Hypersensitivity. Estrogen-dependent tumors, endometriosis, vag hemorrhaging of unknown origin, females who are not yet sexually mature
contraindicated in patients with hypersensitivity to any of its components.
See also:
What is the most important information I should know about Pyridoxine hydrochloride?
Contraindications for Vitamin B6 (Pyridoxine hydrochloride)
Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.
See also:
What is the most important information I should know about Riboflavin?
None well documented.
do not use in the treatment of leber disease or tobaco intoxication.
Local irritation (mild stinging or burning).
Allergic sensitization has been reported rarely following oral and parenteral administration of Folic Acid.
At recommended doses, nicotinamide is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of nicotinamide or zinc at doses greater than the recommended dose of nicotinamide
Nicotinamide: Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.
See also:
What are the possible side effects of Pyridoxine hydrochloride?
CNS
Neuropathy; unstable gait; drowsiness; somnolence.
EENT
Perioral numbness.
Miscellaneous
Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum folic acid levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.
See also:
What are the possible side effects of Riboflavin?
Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)
anaphylactic reactions rarely, severe cases can cause death, urine yellow colouration,peripheral neuropathy in case of prolonged useage, arrythmias,
Diarrhea of any etiology infantile, weaning, and neonatal diarrhea along with any antidiarrhoeal, IBD/IBS, UTI
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.To avoid and correct vitamin deficiency, which may
result from an imbalanced or special diet, impaired
absorption, anorexia, slimming, pathological intestinal
flora, debilitating disease or therapy with drugs acting
as vitamin antagonists.
Nicotinamide syrup meets the increased vitamin requirements
during periods of intensive growth, and as a dietary
supplement in premature and newborn infants.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.* Sideroblastic anaemia
* Treatment and prophylaxis of vitamin B6 deficiency states
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Oral
Prophylaxis of riboflavin deficiency
Adult: 1-2 mg daily.
Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.
OralRiboflavin deficiency
Adult: Up to 30 mg daily in divided doses.
Child: 3-10 mg daily.
Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.
OralMicrocytic anaemia
Adult: Associated with splenomegaly and glutathione reductase deficiency: 10 mg daily for 10 days.
Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.treatment of vitamin B deficiencies and prevention of it.
Pyridoxine hydrochloride is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.
Pyridoxine hydrochloride is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine hydrochloride injection is also used to treat some types of seizure in babies.
Pyridoxine hydrochloride taken by mouth (oral) is available without a prescription. Injectable Pyridoxine hydrochloride must be given by a healthcare professional.
Pyridoxine hydrochloride may also be used for purposes not listed in this medication guide.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Riboflavin (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. It also makes it possible for oxygen to be used by your body.
Lack of riboflavin may lead to itching and burning eyes, sensitivity of eyes to light, sore tongue, itching and peeling skin on the nose and scrotum, and sores in the mouth. Your doctor may treat this condition by prescribing riboflavin for you.
Some conditions may increase your need for riboflavin. These include:
In addition, riboflavin may be given to infants with high blood levels of bilirubin (hyperbilirubinemia).
Increased need for riboflavin should be determined by your health care professional.
Claims that riboflavin is effective for treatment of acne, some kinds of anemia (weak blood), migraine headaches, and muscle cramps have not been proven.
Oral forms of riboflavin are available without a prescription.An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]
Pyridoxine hydrochloride is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Use Pyridoxine hydrochloride (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (vitamin b6).
A surgeon or other healthcare provider will give you this medicine as part of your corneal collagen crosslinking procedure.
You will be given numbing eyedrops to prepare you for the procedure. You may also be given a sedative or anesthesia to help you relax. Although you will most likely be awake during the procedure, you should feel little or no discomfort. A special device will be placed around your eyelids to keep them open during the procedure.
Your eye surgeon will place riboflavin ophthalmic drops into your eyes about every 2 minutes during the procedure.
After the procedure, the surgeon will place a contact lens on the treated eye to protect it for a short time.
Call your doctor right away if the contact lens falls out or feels like it is out of place inside your eye.
You may also need to use antibiotic or steroid eyedrops to prevent infection and reduce swelling after your procedure. Carefully follow all after-care instructions and do not miss any follow-up appointments.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Intestinal support, healthy lipid metabolism.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Nicotinamide is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsPyridoxine hydrochloride deficiency: Treatment and prevention of Pyridoxine hydrochloride (vitamin B) deficiency.
Off Label UsesEthylene glycol poisoning
The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride in this condition.
Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Riboflavin (riboflavin) supplementation is used to prevent and treat riboflavin deficiency. Riboflavin may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Riboflavin is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.
1-2 tabs bid or as directed by the physician.
Oral
Treatment and prophylaxis of nicotinic acid deficiency
Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.
Topical/CutaneousMild to moderate inflammatory acne
Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.
Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis:
Cycloserine: 100 to 300 mg/day orally in divided doses.
Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.
Oral contraceptives: 25 to 30 mg/day orally.Acute Intoxication:
Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.
Usual Adult Dose for Dietary Supplement:
Pyridoxine hydrochloride Deficiency:
10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.
Usual Adult Dose for Anemia:
Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.
If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride therapy, a different therapy should be considered.
Usual Adult Dose for Nausea/Vomiting:
Nausea and vomiting of Pregnancy:
25 mg orally every 8 hours.
Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :
Treatment: 10 to 50 mg/day.
Prophylaxis: 1 to 2 mg/kg/day
Acute Intoxication:
Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.
Usual Pediatric Dose for Dietary Supplement:
Pyridoxine hydrochloride Deficiency:
5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.
Usual Pediatric Dose for Seizures:
Pyridoxine hydrochloride-dependent seizures:
10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.
Dosage FormsExcipient information presented when available (limited, particularly for generics); consult specific product labeling.
Capsule,
Oral:B-2-400: 400 mg
Generic: 50 mg
Tablet,
Oral:Generic: 25 mg, 50 mg, 100 mg
Dosing: Adult
Dietary supplement:
Oral: 100 mg once or twice dailyPrevention of migraine headache (off-label use):
Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998)Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of riboflavin supplementation in pediatric patients; the use of a single-ingredient riboflavin product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient riboflavin supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.
Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents:
Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (riboflavin) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).
Lactobacillus acidophilus is sensitive to anti-infective agents.
Nicotinamide: The clearance of primidone and carbamazepine may be reduced with the concomitant use of nicotinamide.
Zinc Oxide: The absorption of quinolones or tetracycline may be decreased with the concomitant use of zinc.
Cupric Oxide: Concomitant use of penicillamine and copper can cause decreased absorption of both substances.
See also:
What other drugs will affect Pyridoxine hydrochloride?
Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine
Increased need for Pyridoxine hydrochloride.
Levodopa
Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride.)
Phenytoin
Phenytoin serum levels may be decreased.
Incompatibility
Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).
Laboratory Test Interactions
May result in false-positive urobilinogen in the spot test using Ehrlich reagent.
See also:
What other drugs will affect Riboflavin?
Interactions for Riboflavin (Riboflavin)
Alcohol - impairs the intestinal absorption of riboflavi
Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications
Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.
none known
