See also:
What is the most important information I should know about Ascorbic acid (Septiva)?
There are no contraindications to the administration of Ascorbic acid (Septiva).
See also:
What is the most important information I should know about Biotin (Septiva)?
SINEQUAN is contraindicated in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.
SINEQUAN is contraindicated in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.
See also:
What is the most important information I should know about Folic acid (Septiva)?
Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Septiva) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Septiva) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.
See also:
What is the most important information I should know about Pyridoxine hydrochloride (Septiva)?
Contraindications for Vitamin B6 (Pyridoxine hydrochloride (Septiva))
Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.
See also:
What is the most important information I should know about Thiamine hydrochloride (Septiva)?
A history of sensitivity to Thiamine hydrochloride (Septiva) or to any of the ingredients in this drug is a contraindication.
See also:
What are the possible side effects of Ascorbic acid (Septiva)?
Applies to Ascorbic acid (Septiva): oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer
In addition to its needed effects, some unwanted effects may be caused by Ascorbic acid (Septiva) (the active ingredient contained in Ascorbic acid (Septiva) Quick Melts). In the event that any of these side effects do occur, they may require medical attention.
Severity: ModerateIf any of the following side effects occur while taking Ascorbic acid (Septiva), check with your doctor or nurse as soon as possible:
Less common or rare: - with high doses
Some of the side effects that can occur with Ascorbic acid (Septiva) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Less common or rare: - with high doses
See also:
What are the possible side effects of Biotin (Septiva)?
Adverse reactions associated with Biotin (Septiva) supplementation are rare in the medical literature; however, urticaria and gastrointestinal upset have been reported. As with any oral treatment, if patients experience any adverse reactions or side effects, they should inform their physicians immediately and discontinue use.
See also:
What are the possible side effects of Folic acid (Septiva)?
Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Septiva).
Folic acid (Septiva) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Septiva) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Septiva) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Septiva) therapy.
In an uncontrolled study, orally administered Folic acid (Septiva) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Septiva) daily.
CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.
See also:
What are the possible side effects of Methylcobalamin (Septiva)?
Tablet: Gastrointestinal: Symptoms eg, anorexia, nausea or diarrhea may occur infrequently.
Dermatological: Skin rash may occur rarely.
Others: Prolonged use of larger doses of Methylcobalamin (Septiva) is not recommended for patients whose occupation requires handling of mercury or its compounds.
Injection: Hypersensitivity: Use of Methylcobalamin (Septiva) should be discontinued if symptoms of hypersensitivity eg, eruptions, occur.
Others: Pain and induration may infrequently occur at the site of IM injection and headache, sweating or hot sensation may rarely occur.
See also:
What are the possible side effects of Niacinamide (Septiva)?
Applies to Niacinamide (Septiva): tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; dizziness; headache; itching; nausea; stomach upset; temporary feeling of warmth or flushing of the skin.
Seek medical attention right away if any of these SEVERE side effects occur while taking Niacinamide (Septiva):
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; changes in vision; dark urine; decreased urination; fast or irregular heartbeat; loss of appetite; muscle pain or weakness; numbness or persistent tingling of the skin; persistent nausea, vomiting, or general "unwell" feeling; severe or prolonged flushing of the skin; stomach pain; swelling of the hands, legs, or feet; vomit that looks like coffee grounds; yellowing of the skin or eyes.
See also:
What are the possible side effects of Pantothenic acid (Septiva)?
Contact dermatitis, Rash, Skin irritation, Urticaria
See also:
What are the possible side effects of Pyridoxine hydrochloride (Septiva)?
CNS
Neuropathy; unstable gait; drowsiness; somnolence.
EENT
Perioral numbness.
Miscellaneous
Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum Pyridoxine hydrochloride (Septiva) levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.
See also:
What are the possible side effects of Thiamine hydrochloride (Septiva)?
Applies to Thiamine hydrochloride (Septiva): capsule, solution, tablet, tablet enteric coated
As well as its needed effects, Thiamine hydrochloride (Septiva) may cause unwanted side effects that require medical attention.
Major Side EffectsIf any of the following side effects occur while taking Thiamine hydrochloride (Septiva), check with your doctor immediately:
Rare - Soon after receiving injection only
For systemic use of Ascorbic acid (Septiva) Atlantic Laboratories: prevention and treatment of hypo- and avitaminosis of Ascorbic acid (Septiva); providing increased need for Ascorbic acid (Septiva) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.
For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.skin disorders, Biotin (Septiva) deficiency, digestive disorders
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Folic acid (Septiva) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Septiva) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Tab: Treatment of peripheral neuropathies. Inj: Megaloblastic anemia due to vit B12 deficiency, peripheral neuropathies.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Oral
Pantothenic acid (Septiva) deficiency
Adult: Recommended daily dose: 4-7 mg/day.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.* Sideroblastic anaemia
* Treatment and prophylaxis of vitamin B6 deficiency states
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Fatigue mental and physical stress, vit B complex deficiency, prolonged diarrhoea and other GI disorders malnutrition, co-prescription with antibiotics.
Ascorbic acid (Septiva) (Ascorbic acid (Septiva)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Ascorbic acid (Septiva) is important for bones and connective tissues, muscles, and blood vessels. Ascorbic acid (Septiva) also helps the body absorb iron, which is needed for red blood cell production.
Ascorbic acid (Septiva) is used to treat and prevent Ascorbic acid (Septiva) deficiency.
Ascorbic acid (Septiva) may also be used for purposes not listed in this medication guide.
Biotin (Septiva) is a form of vitamin B found in foods. Biotin (Septiva) helps the body break down fats, carbohydrates, and other substances.
Biotin (Septiva) has been used in alternative medicine as a likely effective aid in treating or preventing Biotin (Septiva) deficiency. Biotin (Septiva) deficiency can be caused by malnutrition, rapid weight loss, long-term tube feeding, and other medical conditions.
Biotin (Septiva) has also been used to treat seborrhea (skin rash) in babies. However, research has shown that Biotin (Septiva) may not be effective in treating this condition.
Other uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.
It is not certain whether Biotin (Septiva) is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Biotin (Septiva) should not be used in place of medication prescribed for you by your doctor.
Biotin (Septiva) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Biotin (Septiva) may also be used for purposes not listed in this product guide.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Septiva) (vitamin B 9) is necessary for strong blood.
Lack of Folic acid (Septiva) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Septiva) for you.
Some conditions may increase your need for Folic acid (Septiva). These include:
In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Septiva).
Increased need for Folic acid (Septiva) should be determined by your health care professional.
Some studies have found that Folic acid (Septiva) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).
Claims that Folic acid (Septiva) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.
Injectable Folic acid (Septiva) is given by or under the direction of your health care professional. Another form of Folic acid (Septiva) is available without a prescription.
Methylcobalamin (Septiva) is a form of vitamin B12. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.
Methylcobalamin (Septiva) is used to treat vitamin B12 deficiency. Methylcobalamin (Septiva) is sometimes used in people with pernicious anemia, diabetes, and other conditions.
Methylcobalamin (Septiva) may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Treating acne.
Niacinamide (Septiva) gel is a vitamin B supplement. Exactly how Niacinamide (Septiva) gel works is unknown.
Vitamins are compounds that you must have for growth and health. They are needed in only small amounts and are usually available in the foods that you eat. Pantothenic acid (Septiva) (vitamin B 5) is needed for the breakdown of carbohydrates, proteins, and fats.
No problems have been found that are due to a lack of Pantothenic acid (Septiva) alone. However, a lack of one B vitamin usually goes along with a lack of others, so Pantothenic acid (Septiva) is often included in B complex products.
Claims that Pantothenic acid (Septiva) is effective for treatment of nerve damage, breathing problems, itching and other skin problems, and poisoning with some other drugs; for getting rid of or preventing gray hair; for preventing arthritis, allergies, and birth defects; or for improving mental ability have not been proven.
This vitamin is available without a prescription.
Pyridoxine hydrochloride (Septiva) is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.
Pyridoxine hydrochloride (Septiva) is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine hydrochloride (Septiva) injection is also used to treat some types of seizure in babies.
Pyridoxine hydrochloride (Septiva) taken by mouth (oral) is available without a prescription. Injectable Pyridoxine hydrochloride (Septiva) must be given by a healthcare professional.
Pyridoxine hydrochloride (Septiva) may also be used for purposes not listed in this medication guide.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Thiamine hydrochloride (Septiva) (vitamin B 1) is needed for the breakdown of carbohydrates.
Some conditions may increase your need for Thiamine hydrochloride (Septiva). These include:
Also, the following groups of people may have a deficiency of Thiamine hydrochloride (Septiva):
Increased need for Thiamine hydrochloride (Septiva) should be determined by your health care professional.
Lack of Thiamine hydrochloride (Septiva) may lead to a condition called beriberi. Signs of beriberi include loss of appetite, constipation, muscle weakness, pain or tingling in arms or legs, and possible swelling of feet or lower legs. In addition, if severe, lack of Thiamine hydrochloride (Septiva) may cause mental depression, memory problems, weakness, shortness of breath, and fast heartbeat. Your health care professional may treat this by prescribing Thiamine hydrochloride (Septiva) for you.
Thiamine hydrochloride (Septiva) may also be used for other conditions as determined by your health care professional.
Claims that Thiamine hydrochloride (Septiva) is effective for treatment of skin problems, chronic diarrhea, tiredness, mental problems, multiple sclerosis, nerve problems, and ulcerative colitis (a disease of the intestines), or as an insect repellant or to stimulate appetite have not been proven.
Injectable Thiamine hydrochloride (Septiva) is administered only by or under the supervision of your health care professional. Other forms of Thiamine hydrochloride (Septiva) are available without a prescription.
Once a medicine or dietary supplement has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, Thiamine hydrochloride (Septiva) is used in certain patients with the following medical conditions:
Each tablet contains Ascorbic acid (Septiva) 500 mg.
Ascorbic acid (Septiva) (Ascorbic acid (Septiva)) is a vitamin that is freely soluble in water. The superior formulation of Ascorbic acid (Septiva) (Ascorbic acid (Septiva)) assures substantial amounts per dose for prophylaxis and treatment of Ascorbic acid (Septiva) deficiencies. This preparation has a very delectable grape (Ascorbic acid (Septiva) Tablet) flavors.
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Septiva) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
Each ampoule also contains D-mannitol 50 mg as an additive. pH 5.3-7.3. Osmotic Pressure (to physiological saline): Approximately 1.
Mecobalamin is α-(5,6-dimethylbenzimidazolyl)-Co-methyl-cobamide.
Molecular Formula: C63H91CoN13O14P.
Molecular Weight: 1344.4.
Mecobalamin occurs as a dark red, odorless and almost tasteless crystal or crystalline powder. It is sparingly soluble in water, methanol and ethanol and practically insoluble in acetone, ether and chloroform. Mecobalamin is hygroscopic and decomposes upon exposure to light.
Niacinamide (Septiva), also called as nicotinamide (vitamin B3), is prescribed for the treatment of niacin deficiency disorders including pellagra. Niacinamide (Septiva) should not be used for treatment of hyperlipidemia.
Pyridoxine hydrochloride (Septiva) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride (Septiva) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Thiamine hydrochloride (Septiva) or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. Thiamine hydrochloride (Septiva) decomposes if heated. Thiamine hydrochloride (Septiva) was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. Thiamine hydrochloride (Septiva) plays a key role in intracellular glucose metabolism and it is thought that Thiamine hydrochloride (Septiva) inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine hydrochloride (Septiva) plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine hydrochloride (Septiva) cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.
Use Ascorbic acid (Septiva) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Ascorbic acid (Septiva) solution.
Use Folic acid (Septiva) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Folic acid (Septiva).
Use Niacinamide (Septiva) gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Niacinamide (Septiva) gel.
Use Pantothenic acid (Septiva) (vitamin b5) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Pantothenic acid (Septiva) (vitamin b5).
Use Pyridoxine hydrochloride (Septiva) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (Septiva) (vitamin b6).
Use Thiamine hydrochloride (Septiva) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Thiamine hydrochloride (Septiva).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Ascorbic acid (Septiva) (Ascorbic acid (Septiva)) is used to prevent or treat low levels of Ascorbic acid (Septiva) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra Ascorbic acid (Septiva). Low levels of Ascorbic acid (Septiva) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.
Ascorbic acid (Septiva) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).
How to use Ascorbic acid (Septiva)Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.
If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.
If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.
If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
Dosage is based on your medical condition and response to treatment.
Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
If you think you may have a serious medical problem, seek immediate medical attention.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Biotin (Septiva) is a water soluble B-complex vitamin needed for normal growth and development of skin and hair and maintenance of a healthy nervous system and bone marrow. It is used to prevent and treat Biotin (Septiva) deficiency associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. It is also used orally for hair loss, brittle nails, skin rash in infants (seborrheic dermatitis), diabetes, and mild depression.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Folic acid (Septiva) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.
Folic acid (Septiva) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Septiva) either through their diet or supplements to prevent infant spinal cord birth defects.
How to use Folic acid (Septiva)Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.
Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.
If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Methylcobalamin (Septiva) is an active form of vitamin B12, which is used to treat anemia as well as nerve damage with numbness, tingling, pain in various neurological disorders.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.To treat Hartnup disease (light sensitive skin rashes), inflammatory skin disease, vitamin deficiency, anxiety and Alzheimer’s disease (disorder that causes mental confusion and forgetfulness). It is also used in combination with intravenous Niacinamide (Septiva) therapy for cancer.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsDietary supplement
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsPyridoxine hydrochloride (Septiva) deficiency: Treatment and prevention of Pyridoxine hydrochloride (Septiva) (vitamin B) deficiency.
Off Label UsesEthylene glycol poisoning
The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride (Septiva) as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride (Septiva) in this condition.
Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride (Septiva) is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsTreatment of Thiamine hydrochloride (Septiva) deficiency (including Thiamine hydrochloride (Septiva) deficiency in pregnancy associated with neuropathy), beriberi (dry or wet variety), Wernicke encephalopathy, infantile beriberi with acute collapse, cardiovascular disease due to Thiamine hydrochloride (Septiva) deficiency, or when giving IV dextrose to individuals with marginal Thiamine hydrochloride (Septiva) status to avoid precipitation of heart failure; dietary supplement.
Off Label UsesAlcohol withdrawal syndrome (adjunct)
Data from a limited number of patients studied suggest that Thiamine hydrochloride (Septiva) may be beneficial as an adjunct in the management of alcohol withdrawal syndrome to prevent Wernicke encephalopathy.
a. Use only in a suitable ISO Class 5 work area such as a laminar flow hood (or an equivalent clean air compounding area)
b. Penetrate each PBP vial closure only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. Given that pressure may develop within the vial during storage, excercise caution when withdrawing contents from the vial.
c. Once the closure system has been penetrated, complete all dispensing from the PBP vial within 4 hours. Each dose must be used immediately. Discard unused portion.
d. Prior to administration, Ascorbic acid (Septiva) must be diluted in a suitable infusion solution and the final solution for infusion must be isotonic (undiluted the osmolarity of Ascorbic acid (Septiva) is approximately 5,900 mOsmol/L). Prior to preparing the admixture for infusion, calculate the osmolarity of the intended admixture for infusion. Add one daily dose of Ascorbic acid (Septiva) directly to an appropriate volume of a suitable infusion solution (e.g., 5% Dextrose Injection, Sterile Water for Injection) and add appropriate solutes, as necessary, to make final solution isotonic. Sterile Water for Injection is highly hypotonic; adjust solute content, as necessary, to make thet final infusion solution isotonic prior to injection. Do not mix Ascorbic acid (Septiva) with solutions containing elemental compounds that can be reduced (e.g., copper). The concentration of Ascorbic acid (Septiva) in the final, admixture solution for infusion is to be the range of 1 to 25 mg of Ascorbic acid (Septiva) per mL. For example, for the largest recommended dose:
Add 200 mg of Ascorbic acid (Septiva) (equivalent to 0.4 mL of Ascorbic acid (Septiva)) to 7.5 mL of Sterile Water for Injection to produce an infusion solution having an approximate osmolarity of 290 mOsmol/L. In this specific example, addition of solute is NOT necessary because the solution is isotonic.
e. Prepare the recommended dose based on the patient population [ see Dosage and Administration (2.2), (2.3)].
f. Visually inspect for particulate matter and discoloration prior to administration (the diluted Ascorbic acid (Septiva) solution should appear colorless to pale yellow).
g. Immediately administer the admixture for infusion as a slow intravenous infusion [ see Recommended Dosage, (2.2)]
Recommended Dosage
Table 1 provides recommended doses of Ascorbic acid (Septiva) based on patient population and infusion rates of diluted Ascorbic acid (Septiva) solution.
The recommended maximum duration of daily treatment with Ascorbic acid (Septiva) is seven days. If no improvement in scorbutic symptoms is observed after one week of treatment, retreat until resolution of scorbutic symptoms is observed.
Repeat dosing is not recommended in pediatric patients less than 11 years of age.
Dosage Reductions in Specific Populations
Women who are pregnant or lactating and patients with glucose-6-dehydrogenase deficiency should not exceed the U.S. Recommended Dietary Allowance (RDA) or daily Adequate Intake (AI) level for Ascorbic acid (Septiva) for their age group and condition [ see Warnings and Precautions (5.2) and Use in Specific Populations (8.1, 8.2)].
Dosage FormsExcipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral:Meribin: 5 mg
Capsule,
Oral [preservative free]:Biotin (Septiva) Extra Strength: 10 mg [gluten free; contains soybean lecithin, soybean oil]
Generic: 5000 mcg
Tablet,
Oral:Generic: 1000 mcg, 5 mg, 10 mg
Tablet,
Oral [preservative free]:Generic: 300 mcg [DSC], 1000 mcg
Dosing: Adult
Dietary supplementation (OTC labeling):
Oral: UsualDosage: One tablet or capsule daily; also see specific product labeling
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents:
Oral: 5 to 20 mgUsual Adult Dose for Megaloblastic Anemia1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.
Usual Adult Dose for Folic acid (Septiva) Deficiency
400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Folic acid (Septiva) Deficiency
Infant:
0.1 mg orally, intramuscularly, subcutaneously or IV once a day.
Child:
Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.
4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Vitamin/Mineral Supplementation
Recommended daily allowance (RDA):
Premature neonates: 50 mcg/day (15 mcg/kg/day).
Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.
Children:
1 to 3 years: 150 mcg/day.
4 to 8 years: 200 mcg/day.
9 to 13 years: 300 mcg/day.
14 years and older: 400 mcg/day.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.
Dialysis
Folic acid (Septiva) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.
Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.
Other Comments
The recommended daily allowance of Folic acid (Septiva) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.
There is a potential danger in administering Folic acid (Septiva) to patients with undiagnosed anemia, since Folic acid (Septiva) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.
Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.
Tablet: Adults: Usual Daily Dose: 3 tabs, equivalent to a total of 1500 mcg of mecobalamin, administered orally in 3 divided doses. The dose should be adjusted according to age of patient and severity of symptoms.
Injection: Peripheral Neuropathies: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. The dosage should be adjusted according to age of patient and severity of symptoms.
Megaloblastic Anemia: The usual adult dosage is 1 amp, equivalent to 500 mcg of mecobalamin administered IM or IV 3 times a week. After approximately 2 months of medication, the dose should be reduced to a single administration of 1 amp at 1- to 3-month intervals for maintenance therapy.
Applies to the following strengths: 100 mg; 500 mg
Usual Adult Dose for:
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide (Septiva) has toxic potential at adult doses in excess of 3 g/day.
Niacinamide (Septiva) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Usual Adult Dose for Pemphigus
Recommended Daily Allowances (RDA):
Males: 19 mg orally each day
Females: 13 mg orally each day
Initial dose: 100 mg orally 3 times a day, with or after meals
Maintenance dose: 100 to 500 mg orally up to 3 times a day, with or after meals
Niacinamide (Septiva) has toxic potential at adult doses in excess of 3 g/day.
Niacinamide (Septiva) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for adults contain 40 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients 11 years and older requiring parenteral vitamins.
Usual Pediatric Dose for Niacin Deficiency
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide (Septiva) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Usual Pediatric Dose for Pemphigus
Recommended Daily Allowances (RDA):
0 to 6 months: 5 mg orally each day
6 months to 1 year: 6 mg orally each day
1 to 3 years: 9 mg orally each day
4 to 6 years: 12 mg orally each day
7 to 10 years: 13 mg orally each day
Males:
11 to 14 years: 17 mg orally each day
15 to 18 years: 20 mg orally each day
19 to 50 years: 19 mg orally each day
Females:
11 to 50 years: 13 mg orally each day
Niacinamide (Septiva) may also be administered parenterally as a component of injectable multivitamin additives contained in parenteral nutrition products. All existing parenteral vitamin products for children contain 17 mg/vial, which is the dose recommended by the American Medical Association/Nutrition Advisory Group for patients under 11 years of age.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Because Niacinamide (Septiva) is primarily metabolized by the liver and because of the risk of hepatotoxicity, Niacinamide (Septiva) in not recommended in patients with liver dysfunction.
Dialysis
Data not available
Other Comments
Taking Niacinamide (Septiva) with food may reduce stomach upset.
Niacinamide (Septiva) should not be taken with hot drinks.
Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Niacinamide (Septiva)
Oral
Pantothenic acid (Septiva) deficiency
Adult: Recommended daily dose: 4-7 mg/day.
Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis:
Cycloserine: 100 to 300 mg/day orally in divided doses.
Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.
Oral contraceptives: 25 to 30 mg/day orally.Acute Intoxication:
Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.
Usual Adult Dose for Dietary Supplement:
Pyridoxine hydrochloride (Septiva) Deficiency:
10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.
Usual Adult Dose for Anemia:
Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.
If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride (Septiva) therapy, a different therapy should be considered.
Usual Adult Dose for Nausea/Vomiting:
Nausea and vomiting of Pregnancy:
25 mg orally every 8 hours.
Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :
Treatment: 10 to 50 mg/day.
Prophylaxis: 1 to 2 mg/kg/day
Acute Intoxication:
Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride (Septiva) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride (Septiva) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.
Usual Pediatric Dose for Dietary Supplement:
Pyridoxine hydrochloride (Septiva) Deficiency:
5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.
Usual Pediatric Dose for Seizures:
Pyridoxine hydrochloride (Septiva)-dependent seizures:
10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.
15ml 3-4 times/day or as directed by the physician.
See also:
What other drugs will affect Ascorbic acid (Septiva)?
In an application with barbiturates, primidone increases the excretion of Ascorbic acid (Septiva) in the urine.
With the simultaneous use of oral contraceptives reduces the concentration of Ascorbic acid (Septiva) in blood plasma.
In an application of Rhea Ascorbic acid (Septiva) with iron preparations Ascorbic acid (Septiva), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.
Ascorbic acid (Septiva) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.
With the simultaneous use of aspirin reduces the absorption of Ascorbic acid (Septiva) by about a third.
Rhea Ascorbic acid (Septiva) in an application with warfarin may decrease effects of warfarin.
With the simultaneous application of Ascorbic acid (Septiva) increases the excretion of iron in patients receiving deferoxamine. In the application of Ascorbic acid (Septiva) at a dose of 500 mg / day possibly left ventricular dysfunction.
In an application with tetracycline is increased excretion of Ascorbic acid (Septiva) in the urine.
There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Ascorbic acid (Septiva) 500 mg 2 times / day.
May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.
See also:
What other drugs will affect Biotin (Septiva)?
The anticonvulsants carbamazepine, phenytoin, Phenobarbital, and primidone may accelerate Biotin (Septiva) metabolism, leading to a reduction in available Biotin (Septiva). Chronic use of these drugs has been associated with decreased plasma concentrations of Biotin (Septiva).
The use of antibiotics may reduce the contribution of Biotin (Septiva) made by bacteria within the large intestine.
See also:
What other drugs will affect Folic acid (Septiva)?
Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Septiva). Folic acid (Septiva) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Septiva) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Septiva) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Septiva) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Septiva) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Septiva).
There are no known significant interactions.
See also:
What other drugs will affect Pyridoxine hydrochloride (Septiva)?
Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine
Increased need for Pyridoxine hydrochloride (Septiva).
Levodopa
Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride (Septiva).)
Phenytoin
Phenytoin serum levels may be decreased.
Incompatibility
Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).
Laboratory Test Interactions
May result in false-positive urobilinogen in the spot test using Ehrlich reagent.
See also:
What other drugs will affect Thiamine hydrochloride (Septiva)?
With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of paracetamol.
With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.
With the simultaneous use of anticholinergics may decrease absorption of paracetamol.
With the simultaneous use of oral contraceptives accelerated excretion of paracetamol from the body and may reduce its analgesic action.
With the simultaneous use with urological means reduced their effectiveness.
With the simultaneous use of activated charcoal reduced bioavailability of paracetamol.
When Thiamine hydrochloride (Septiva) applied simultaneously with diazepam may decrease excretion of diazepam.
There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with paracetamol. A case of severe toxic liver injury.
Described cases of toxic effects of paracetamol, while the use of isoniazid.
When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of paracetamol and phenobarbital.
In applying cholestyramine a period of less than 1 h after administration of paracetamol may decrease of its absorption.
At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.
With the simultaneous use of metoclopramide may increase absorption of paracetamol and its increased concentration in blood plasma.
When applied simultaneously with probenecid may decrease clearance of paracetamol, with rifampicin, sulfinpyrazone - may increase clearance of paracetamol due to increasing its metabolism in the liver.
At simultaneous application of Thiamine hydrochloride (Septiva) with ethinylestradiol increases absorption of paracetamol from the gut.
Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).
