluronate and is registered in 10 countries spread across several regions rather than clustered in one — the footprint includes Canada, Mexico, Egypt, South Africa, Indonesia, Malaysia, Thailand, Singapore, Colombia, and Tunisia. That spread means travellers may encounter the brand in some markets and not others, even within the same continent.

Sodium hyaluronate is the sodium salt of hyaluronic acid, and the active ingredient is positioned across several categories on this page: it is associated with analgesic and anti-inflammatory action, with corrective action on bone and cartilaginous tissue, and with the broader group of agents used in disorders of the musculoskeletal system. The registered uses listed for Suplasyn also include surgical contexts — cataract surgery, cataract extraction, glaucoma procedures, and corneal transplantation — reflecting the well-established role of sodium hyaluronate preparations in ophthalmic surgery as well as in joint and soft-tissue indications.

Travellers and expatriates familiar with Suplasyn from one country may find that the same brand is not stocked in their destination, even when sodium hyaluronate itself is widely available. The molecule circulates internationally under many brand names and in different formulations, since it is used both as a surgical aid in ophthalmology and as a treatment within musculoskeletal medicine. A local pharmacist or specialist is usually the most reliable route to identifying the appropriate regional product, as the right preparation depends heavily on the clinical context.

Other agents acting in the same broad categories — analgesic, anti-inflammatory, and musculoskeletal — are also available globally, but they are not interchangeable with sodium hyaluronate without medical guidance. Anyone considering Suplasyn, already using it, or seeking a local equivalent abroad should make that decision together with a qualified healthcare provider.

Countries
Canada Colombia Egypt Indonesia Malaysia Mexico Singapore South Africa Thailand Tunisia
Diseases
Surgery Cataract Glaucoma Cataract extraction Corneal transplant
Ingredients
Sodium hyaluronate
Drug Actions
Analgesic Anti-inflammatory Corrective metabolism of bone and cartilaginous tissue Other drugs for disorders of the musculo-skeletal system

Drugs with the same active ingredients

Artflex Cystistat Dropstar Dropstar p Fusimed Hialudorf Hialudorf hd Hyabak Hyalart Hyalofill-f Hyalogran Iuronico biotic Iuronico biotic (sodium hyaluronate,sulfadiazine) Iuronicoderm Maxiostenil Maxiostenil plus Miniostenil Viscoderm Yusin Curiosin

Overdose

No information provided.

Contraindications

At present there are no known contraindications to the use of the Suplasyn OVD when used as recommended.

Undesirable effects

The Suplasyn OVD is extremely well tolerated after injection into human eyes. A transient rise of intraocular pressure postoperatively has been reported in some cases.

In posterior segment surgery intraocular pressure rises have been reported in some patients, especially in aphakic diabetics, after injection of large amounts of the Suplasyn OVD.

Rarely, postoperative inflammatory reactions (iritis, hypopyon) as well as incidents of corneal edema and corneal decompensation have been reported. Their relationship to the Suplasyn OVD has not been established.

Therapeutic indications

Uses

The Suplasyn OVD is indicated for use as a surgical aid in cataract extraction (intra- and extracapsular), IOL implantation, corneal transplant, glaucoma filtration and retinal attachment surgery.

In surgical procedures in the anterior segment of the eye, instillation of the Suplasyn OVD serves to maintain a deep anterior chamber during surgery, allowing for efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues.

Furthermore, its viscoelasticity helps to push back the vitreous face and prevent formation of a postoperative flat chamber.

In posterior segment surgery the Suplasyn OVD serves as a surgical aid to gently separate, maneuver and hold tissues.The Suplasyn OVD creates a clear field of vision thereby facilitating intra- and post-operative inspection of the retina and photocoagulation.

Qualitative and quantitative composition

Sodium Hyaluronate

Special warnings and precautions for use

WARNINGS

Included as part of the PRECAUTIONS section.

PRECAUTIONS

Those normally associated with the surgical procedure being performed.

Overfilling the anterior or posterior segment of the eye with the Suplasyn OVD may cause increased intraocular pressure, glaucoma, or other ocular damage.

Postoperative intraocular pressure may also be elevated as a result of preexisting glaucoma, compromised outflow and by operative procedures and sequelae thereto, including enzymatic zonulysis, absence of an iridectomy, trauma to filtration structures, and by blood and lenticular remnants in the anterior chamber. Since the exact role of these factors is difficult to predict in any individual case, the following precautions are recommended:

  • Don’t overfill the eye chambers with the Suplasyn OVD (except in glaucoma surgery - See Applications section).
  • In posterior segment procedures in aphakic diabetic patients special care should be exercised to avoid using large amounts of the Suplasyn OVD.
  • Remove some of the Suplasyn OVD by irrigation and/or aspiration at the close of surgery (except in glaucoma surgery - See Applications section).
  • Carefully monitor the intraocular pressure, especially during the immediate postoperative period. If significant rises are observed, treat with appropriate therapy.

Care should be taken to avoid trapping air bubbles behind the Suplasyn OVD.

Because the Suplasyn OVD is a highly purified fraction extracted from avian tissues and is known to contain minute amounts of protein, the physician should be aware of potential risks of the type that can occur with the injection of any biological material.

Because of reports of an occasional release of minute rubber particles, presumably formed when the diaphragm is punctured, the physician should be aware of this potential problem. Express a small amount of the Suplasyn OVD from the syringe prior to use, and carefully examine the remainder as it is injected.

Reprocessed cannulas should not be used.

Sporadic reports have been received indicating that the Suplasyn OVD may become ”cloudy” or form a slight precipitate following instillation into the eye.The clinical significance of these reports, if any, is not known since the majority received to date do not indicate any harmful effects on ocular tissues.The physician should be aware of this phenomenon and, should it be observed, remove the cloudy or precipitated material by irrigation and/or aspiration.

In vitro laboratory studies suggest that this phenomenon may be related to interactions with certain concomitantly administered ophthalmic medications.

Use only if solution is clear.

Dosage (Posology) and method of administration

Applications Cataract Surgery - IOL Implantation

A sufficient amount of the Suplasyn OVD is slowly, and carefully introduced (using a cannula or needle) into the anterior chamber.

Injection of the Suplasyn OVD can be performed either before or after delivery of the lens. Injection prior to lens delivery will, however, have the additional advantage of protecting the corneal endothelium from possible damage arising from the removal of the cataractous lens5.The Suplasyn OVD may also be used to coat surgical instruments and the IOL prior to insertion.

Additional Suplasyn OVD can be injected during surgery to replace any Suplasyn OVD lost during surgical manipulation (see PRECAUTIONS section).

Glaucoma Filtration Surgery

In conjunction with performing of the trabeculectomy, the Suplasyn OVD is injected slowly and carefully through a corneal paracentesis to reconstitute the anterior chamber. Further injection of the Suplasyn OVD can be continued allowing it to extrude into the subconjunctival filtration site and through and around the sutured outer scleral flap.

Corneal Transplant Surgery

After removal of the corneal button, the anterior chamber is filled with the Suplasyn OVD.The donor graft can then be placed on top of the bed of Suplasyn OVD and sutured in place.Additional Suplasyn OVD may be injected to replace the Suplasyn OVD lost as a result of surgical manipulation (see PRECAUTIONS section).The Suplasyn OVD has also been used in the anterior chamber of the donor eye prior to trepanation to protect the corneal endothelial cells of the graft5.

Retinal Attachment Surgery

The Suplasyn OVD is slowly introduced into the vitreous cavity. By directing the injection, the Suplasyn OVD can be used to separate membranes (e.g. epiretinal membranes) away from the retina for safe excision and release of traction.The Suplasyn OVD also serves to maneuver tissues into the desired position, e.g. to gently push back a detached retina or unroll a retinal flap, and aids in holding the retina against the sclera for reattachment.

Instructions Sterile Opening Technique

Tear off the paper covering.

Bend the plastic backwards at the central indentation so as to fully expose the white plastic rod.

Dislodge syringe and place onto sterile field.

Assembly

Press the vial completely into the holder so that the needle perforates the membrane.

Important

Perforate the membrane before screwing on the plastic rod.

Remove the plastic rod.

Screw the plastic rod into the blue plunger.

Connect the cannula and check for proper function.

Store at 2 to 8°C (36 to 46°F). For single use only

Frequently asked questions

What is Suplasyn used for?

Suplasyn is used in contexts involving ocular surgery — including cataract extraction, glaucoma surgery, and corneal transplantation — and is also positioned within the broader category of products acting on bone and cartilaginous tissue. Sodium hyaluronate preparations are used across both ophthalmic-surgical and musculoskeletal categories internationally. The structured indication block further down this page lists each registered use as recognised by the regulators in the markets where Suplasyn is sold.

Which active substance is in Suplasyn?

Suplasyn contains sodium hyaluronate, the sodium salt of hyaluronic acid. It is classified across categories that include analgesic, anti-inflammatory, and corrective action on bone and cartilaginous tissue. Sodium hyaluronate is used worldwide in both ophthalmic-surgical and musculoskeletal preparations, and the same active ingredient circulates internationally under a variety of brand names depending on the country and the formulation.

In how many countries is Suplasyn available?

Suplasyn is registered in 10 countries, spanning several regions rather than concentrated in one. Examples include Canada, Indonesia, Egypt, Mexico, Singapore, South Africa, and Thailand. The footprint is geographically broad but selective within each region, so a traveller may or may not find the specific brand on a local pharmacy shelf. If your country is not listed here, a local pharmacist can confirm whether sodium hyaluronate is available under another name.

Are there other medications with the same active ingredient as Suplasyn?

Sodium hyaluronate is sold under numerous brand names internationally, in both ophthalmic-surgical preparations and products targeting joint and cartilaginous tissue. Other agents within the broader categories listed for Suplasyn — analgesics, anti-inflammatories, and products for musculoskeletal disorders — also exist worldwide, though they are not directly interchangeable. To identify a regional product containing sodium hyaluronate, search the active ingredient on Pill2Trip or speak with a pharmacist.

Should I consult a doctor before taking Suplasyn?

Yes. Sodium hyaluronate preparations are typically administered in clinical settings — particularly in the context of ocular surgery — or used as part of a managed treatment plan for joint and cartilaginous conditions. Prescription rules, available formulations, and clinical pathways differ between countries, which is especially relevant for travellers and people relocating. Any decision involving Suplasyn or an equivalent sodium hyaluronate product should sit with a healthcare provider familiar with the patient.

Suplasyn

Available in 10 countries