The clinical picture observed during an overdose of cetyrizin was due to its influence on the central nervous system.
Symptoms : after a single intake of cetrizin at a dose of 50 mg, the following clinical picture was observed: confusion, diarrhea, dizziness, increased fatigue, headache, malaise, midriasis, skin itching, anxiety, sedative effect, drowsiness, stupor, tachycardia, tremor, urine delay.
Treatment: immediately after taking the drug, it is necessary to wash the stomach or induce vomiting. The appointment of activated carbon, symptomatic and supportive therapy are recommended. There is no specific antidote. Hemodialysis is ineffective.
When analyzing prospective data, more than 700 cases of pregnancy outcomes did not reveal cases of formation of malformations, embryonic and neonatal toxicity with a clear causal relationship with the use of cetyrizin.
Experimental studies on animals did not reveal any direct or indirect adverse effects of cetrizin on a developing fetus, pregnancy and postnatal development.
Adequate and strictly controlled clinical studies on the safety of the use of cetyrizin during pregnancy have not been conducted, so it should not be used during pregnancy.
FDA fruit action category - B .
Cetirisin stands out with breast milk - from 25 to 90% of its concentration in blood plasma, depending on the time after appointment. During breastfeeding, they are used after consultation with the doctor if the intended benefit for the mother exceeds the potential risk for the child.
Fertility. Available data on the effect on human fertility are limited, but no negative impact on fertility has been identified.
