Hypersensitivity to 1α-hydroxyvitamin D3, vitamin D or to any of the analogues and derivatives of Alfacalcidol (Ovasafe).
Alfacalcidol (Ovasafe) is contraindicated when there is a biochemical evidence of hypercalcaemia. Likewise, the drug is contraindicated when there is any evidence of vitamin D overdosage.
See also:
What is the most important information I should know about Biotin (Ovasafe)?
SINEQUAN is contraindicated in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.
SINEQUAN is contraindicated in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.
See also:
What is the most important information I should know about Cyanocobalamin (Ovasafe)?
You should not use this medication if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin (Ovasafe) can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.
To treat pernicious anemia, you will have to use this medication on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord.
Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Use all of your medications as directed.
Avoid eating or drinking hot foods or liquids within 1 hour before or after using the nasal form of this medication.
Tell your doctor if you develop nasal congestion, a cold, or allergies. The nasal spray may not work as well if you are congested.
Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.
See also:
What is the most important information I should know about Folic acid (Ovasafe)?
Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Ovasafe) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Ovasafe) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.
See also:
What is the most important information I should know about Magnesium (Ovasafe)?
Do NOT use Calcium Carbonate/Magnesium (Ovasafe) Carbonate if:
you are allergic to any ingredient in Calcium Carbonate/Magnesium (Ovasafe) Carbonate
you have an increased calcium level in your blood
Contact your doctor or health care provider right away if any of these apply to you.
See also:
What is the most important information I should know about Pyridoxine hydrochloride (Ovasafe)?
Contraindications for Vitamin B6 (Pyridoxine hydrochloride (Ovasafe))
Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.
See also:
What is the most important information I should know about Selenium (Ovasafe)?
Selenium (Ovasafe) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.
See also:
What is the most important information I should know about Zinc (Ovasafe)?
Hypersensitivity to any of the ingredients of Zinc (Ovasafe).
Anorexia, nausea, vomiting, diarrhoea, lassitude, polyuria, sweating, headache, thirst, vertigo, pruritus, rash, urticaria. Hypercalcaemia, hypercalciuria and ectopic calcification. In case of renal impairment, hyperphosphataemia. In hypercalcaemic dialysis patients, possibility of calcium influx from the dialysate should be considered.
See also:
What are the possible side effects of Biotin (Ovasafe)?
Adverse reactions associated with Biotin (Ovasafe) supplementation are rare in the medical literature; however, urticaria and gastrointestinal upset have been reported. As with any oral treatment, if patients experience any adverse reactions or side effects, they should inform their physicians immediately and discontinue use.
See also:
What are the possible side effects of Carbonyl iron (Ovasafe)?
Applies to Carbonyl iron (Ovasafe): suspension
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur while taking Carbonyl iron (Ovasafe) (the active ingredient contained in Carbonyl iron (Ovasafe))
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.
See also:
What are the possible side effects of Chromium picolinate (Ovasafe)?
Side effects following the proper administration of
therapeutic dose are not recorded.
See also:
What are the possible side effects of Cyanocobalamin (Ovasafe)?
The incidence of adverse experiences described in the Table below are based on data from a short-term clinical trial in vitamin B12 deficient patients in hematologic remission receiving Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe), USP) Gel for Intranasal Administration (N=24) and intramuscular vitamin B12 (N=25). In the pharmacokinetic study comparing Cyanocobalamin (Ovasafe) Nasal Spray and Cyanocobalamin (Ovasafe) Nasal Gel, the incidence of adverse events was similar.
The intensity of the reported adverse experiences following the administration of Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were generally mild. One patient reported severe headache following intramuscular dosing. Similarly, a few adverse experiences of moderate intensity were reported following intramuscular dosing (two headaches and rhinitis; one dyspepsia, arthritis, and dizziness), and dosing with Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe), USP) Gel for Intranasal Administration (one headache, infection, and paresthesia).
The majority of the reported adverse experiences following dosing with Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were judged to be intercurrent events. For the other reported adverse experiences, the relationship to study drug was judged as "possible" or "remote". Of the adverse experiences judged to be of "possible" relationship to the study drug, anxiety, incoordination, and nervousness were reported following intramuscular vitamin B12 and headache, nausea, and rhinitis were reported following dosing with Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe), USP) Gel for Intranasal Administration.
The following adverse reactions have been reported with parenteral vitamin B12:
Generalized: Anaphylactic shock and death.
Cardiovascular: Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.
Hematological: Polycythemia vera.
Gastrointestinal: Mild transient diarrhea.
Dermatological: Itching; transitory exanthema.
Miscellaneous: Feeling of swelling of the entire body.
See also:
What are the possible side effects of Folic acid (Ovasafe)?
Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Ovasafe).
Folic acid (Ovasafe) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Ovasafe) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Ovasafe) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Ovasafe) therapy.
In an uncontrolled study, orally administered Folic acid (Ovasafe) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Ovasafe) daily.
CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.
Abdominal bloating, Abdominal pain, Abnormality of blood, Allergy, Decreased blood pressure, Diarrhoea, Gout, Airway inflammation, Worsening of asthma
See also:
What are the possible side effects of Magnesium (Ovasafe)?
The adverse effects of parenterally administered Magnesium (Ovasafe) usually are the result of Magnesium (Ovasafe) intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Magnesium (Ovasafe) sulfate therapy for eclampsia has been reported.
Mild GI disturbances, bronchospasm, rash, itching, hypotension, HTN, nausea, vomiting, liver function impairment, rhinorrhea, stomatitis.
See also:
What are the possible side effects of Pyridoxine hydrochloride (Ovasafe)?
CNS
Neuropathy; unstable gait; drowsiness; somnolence.
EENT
Perioral numbness.
Miscellaneous
Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum Pyridoxine hydrochloride (Ovasafe) levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.
See also:
What are the possible side effects of Selenium (Ovasafe)?
Applies to Selenium (Ovasafe) sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension
As well as its needed effects, Selenium (Ovasafe) sulfide topical may cause unwanted side effects that require medical attention.
Severity: ModerateIf any of the following side effects occur while taking Selenium (Ovasafe) sulfide topical, check with your doctor or nurse as soon as possible:
Less common or rare:
Some Selenium (Ovasafe) sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
See also:
What are the possible side effects of Zinc (Ovasafe)?
Applies to Zinc (Ovasafe) sulfate: capsules, tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Ovasafe) sulfate (the active ingredient contained in Zinc (Ovasafe))
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.
Alfacalcidol (Ovasafe) is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. (Hypocalcemia; Osteodystrophy; secondary hyperparathyroidism;)
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Supplement for maintenance of health.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.skin disorders, Biotin (Ovasafe) deficiency, digestive disorders
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Helping to burn excess body fat
Helping to increase muscle mass in exercising individuals
Hypercholesterolemia
Chromium picolinate (Ovasafe)® is useful in diabetes mellitus because:
Chromium may prevent or delay the appearance of diabetes
In established diabetes, it could be taken with other hypoglycemic agents.
To improve the result of action of other hypoglycemics
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Cyanocobalamin (Ovasafe) Nasal Spray is indicated for the maintenance of normal hematologic status in pernicious anemia patients who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement.
Cyanocobalamin (Ovasafe) Nasal Spray is also indicated as a supplement for other vitamin B12 deficiencies, including:
I. Dietary deficiency of vitamin B12 occurring in strict vegetarians (Isolated vitamin B12 deficiency is very rare).
II. Malabsorption of vitamin B12 resulting from structural or functional damage to the stomach, where intrinsic factor is secreted, or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include HIV infection, AIDS, Crohn's disease, tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
III. Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency. Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
IV. Competition for vitamin B12 by intestinal parasites or bacteria. The fish tapeworm (Diphyllobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind loop syndrome may produce deficiency of vitamin B12 or folate.
V. Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption, use of a gluten-free diet in non-tropical sprue, or administration of antibiotics in tropical sprue. Such measures remove the need for long-term administration of vitamin B12.
Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation.
Cyanocobalamin (Ovasafe) Nasal Spray is not suitable for vitamin B12 absorption test (Schilling Test).
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Folic acid (Ovasafe) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Ovasafe) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Used for nutritional supplementation, also for treating dietary shortage or imbalance. (Acromegaly; Gigantism; Hyperammonemia; Hypophysectomy; Panhypopituitarism; Pituitary dwarfism; chromophobe adenoma; pituitary trauma; postsurgical craniopharyngioma; problems of growth and stature; urea cycle disorders;)
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Magnesium (Ovasafe) Sulfate Injection, USP is suitable for replacement therapy in Magnesium (Ovasafe) deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those observed in hypocalcemia. In such cases, the serum Magnesium (Ovasafe) (Mg++) level is usually below the lower limit of normal (1.5 to 2.5 mEq/liter) and the serum calcium (Ca++) level is normal (4.3 to 5.3 mEq/liter) or elevated.
In total parenteral nutrition (TPN), Magnesium (Ovasafe) sulfate may be added to the nutrient admixture to correct or prevent hypomagnesemia which can arise during the course of therapy.
Magnesium (Ovasafe) Sulfate Injection, USP is also indicated for the prevention and control of seizures (convulsions) in pre-eclampsia and eclampsia, respectively.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Adjuvant treatment in certain clinical conditions characterized by the presence of thick & viscous mucoid or mucopurulent secretions eg chronic bronchopulmonary disease (COPD, emphysema w/ bronchitis, chronic asthma bronchitis, bronchiectasis), acute bronchopulmonary disease (asthma w/ bronchial mucous plugging, bronchitis, bronchoneumonia, tracheobronchitis, bronchiolitis, pulmonary complication associated w/ surgery).
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.* Sideroblastic anaemia
* Treatment and prophylaxis of vitamin B6 deficiency states
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Oral
Selenium (Ovasafe) deficiency
Adult: 100-500 mcg of Selenium (Ovasafe) daily.
IntramuscularSelenium (Ovasafe) deficiency
Adult: 100-500 mcg of Selenium (Ovasafe) daily.
IntravenousSelenium (Ovasafe) deficiency
Adult: 100-500 mcg of Selenium (Ovasafe) daily.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Patients with deficiency of B-complex vitamins, vitamin C and Zinc (Ovasafe) or where supplementation of these vitamins and Zinc (Ovasafe) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.
Biotin (Ovasafe) is a form of vitamin B found in foods. Biotin (Ovasafe) helps the body break down fats, carbohydrates, and other substances.
Biotin (Ovasafe) has been used in alternative medicine as a likely effective aid in treating or preventing Biotin (Ovasafe) deficiency. Biotin (Ovasafe) deficiency can be caused by malnutrition, rapid weight loss, long-term tube feeding, and other medical conditions.
Biotin (Ovasafe) has also been used to treat seborrhea (skin rash) in babies. However, research has shown that Biotin (Ovasafe) may not be effective in treating this condition.
Other uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.
It is not certain whether Biotin (Ovasafe) is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Biotin (Ovasafe) should not be used in place of medication prescribed for you by your doctor.
Biotin (Ovasafe) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Biotin (Ovasafe) may also be used for purposes not listed in this product guide.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Carbonyl iron (Ovasafe) is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood.
Carbonyl iron (Ovasafe) is used as a dietary supplement, and to prevent and to treat iron deficiencies and iron deficiency anemia.
Carbonyl iron (Ovasafe) may also be used for purposes other than those listed in this medication guide.
Chromium is a mineral found in certain foods. The body needs only trace amounts of chromium, and deficiency of this mineral in humans is rare.
Chromium picolinate (Ovasafe) works together with insulin produced by the pancreas to metabolize carbohydrates.
Chromium picolinate (Ovasafe) has been used in alternative medicine to treat chromium deficiency, as an aid to controlling blood sugar in people with diabetes or prediabetes, to lower cholesterol, and as a weight-loss supplement.
Not all uses for Chromium picolinate (Ovasafe) have been approved by the FDA. Chromium picolinate (Ovasafe) should not be used in place of medication prescribed for you by your doctor.
Chromium picolinate (Ovasafe) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Chromium picolinate (Ovasafe) may also be used for purposes not listed in this product guide.
Cyanocobalamin (Ovasafe) nasal spray contains Cyanocobalamin (Ovasafe), a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.
Cyanocobalamin (Ovasafe) nasal spray is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions.
Cyanocobalamin (Ovasafe) nasal spray is usually given after treatment with an injection form of this medicine.
Cyanocobalamin (Ovasafe) may also be used for purposes not listed in this medication guide.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Ovasafe) (vitamin B 9) is necessary for strong blood.
Lack of Folic acid (Ovasafe) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Ovasafe) for you.
Some conditions may increase your need for Folic acid (Ovasafe). These include:
In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Ovasafe).
Increased need for Folic acid (Ovasafe) should be determined by your health care professional.
Some studies have found that Folic acid (Ovasafe) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).
Claims that Folic acid (Ovasafe) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.
Injectable Folic acid (Ovasafe) is given by or under the direction of your health care professional. Another form of Folic acid (Ovasafe) is available without a prescription.
Magnesium (Ovasafe) is used as a dietary supplement for individuals who are deficient in Magnesium (Ovasafe). Although a balanced diet usually supplies all the Magnesium (Ovasafe) a person needs, Magnesium (Ovasafe) supplements may be needed by patients who have lost Magnesium (Ovasafe) because of illness or treatment with certain medicines.
Lack of Magnesium (Ovasafe) may lead to irritability, muscle weakness, and irregular heartbeat.
Injectable Magnesium (Ovasafe) is given only by or under the supervision of a health care professional. Some oral Magnesium (Ovasafe) preparations are available only with a prescription. Others are available without a prescription.
Pyridoxine hydrochloride (Ovasafe) is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.
Pyridoxine hydrochloride (Ovasafe) is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine hydrochloride (Ovasafe) injection is also used to treat some types of seizure in babies.
Pyridoxine hydrochloride (Ovasafe) taken by mouth (oral) is available without a prescription. Injectable Pyridoxine hydrochloride (Ovasafe) must be given by a healthcare professional.
Pyridoxine hydrochloride (Ovasafe) may also be used for purposes not listed in this medication guide.
Selenium (Ovasafe) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Selenium (Ovasafe) is not produced in the body, but it is needed for proper thyroid and immune system function.
Selenium (Ovasafe) is used to treat or prevent Selenium (Ovasafe) deficiency.
Selenium (Ovasafe) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.
Not all uses for Selenium (Ovasafe) have been approved by the FDA. Selenium (Ovasafe) should not be used in place of medication prescribed for you by your doctor.
Selenium (Ovasafe) may also be used for purposes not listed in this product guide.
Zinc (Ovasafe) is a naturally occurring mineral. Zinc (Ovasafe) is important for growth and for the development and health of body tissues.
Zinc (Ovasafe) sulfate is used to treat and to prevent Zinc (Ovasafe) deficiency.
Zinc (Ovasafe) sulfate may also be used for purposes not listed in this medication guide.
Alfacalcidol (Ovasafe) is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. Alfacalcidol (Ovasafe) is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. Alfacalcidol (Ovasafe) is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. (PMID:17438884,17668216)
Astaxanthin (Ovasafe), an anti-oxidant, is used as a supplemental therapy for cancer, ocular diseases, sunburns, male infertility, cardiovascular diseases including stroke and hyperlipidemia.
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Cyanocobalamin (Ovasafe) (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin (Ovasafe)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin (Ovasafe) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of Cyanocobalamin (Ovasafe) are bacteria and archaea. Higher plants do not concentrate Cyanocobalamin (Ovasafe) from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin (Ovasafe) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Ovasafe) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
An essential amino acid that is physiologically active in the L-form. [PubChem]
Pyridoxine hydrochloride (Ovasafe) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride (Ovasafe) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Zinc (Ovasafe) Capsule: Each capsule contains Zinc (Ovasafe) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, Zinc (Ovasafe) 3 mg, vitamin B12 (coated) equivalent to Zinc (Ovasafe) 15 mcg, ascorbic acid 150 mg, Zinc (Ovasafe) 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.
Zinc (Ovasafe) Syrup: Each 5 mL contains Zinc (Ovasafe) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, Zinc (Ovasafe) 1 mg, Zinc (Ovasafe) 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.
Use Carbonyl iron (Ovasafe) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Carbonyl iron (Ovasafe).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use Chromium picolinate (Ovasafe) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Chromium picolinate (Ovasafe).
Use Cyanocobalamin (Ovasafe) (b12) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Cyanocobalamin (Ovasafe) (b12) spray.
Use Folic acid (Ovasafe) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Folic acid (Ovasafe).
Use Magnesium (Ovasafe) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Magnesium (Ovasafe).
Use Pyridoxine hydrochloride (Ovasafe) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (Ovasafe) (vitamin b6).
Use Selenium (Ovasafe) lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Selenium (Ovasafe) lotion.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Alfacalcidol (Ovasafe) is used to treat softening and deformity of the bones due to lack of calcium (rickets or osteomalacia), low levels of calcium in the blood of newborn babies and changes in bone caused by kidney failure (osteodystrophy).
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Biotin (Ovasafe) is a water soluble B-complex vitamin needed for normal growth and development of skin and hair and maintenance of a healthy nervous system and bone marrow. It is used to prevent and treat Biotin (Ovasafe) deficiency associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. It is also used orally for hair loss, brittle nails, skin rash in infants (seborrheic dermatitis), diabetes, and mild depression.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Iron supplements are takrn orally to treat and prevent anemia due to iron deficiency (lack of enough iron that affects development of red blood cells causing reduction in number of red blood cells in the body).Iron is also used in the form of iron dextran injection is used to treat iron deficiencies and iron deficiency anemia (low red blood cells) in severe deficiencies or when the patient cannot tolerate iron orally. Iron sucrose injection is used to treat iron deficiency anemia in people with kidney disease. It is usually given with another medication to promote the growth of red blood cells
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.How to use Cyanocobalamin (Ovasafe) nasalThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Folic acid (Ovasafe) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.
Folic acid (Ovasafe) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Ovasafe) either through their diet or supplements to prevent infant spinal cord birth defects.
How to use Folic acid (Ovasafe)Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.
Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.
If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.L-arginine (Ovasafe) is used for congestive heart failure, chest pain, high blood pressure, and coronary artery disease. L-arginine (Ovasafe) is also used for recurrent pain in the legs due to blocked arteries, decreased mental capacity in the elderly, erectile dysfunction, male infertility. L-arginine (Ovasafe) for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This medication is a mineral supplement used to prevent and treat low amounts of Magnesium (Ovasafe) in the blood. Magnesium (Ovasafe) is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of Magnesium (Ovasafe). However, certain situations cause your body to lose Magnesium (Ovasafe) faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes).
How to use Magnesium (Ovasafe) amino acid chelateTake this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
It is best to take Magnesium (Ovasafe) supplements with a meal to reduce stomach upset and diarrhea unless otherwise directed by the product instructions or your doctor.
Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew extended-release or delayed-release/enteric coated capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are using a liquid product, use a medication measuring device to carefully measure the dose. Do not use a household spoon because you may not get the correct dose. If you are using a suspension, shake the bottle well before each dose.
Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed on the product package or by your doctor. Too much Magnesium (Ovasafe) in the blood can cause serious side effects.
Tell your doctor if symptoms of low Magnesium (Ovasafe) blood levels (e.g., muscle cramps, tiredness, irritability, depression) persist or worsen. If you think you may have a serious medical problem, seek immediate medical attention.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsPyridoxine hydrochloride (Ovasafe) deficiency: Treatment and prevention of Pyridoxine hydrochloride (Ovasafe) (vitamin B) deficiency.
Off Label UsesEthylene glycol poisoning
The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride (Ovasafe) as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride (Ovasafe) in this condition.
Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride (Ovasafe) is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Selenium (Ovasafe) is used as a dietary supplement mainly in the treatment of Selenium (Ovasafe) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Selenium (Ovasafe) levels in body called Kashin-Beck Disease. Selenium (Ovasafe) supplements are also used in patients with HIV/ AIDS to maintain the adequate Selenium (Ovasafe) levels.
Initial Dose: Adults and Children >20 kg body weight: 1 mcg daily. Children <20 kg body weight: 0.05 mcg/kg/day. Neonates: 0.1 mcg/kg/day.
It is important to adjust dosage according to the biochemical responses and to avoid hypercalcaemia. Indices of response include levels of serum calcium, alkaline phosphatase, parathyroid hormone, urinary calcium excretion as well as radiographic and histological investigations. Patients with marked bone disease (other than those with renal failure) may tolerate higher doses without developing hypercalcaemia. However, failure of the serum calcium to rise promptly in osteomalacic patients does not necessarily mean that a higher dose is required, since calcium from increased intestinal calcium absorption may be incorporated into demineralized bone.
Most patients will respond to doses between 1 and 3 mcg daily.
The dose requirements generally decrease in patients with bone disease when there is biochemical or radiographic evidence of bone healing and in hypoparathyroid patients after normal serum calcium levels have been obtained. Maintenance doses are generally in the range of 0.25-2 mcg daily.
Alfacalcidol (Ovasafe) can be given as an IV injection following each hemodialysis. The injection should be administered into the return line from the hemodialysis machine at the end of each dialysis. The initial dose for adults is 1 mcg/dialysis. The maximum dose recommended is 6 mcg/dialysis and not more than 12 mcg/week.
Patients concurrently taking barbiturates or other anticonvulsants may need larger doses of Alfacalcidol (Ovasafe) to produce the desired effect.
Adult 1-4 licap once daily.
Dosage FormsExcipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule,
Oral:Meribin: 5 mg
Capsule,
Oral [preservative free]:Biotin (Ovasafe) Extra Strength: 10 mg [gluten free; contains soybean lecithin, soybean oil]
Generic: 5000 mcg
Tablet,
Oral:Generic: 1000 mcg, 5 mg, 10 mg
Tablet,
Oral [preservative free]:Generic: 300 mcg [DSC], 1000 mcg
Dosing: Adult
Dietary supplementation (OTC labeling):
Oral: UsualDosage: One tablet or capsule daily; also see specific product labeling
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents:
Oral: 5 to 20 mgUsual Adult Dose for Iron Deficiency Anemia:
50 mg orally three times a day.
Usual Pediatric Dose for Iron Deficiency Anemia:
Premature neonates:
2 to 4 mg Carbonyl iron (Ovasafe)/kg/day divided every 12 to 24 hours (maximum daily dose = 15 mg).
Infants and children <12 years:
Prophylaxis: 1 to 2 mg Carbonyl iron (Ovasafe)/kg/day (maximum 15 mg) in 1 to 2 divided doses.
Mild to moderate iron deficiency anemia:
3 mg Carbonyl iron (Ovasafe)/kg/day in 1 to 2 divided doses.
Severe iron deficiency anemia:
4 to 6 mg Carbonyl iron (Ovasafe)/kg/day in 3 divided doses.
Oral
Supplement for Type 1 and 2 diabetes
Adult: 200-1000 mcg daily.
The recommended initial dose of Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal Spray is one spray (500 mcg) administered in ONE nostril once weekly. Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal Spray should be administered at least one hour before or one hour after ingestion of hot foods or liquids. Periodic monitoring of serum B levels should be obtained to establish adequacy of therapy.
Priming (Activation) of PumpBefore the first dose and administration, the pump must be primed. Remove the clear plastic cover and the plastic safety clip from the pump. To prime the pump, place nozzle between the first and second finger with the thumb on the bottom of the bottle. Pump the unit firmly and quickly until the first appearance of spray. Then prime the pump an additional 2 times. Now the nasal spray is ready for use. The unit must be re-primed before each dose. Prime the pump once immediately before each administration of doses 2 through 8.
How suppliedCyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal Spray is available as a spray in 3 mL glass bottles containing 2.3 mL of solution. It is available in a dosage strength of 500 mcg per actuation (0.1 mL/actuation). A screw-on actuator is provided. This actuator, following priming, will deliver 0.1 mL of the spray. Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal Spray is provided in a carton containing a nasal spray actuator with dust cover, a bottle of nasal spray solution, and a package insert. One bottle will deliver 8 doses (NDC 67871-773-35).
Pharmacist Assembly Instructions For Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal SprayThe pharmacist should assemble the Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)) Nasal Spray unit prior to dispensing to the patient, according to the following instructions:
Mfd. for QOL Medical, LLC
Kirland, WA 98033, USA
1.866.469.3773
www.Cyanocobalamin (Ovasafe) (Cyanocobalamin (Ovasafe)).com
3078 Rev. 02/06
FDA rev date: 9/15/2006
Usual Adult Dose for Megaloblastic Anemia1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.
Usual Adult Dose for Folic acid (Ovasafe) Deficiency
400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Folic acid (Ovasafe) Deficiency
Infant:
0.1 mg orally, intramuscularly, subcutaneously or IV once a day.
Child:
Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.
4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Vitamin/Mineral Supplementation
Recommended daily allowance (RDA):
Premature neonates: 50 mcg/day (15 mcg/kg/day).
Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.
Children:
1 to 3 years: 150 mcg/day.
4 to 8 years: 200 mcg/day.
9 to 13 years: 300 mcg/day.
14 years and older: 400 mcg/day.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.
Dialysis
Folic acid (Ovasafe) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.
Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.
Other Comments
The recommended daily allowance of Folic acid (Ovasafe) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.
There is a potential danger in administering Folic acid (Ovasafe) to patients with undiagnosed anemia, since Folic acid (Ovasafe) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.
Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.
Dosage depends on the severity of the catabolic state & amino acid requirement. Daily dose: 10-20ml/kg body wt equiv to 1-2g amino acids/kg body wt. Maximum daily dosage not >2g amino acids/kg body wt.
Usual Adult Dose for Hypomagnesemia500 to 1000 mg Magnesium (Ovasafe) gluconate (27 to 54 mg elemental Magnesium (Ovasafe)) orally 3 times a day.
Usual Adult Dose for Dietary Supplement
500 to 1000 mg Magnesium (Ovasafe) gluconate (27 to 54 mg elemental Magnesium (Ovasafe)) orally once a day.
Usual Pediatric Dose for Hypomagnesemia
10 to 20 mg/kg of elemental Magnesium (Ovasafe) per dose orally 4 times a day. Use Magnesium (Ovasafe) gluconate oral liquid preparations for more accurate measurement of dose.
Renal Dose Adjustments
Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Magnesium (Ovasafe) salts are generally contraindicated in patients with severe renal dysfunction.
Liver Dose Adjustments
Data not available
Dose Adjustments
May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Magnesium (Ovasafe)) in order to achieve a normal serum Magnesium (Ovasafe) level. Daily doses > 1,000 mg (54 mg elemental Magnesium (Ovasafe)) should be given in 2 to 3 divided doses.
Precautions
Because Magnesium (Ovasafe) is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.
Dialysis
Data not available; however, use of Magnesium (Ovasafe) salts is generally contraindicated in renal failure.
Other Comments
Magnesium (Ovasafe) supplements are often used with "low normal" serum Magnesium (Ovasafe) levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).
Adult Acute treatment N-acetylcysteine (Ovasafe) 1 tab 3 times daily for 5-10 days. N-acetylcysteine (Ovasafe) Forte 1 tab daily for 5-10 days. Chronic treatment N-acetylcysteine (Ovasafe) 1 tab 3 times daily for 1-2 mth. N-acetylcysteine (Ovasafe) Forte 1 tab daily for 1-2 mth.
Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis:
Cycloserine: 100 to 300 mg/day orally in divided doses.
Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.
Oral contraceptives: 25 to 30 mg/day orally.Acute Intoxication:
Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.
Usual Adult Dose for Dietary Supplement:
Pyridoxine hydrochloride (Ovasafe) Deficiency:
10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.
Usual Adult Dose for Anemia:
Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.
If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride (Ovasafe) therapy, a different therapy should be considered.
Usual Adult Dose for Nausea/Vomiting:
Nausea and vomiting of Pregnancy:
25 mg orally every 8 hours.
Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :
Treatment: 10 to 50 mg/day.
Prophylaxis: 1 to 2 mg/kg/day
Acute Intoxication:
Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride (Ovasafe) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride (Ovasafe) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.
Usual Pediatric Dose for Dietary Supplement:
Pyridoxine hydrochloride (Ovasafe) Deficiency:
5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.
Usual Pediatric Dose for Seizures:
Pyridoxine hydrochloride (Ovasafe)-dependent seizures:
10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.
Selenium (Ovasafe) Injection provides 40 mcg Selenium (Ovasafe)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Selenium (Ovasafe)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.
In adults, Selenium (Ovasafe) deficiency states resulting from long-term TPN support, Selenium (Ovasafe) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.
Aseptic addition of Selenium (Ovasafe) Injection to the TPN solution under laminar flow hood is recommended. Selenium (Ovasafe) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium (Ovasafe) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium (Ovasafe) is approximately 10 to 37 mcg/100 mL.
Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.
Zinc (Ovasafe) 1 mg/mL (Zinc (Ovasafe) Chloride Injection, USP) contains 1 mg Zinc (Ovasafe)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Ovasafe)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Ovasafe)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Ovasafe)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Ovasafe)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Ovasafe) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Ovasafe).
For full term infants and children up to 5 years of age, 100 mcg Zinc (Ovasafe)/kg/day
(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Ovasafe)/kg/day (0.3 mL/kg/day) is suggested.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
How suppliedZinc (Ovasafe) 1 mg/mL (Zinc (Ovasafe) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).
Store at 20 to 25°C (68 to 77°F).
HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004
Patients taking barbiturates or anticonvulsants may require larger doses of Alfacalcidol (Ovasafe) to produce the desired effect.
Incompatibilities: Alfacalcidol (Ovasafe) should not be used concomitantly with other vitamin D products or derivates.
See also:
What other drugs will affect Biotin (Ovasafe)?
The anticonvulsants carbamazepine, phenytoin, Phenobarbital, and primidone may accelerate Biotin (Ovasafe) metabolism, leading to a reduction in available Biotin (Ovasafe). Chronic use of these drugs has been associated with decreased plasma concentrations of Biotin (Ovasafe).
The use of antibiotics may reduce the contribution of Biotin (Ovasafe) made by bacteria within the large intestine.
See also:
What other drugs will affect Cyanocobalamin (Ovasafe)?
The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.
To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
Some products that may interact with this drug include: drugs that affect the bone marrow (such as chloramphenicol), vitamins/supplements that contain intrinsic factor.
Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers including cimetidine/famotidine, proton pump inhibitors such as omeprazole/lansoprazole).
Vitamin B12 is an ingredient found in many combination vitamin and nutritional products. Tell your doctor or pharmacist if you are taking other products that contain Cyanocobalamin (Ovasafe), vitamin B12, or hydroxocobalamin.
Cyanocobalamin (Ovasafe) may interfere with certain laboratory tests (including intrinsic factor, blood tests for other types of anemia), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Certain drugs may interfere with laboratory tests for vitamin B12 levels, possibly causing false results. Tell laboratory personnel and all your doctors if you take any of the following: antibiotics (such as amoxicillin, erythromycin), methotrexate, pyrimethamine.
This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
See also:
What other drugs will affect Folic acid (Ovasafe)?
Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Ovasafe). Folic acid (Ovasafe) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Ovasafe) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Ovasafe) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Ovasafe) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Ovasafe) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Ovasafe).
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What other drugs will affect Magnesium (Ovasafe)?
Magnesium (Ovasafe): May increase the serum concentration of Magnesium (Ovasafe) Salts. Consider therapy modification
Alpha-Lipoic Acid: Magnesium (Ovasafe) Salts may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Magnesium (Ovasafe) Salts. Consider therapy modification
Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination
Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification
Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification
Calcitriol (Systemic): May increase the serum concentration of Magnesium (Ovasafe) Salts. Management: Consider using a non-Magnesium (Ovasafe)-containing antacid or phosphate-binding product in patients also receiving calcitriol. If Magnesium (Ovasafe)-containing products must be used with calcitriol, serum Magnesium (Ovasafe) concentrations should be monitored closely. Consider therapy modification
Calcium Channel Blockers: May enhance the adverse/toxic effect of Magnesium (Ovasafe) Salts. Magnesium (Ovasafe) Salts may enhance the hypotensive effect of Calcium Channel Blockers. Monitor therapy
Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification
Dolutegravir: Magnesium (Ovasafe) Salts may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Magnesium (Ovasafe) salts. Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Magnesium (Ovasafe) salts. Consider therapy modification
Doxercalciferol: May enhance the hypermagnesemic effect of Magnesium (Ovasafe) Salts. Management: Consider using a non-Magnesium (Ovasafe)-containing antacid or phosphate-binding product in patients also receiving doxercalciferol. If Magnesium (Ovasafe)-containing products must be used with doxercalciferol, serum Magnesium (Ovasafe) concentrations should be monitored closely. Consider therapy modification
Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification
Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification
Gabapentin: Magnesium (Ovasafe) Salts may enhance the CNS depressant effect of Gabapentin. Specifically, high dose intravenous/epidural Magnesium (Ovasafe) sulfate may enhance the CNS depressant effects of gabapentin. Magnesium (Ovasafe) Salts may decrease the serum concentration of Gabapentin. Management: Administer gabapentin at least 2 hours after use of a Magnesium (Ovasafe)-containing antacid. Monitor patients closely for evidence of reduced response to gabapentin therapy. Monitor for CNS depression if high dose IV/epidural Magnesium (Ovasafe) sulfate is used. Consider therapy modification
Levothyroxine: Magnesium (Ovasafe) Salts may decrease the serum concentration of Levothyroxine. Management: Separate administration of oral levothyroxine and oral Magnesium (Ovasafe) salts by at least 4 hours. Consider therapy modification
Multivitamins/Fluoride (with ADE): Magnesium (Ovasafe) Salts may decrease the serum concentration of Multivitamins/Fluoride (with ADE). Specifically, Magnesium (Ovasafe) salts may decrease fluoride absorption. Management: To avoid this potential interaction separate the administration of Magnesium (Ovasafe) salts from administration of a fluoride-containing product by at least 1 hour. Consider therapy modification
Mycophenolate: Magnesium (Ovasafe) Salts may decrease the serum concentration of Mycophenolate. Management: Separate doses of mycophenolate and oral Magnesium (Ovasafe) salts. Monitor for reduced effects of mycophenolate if taken concomitant with oral Magnesium (Ovasafe) salts. Consider therapy modification
Neuromuscular-Blocking Agents: Magnesium (Ovasafe) Salts may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification
Phosphate Supplements: Magnesium (Ovasafe) Salts may decrease the serum concentration of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral Magnesium (Ovasafe) salt as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Consider therapy modification
Quinolones: Magnesium (Ovasafe) Salts may decrease the serum concentration of Quinolones. Management: Administer oral quinolones several hours before (4 h for moxi/pe/spar-, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome/pe-, 3 h for gemi-, and 2 h for levo-, nor-, or ofloxacin or nalidixic acid) oral Magnesium (Ovasafe) salts. Exceptions: LevoFLOXacin (Oral Inhalation). Consider therapy modification
Raltegravir: Magnesium (Ovasafe) Salts may decrease the serum concentration of Raltegravir. Management: Avoid the use of oral / enteral Magnesium (Ovasafe) salts with raltegravir. No dose separation schedule has been established that adequately reduces the magnitude of interaction. Avoid combination
Tetracyclines: Magnesium (Ovasafe) Salts may decrease the absorption of Tetracyclines. Only applicable to oral preparations of each agent. Management: Avoid coadministration of oral Magnesium (Ovasafe) salts and oral tetracyclines. If coadministration cannot be avoided, administer oral Magnesium (Ovasafe) at least 2 hours before, or 4 hours after, oral tetracyclines. Monitor for decreased tetracycline therapeutic effects. Exceptions: Eravacycline. Consider therapy modification
Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification
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What other drugs will affect Pyridoxine hydrochloride (Ovasafe)?
Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine
Increased need for Pyridoxine hydrochloride (Ovasafe).
Levodopa
Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride (Ovasafe).)
Phenytoin
Phenytoin serum levels may be decreased.
Incompatibility
Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).
Laboratory Test Interactions
May result in false-positive urobilinogen in the spot test using Ehrlich reagent.
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What other drugs will affect Selenium (Ovasafe)?
Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination
Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification
Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification
Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification
Dolutegravir: Selenium (Ovasafe) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Selenium (Ovasafe). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Selenium (Ovasafe). Consider therapy modification
Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification
Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification
PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification
Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification
Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification
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What other drugs will affect Zinc (Ovasafe)?
Zinc (Ovasafe) reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for Zinc (Ovasafe).
Absorption of Zinc (Ovasafe) from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H2-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.
Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia.
Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and Zinc (Ovasafe) antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; Zinc (Ovasafe) may decrease serum-phenytoin concentrations.
There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.
Ascorbic acid may increase the absorption of iron-deficiency states.
Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.
The absorption of Zinc (Ovasafe) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Ovasafe) supplements reduce the absorption of copper, ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.
