In the absence of any reports of the accidental ingestion of Hirudoid, no specific advice is available. General supportive measures may be appropriate.
5 years.
Not to be used on large areas of skin, broken skin, sensitive areas of skin or mucous membranes. Not to be used in individuals with a known sensitivity to any active or inactive component of the formulation. Not to be used in children under 5 years of age.
None.
Anhydrous eucerine
Emulsifying cetostearyl alcohol type A
Glycerol
Isopropyl alcohol
Methyl parahydroxybenzoate (E218)
Myristyl alcohol
Potassium hydroxide
Propyl parahydroxybenzoate (E216)
Purified water
Stearic acid
Thymol
Topical cream.
None known.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard
None stated.
Hirudoid is indicated for the treatment of superficial thrombophlebitis and the soothing relief of superficial bruising and haematoma.
Heparinoid is recognised as having: a weak inhibitory effect on PGE2 synthesis and an indirect effect on LTB4 production (based on in vitro studies), anti-coagulant activity (as a heparinoid), thrombolytic activity (through potentiation of urokinase activity), anti-exudatory activity (through inhibition of hyaluronidase).
Radiochemical studies of absorption following cutaneous application of heparinoid (mucopolysaccharide polysulphate) have shown that between 0.3 and 4% of the mucopolysaccharide administered is absorbed by various tissues (other than the treated area) within the first 8 hours. Typically between 1.7% and 4.6% will be absorbed within 2 to 4 days. Animal studies have also shown that mucopolysaccharide is bound intracellularly within the subcutis. Peak serum concentrations following cutaneous application are below the threshold of physiological relevance for coagulation. Mucopolysaccharide is excreted in the urine partly unchanged and partly as depolymerized, shorter chain length molecules.
10/04/2015
Hirudoid Cream
Genus Pharmaceuticals Limited
T/A Genus Pharmaceuticals
Linthwaite,
Huddersfield,
HD7 5QH, UK
Store below 25°C.
Lacquered aluminium tubes 14, 40, 50g.
PL 06831/0175
Heparinoid 0.3% wlw (Equivalent to 25 000 Units per 100 g cream).
For external use only. If symptoms persist or worsen, seek medical advice. Do not exceed the stated dose.
None.
Adults, the elderly and children over 5 years of age:
Two to six inches (5-15 cm) to be applied up to four times daily to the affected area and gently massaged into the skin.
Not applicable.
02/02/2006
