See also:
What is the most important information I should know about Ferrous gluconate (Fertisure-F)?
Disturbances in iron utilization (lead anemia), Thalassemia.
Hypersensitivity or intolerance to iron and overloading of iron in the body.
Anemia not caused by iron deficiency.
See also:
What is the most important information I should know about Folic acid (Fertisure-F)?
Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Fertisure-F) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Fertisure-F) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.
Most Significant
Lactating Mother, Pregnancy, Prostatic Carcinoma, Selenium Toxicity, Wilson’s Disease
Possibly Significant
Vitamin K Deficiency Induced Hypoprothrombinemia
See also:
What is the most important information I should know about Pyridoxine hydrochloride (Fertisure-F)?
Contraindications for Vitamin B6 (Pyridoxine hydrochloride (Fertisure-F))
Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.
See also:
What is the most important information I should know about Selenium (Fertisure-F)?
Selenium (Fertisure-F) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.
Hypersensitivity to the components of the formula. History of allergy to the cobalamins (Vitamin B12 (Fertisure-F) and similar substances). Malignant tumors. By stimulating the growth of tissues, the Cobamamide could increase the high rate of cell multiplication. Sensitivity to cobalt. History of allergies to cobalamin (Vitamin B12 (Fertisure-F) and related substances).
- Malignant tumor: Due to the action of Vitamin B12 (Fertisure-F) on the growth of tissue cell multiplication rate high, the risk of exacerbation should be taken into account.
- Children under 6 years because of the dosage form
See also:
What is the most important information I should know about Zinc (Fertisure-F)?
Hypersensitivity to any of the ingredients of Zinc (Fertisure-F).
See also:
What are the possible side effects of Ferrous gluconate (Fertisure-F)?
Applies to Ferrous gluconate (Fertisure-F): capsules, tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur while taking Ferrous gluconate (Fertisure-F) (the active ingredient contained in Ferrous gluconate (Fertisure-F))
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.
See also:
What are the possible side effects of Folic acid (Fertisure-F)?
Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Fertisure-F).
Folic acid (Fertisure-F) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Fertisure-F) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Fertisure-F) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Fertisure-F) therapy.
In an uncontrolled study, orally administered Folic acid (Fertisure-F) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Fertisure-F) daily.
CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.
Abdominal bloating, Abdominal pain, Abnormality of blood, Allergy, Decreased blood pressure, Diarrhoea, Gout, Airway inflammation, Worsening of asthma
Rare:
Abdominal Pain with Cramps, Back Pain, Blurred Vision, Constipation, Diarrhea, Dizziness, Dysuria, Erectile Dysfunction, Fatigue, Headache Disorder, Hypertension, Libido Changes, Nausea, Urinary Retention
See also:
What are the possible side effects of Pyridoxine hydrochloride (Fertisure-F)?
CNS
Neuropathy; unstable gait; drowsiness; somnolence.
EENT
Perioral numbness.
Miscellaneous
Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum Pyridoxine hydrochloride (Fertisure-F) levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.
See also:
What are the possible side effects of Selenium (Fertisure-F)?
Applies to Selenium (Fertisure-F) sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension
As well as its needed effects, Selenium (Fertisure-F) sulfide topical may cause unwanted side effects that require medical attention.
Severity: ModerateIf any of the following side effects occur while taking Selenium (Fertisure-F) sulfide topical, check with your doctor or nurse as soon as possible:
Less common or rare:
Some Selenium (Fertisure-F) sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
More common:
See also:
What are the possible side effects of Vitamin B12 (Fertisure-F)?
Applies to cyanocobalamin: intramuscular solution
Other dosage forms:
As well as its needed effects, cyanocobalamin (the active ingredient contained in Vitamin B12 (Fertisure-F)) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking cyanocobalamin, check with your doctor or nurse immediately:
Incidence not known:
Some cyanocobalamin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:
Incidence not known:
See also:
What are the possible side effects of Zinc (Fertisure-F)?
Applies to Zinc (Fertisure-F) sulfate: capsules, tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Nausea; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Fertisure-F) sulfate (the active ingredient contained in Zinc (Fertisure-F))
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.
Dietary supplement which helps maintain stamina & as an antioxidant.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Oral
Iron-deficiency anaemia
Adult: Expressed in terms of elemental iron. Treatment: 60 mg bid up to 60 mg 4 times daily. Prevention: 60 mg daily.
Child: Expressed in terms of elemental iron. Treatment: Severe: 4-6 mg/kg/day in 3 divided doses; Mild to moderate: 3 mg/kg/day in 1-2 divided doses. Prevention: 1-2 mgkg/day.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Folic acid (Fertisure-F) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Fertisure-F) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Used for nutritional supplementation, also for treating dietary shortage or imbalance. (Acromegaly; Gigantism; Hyperammonemia; Hypophysectomy; Panhypopituitarism; Pituitary dwarfism; chromophobe adenoma; pituitary trauma; postsurgical craniopharyngioma; problems of growth and stature; urea cycle disorders;)
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.These compounds act mainly as normalizatoare of cellular metabolic process. ale fenomenelor oxidative si de imbatranire. Alterations mentioned processes underlying degenerative processes of cell aging and oxidative phenomena
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.* Sideroblastic anaemia
* Treatment and prophylaxis of vitamin B6 deficiency states
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Oral
Selenium (Fertisure-F) deficiency
Adult: 100-500 mcg of Selenium (Fertisure-F) daily.
IntramuscularSelenium (Fertisure-F) deficiency
Adult: 100-500 mcg of Selenium (Fertisure-F) daily.
IntravenousSelenium (Fertisure-F) deficiency
Adult: 100-500 mcg of Selenium (Fertisure-F) daily.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12 (Fertisure-F), occurring in strict vegetarians and in their breast-fed infants. (Isolated Vitamin B12 (Fertisure-F) deficiency is very rare).
Malabsorption of Vitamin B12 (Fertisure-F), resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates Vitamin B12 (Fertisure-F) absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than Vitamin B12 (Fertisure-F) deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces Vitamin B12 (Fertisure-F) deficiency.
Structural lesions leading to Vitamin B12 (Fertisure-F) deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 (Fertisure-F) by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of Vitamin B12 (Fertisure-F) and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 (Fertisure-F) or folate.
Inadequate utilization of Vitamin B12 (Fertisure-F). This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Patients with deficiency of B-complex vitamins, vitamin C and Zinc (Fertisure-F) or where supplementation of these vitamins and Zinc (Fertisure-F) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.
Ferrous gluconate (Fertisure-F) is a type of iron. You normally get iron from the foods you eat. In your body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.
Ferrous gluconate (Fertisure-F) is used to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body).
Ferrous gluconate (Fertisure-F) may also be used for purposes not listed in this medication guide.
Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Fertisure-F) (vitamin B 9) is necessary for strong blood.
Lack of Folic acid (Fertisure-F) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Fertisure-F) for you.
Some conditions may increase your need for Folic acid (Fertisure-F). These include:
In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Fertisure-F).
Increased need for Folic acid (Fertisure-F) should be determined by your health care professional.
Some studies have found that Folic acid (Fertisure-F) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).
Claims that Folic acid (Fertisure-F) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.
Injectable Folic acid (Fertisure-F) is given by or under the direction of your health care professional. Another form of Folic acid (Fertisure-F) is available without a prescription.
Pyridoxine hydrochloride (Fertisure-F) is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.
Pyridoxine hydrochloride (Fertisure-F) is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine hydrochloride (Fertisure-F) injection is also used to treat some types of seizure in babies.
Pyridoxine hydrochloride (Fertisure-F) taken by mouth (oral) is available without a prescription. Injectable Pyridoxine hydrochloride (Fertisure-F) must be given by a healthcare professional.
Pyridoxine hydrochloride (Fertisure-F) may also be used for purposes not listed in this medication guide.
Selenium (Fertisure-F) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Selenium (Fertisure-F) is not produced in the body, but it is needed for proper thyroid and immune system function.
Selenium (Fertisure-F) is used to treat or prevent Selenium (Fertisure-F) deficiency.
Selenium (Fertisure-F) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.
Not all uses for Selenium (Fertisure-F) have been approved by the FDA. Selenium (Fertisure-F) should not be used in place of medication prescribed for you by your doctor.
Selenium (Fertisure-F) may also be used for purposes not listed in this product guide.
Cyanocobalamin is a man-made form of Vitamin B12 (Fertisure-F). Vitamin B12 (Fertisure-F) is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.
Cyanocobalamin is used to treat Vitamin B12 (Fertisure-F) deficiency in people with pernicious anemia and other conditions.
Cyanocobalamin may also be used for purposes not listed in this medication guide.
Zinc (Fertisure-F) is a naturally occurring mineral. Zinc (Fertisure-F) is important for growth and for the development and health of body tissues.
Zinc (Fertisure-F) sulfate is used to treat and to prevent Zinc (Fertisure-F) deficiency.
Zinc (Fertisure-F) sulfate may also be used for purposes not listed in this medication guide.
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Ferrous gluconate (Fertisure-F) is used to build up the blood in anemia.
A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Fertisure-F) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]
An essential amino acid that is physiologically active in the L-form. [PubChem]
Lycopene (Fertisure-F), an antioxidant, is indicated for the treatment and prevention of cancer, cataract, asthma, HPV infection, atherosclerosis, CVD and prostate cancer. Lycopene (Fertisure-F) is a good anti-inflammatory agent and anti-oxidant.
Pyridoxine hydrochloride (Fertisure-F) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride (Fertisure-F) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Vitamin B12 (Fertisure-F) (commonly known as Vitamin B12 (Fertisure-F)) is the most chemically complex of all the vitamins. Vitamin B12 (Fertisure-F)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Vitamin B12 (Fertisure-F) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of cyanocobalamin are bacteria and archaea. Higher plants do not concentrate cyanocobalamin from the soil and so are a poor source of the substance as compared with animal tissues. Vitamin B12 (Fertisure-F) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products.
Zinc (Fertisure-F) Capsule: Each capsule contains Zinc (Fertisure-F) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, Zinc (Fertisure-F) 3 mg, Zinc (Fertisure-F) (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, Zinc (Fertisure-F) 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.
Zinc (Fertisure-F) Syrup: Each 5 mL contains Zinc (Fertisure-F) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, Zinc (Fertisure-F) 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.
Use Ferrous gluconate (Fertisure-F) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Ferrous gluconate (Fertisure-F).
Use Folic acid (Fertisure-F) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Folic acid (Fertisure-F).
Use Pyridoxine hydrochloride (Fertisure-F) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (Fertisure-F) (vitamin b6).
Use Selenium (Fertisure-F) lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Selenium (Fertisure-F) lotion.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsIron-deficiency anemia: Prevention and treatment of iron-deficiency anemias
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Folic acid (Fertisure-F) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.
Folic acid (Fertisure-F) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Fertisure-F) either through their diet or supplements to prevent infant spinal cord birth defects.
How to use Folic acid (Fertisure-F)Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.
Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.
If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.L-arginine (Fertisure-F) is used for congestive heart failure, chest pain, high blood pressure, and coronary artery disease. L-arginine (Fertisure-F) is also used for recurrent pain in the legs due to blocked arteries, decreased mental capacity in the elderly, erectile dysfunction, male infertility. L-arginine (Fertisure-F) for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsPyridoxine hydrochloride (Fertisure-F) deficiency: Treatment and prevention of Pyridoxine hydrochloride (Fertisure-F) (vitamin B) deficiency.
Off Label UsesEthylene glycol poisoning
The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride (Fertisure-F) as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride (Fertisure-F) in this condition.
Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride (Fertisure-F) is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Selenium (Fertisure-F) is used as a dietary supplement mainly in the treatment of Selenium (Fertisure-F) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Selenium (Fertisure-F) levels in body called Kashin-Beck Disease. Selenium (Fertisure-F) supplements are also used in patients with HIV/ AIDS to maintain the adequate Selenium (Fertisure-F) levels.
1 cap once daily.
Dosage FormsExcipient information presented when available (limited, particularly for generics); consult specific product labeling.
Tablet,
Oral:Generic: 240 mg [elemental iron 27 mg], 324 mg [elemental iron 38 mg]
Tablet,
Oral [preservative free]:Ferrous gluconate (Fertisure-F): 240 mg [elemental iron 27 mg] [corn free, dairy free, egg free, fragrance free, gluten free, no artificial flavor(s), sodium free, soy free, starch free, sugar free, wheat free, yeast free; contains fd&c blue #1 aluminum lake, fd&c yellow #6 aluminum lake]
Generic: 324 mg [elemental iron 37.5 mg]
Dosing: Adult
Note: Immediate release oral iron products are preferred for treatment of iron deficiency anemia; enteric coated and slow/sustained release preparations are not desired due to poor absorption (Hershko 2014; Liu 2012). Dose expressed in terms of elemental iron; Ferrous gluconate (Fertisure-F) contains ~12% elemental iron.
Iron-deficiency anemia, prevention in areas where anemia prevalence is ≥40% (off-label use):
Oral: Menstruating women (nonpregnant females of reproductive potential): 30 to 60 mg elemental iron/day for 3 consecutive months in a year (WHO 2016a).
Iron-deficiency anemia, treatment:
Oral: 65 to 200 mg elemental iron/day (Liu 2012; Schrier 2019; Stoltzfus 1998; WHO 2001); may administer in up to 3 divided doses. Note: Alternate-day dosing (eg, every other day or Monday, Wednesday, Friday) has been shown to result in greater absorption of iron; some experts recommend this dosing schedule in patients who can maintain adherence (Schrier 2019; Stoffel 2017).
Dosing: Geriatric
Lower doses (15 to 50 mg elemental iron/day) may have similar efficacy and less GI adverse events (eg, nausea, constipation) as compared to higher doses (eg, 150 mg elemental iron/day) (Rimon 2005).
Dosing: Pediatric
Note: Doses expressed as elemental iron. Ferrous gluconate (Fertisure-F) contains ~12% elemental iron.
Iron deficiency, prevention in areas where anemia prevalence is >40%:
Oral:Infants ≥6 months and Children <2 years: 10 to 12.5 mg daily for 3 consecutive months in a year (WHO 2016b)
Children 2 years to <5 years: 30 mg daily for 3 consecutive months in a year (WHO 2016b)
Children ≥5 to 12 years: 30 to 60 mg daily for 3 consecutive months in a year (WHO 2016b)
Adolescent menstruating females (non-pregnant females of reproductive potential): 30 to 60 mg daily for 3 consecutive months in a year (WHO 2016a)
Iron deficiency, treatment:
Oral: Children and Adolescents: 3 to 6 mg/kg/day in 3 divided doses; suggested maximum daily dose: 200 mg/day (ASPEN Pediatric Nutrition Support Core Curriculum [Corkins 2015]; Kliegman 2016)
Usual Adult Dose for Megaloblastic Anemia1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.
Usual Adult Dose for Folic acid (Fertisure-F) Deficiency
400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Folic acid (Fertisure-F) Deficiency
Infant:
0.1 mg orally, intramuscularly, subcutaneously or IV once a day.
Child:
Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.
4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.
Usual Pediatric Dose for Vitamin/Mineral Supplementation
Recommended daily allowance (RDA):
Premature neonates: 50 mcg/day (15 mcg/kg/day).
Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.
Children:
1 to 3 years: 150 mcg/day.
4 to 8 years: 200 mcg/day.
9 to 13 years: 300 mcg/day.
14 years and older: 400 mcg/day.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.
Dialysis
Folic acid (Fertisure-F) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.
Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.
Other Comments
The recommended daily allowance of Folic acid (Fertisure-F) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.
There is a potential danger in administering Folic acid (Fertisure-F) to patients with undiagnosed anemia, since Folic acid (Fertisure-F) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.
Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.
Dosage depends on the severity of the catabolic state & amino acid requirement. Daily dose: 10-20ml/kg body wt equiv to 1-2g amino acids/kg body wt. Maximum daily dosage not >2g amino acids/kg body wt.
Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis:
Cycloserine: 100 to 300 mg/day orally in divided doses.
Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.
Oral contraceptives: 25 to 30 mg/day orally.Acute Intoxication:
Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.
Usual Adult Dose for Dietary Supplement:
Pyridoxine hydrochloride (Fertisure-F) Deficiency:
10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.
Usual Adult Dose for Anemia:
Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.
If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride (Fertisure-F) therapy, a different therapy should be considered.
Usual Adult Dose for Nausea/Vomiting:
Nausea and vomiting of Pregnancy:
25 mg orally every 8 hours.
Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :
Treatment: 10 to 50 mg/day.
Prophylaxis: 1 to 2 mg/kg/day
Acute Intoxication:
Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.
Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride (Fertisure-F) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride (Fertisure-F) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.
Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.
Usual Pediatric Dose for Dietary Supplement:
Pyridoxine hydrochloride (Fertisure-F) Deficiency:
5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.
Usual Pediatric Dose for Seizures:
Pyridoxine hydrochloride (Fertisure-F)-dependent seizures:
10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.
Selenium (Fertisure-F) Injection provides 40 mcg Selenium (Fertisure-F)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Selenium (Fertisure-F)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.
In adults, Selenium (Fertisure-F) deficiency states resulting from long-term TPN support, Selenium (Fertisure-F) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.
Aseptic addition of Selenium (Fertisure-F) Injection to the TPN solution under laminar flow hood is recommended. Selenium (Fertisure-F) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium (Fertisure-F) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium (Fertisure-F) is approximately 10 to 37 mcg/100 mL.
Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.
Vitamin B12 (Fertisure-F) Atlantic Laboratories is used as injections SC, IV, IM, intralumbar, and also oral. With anemia associated with Vitamin B12 (Fertisure-F) deficiency is introduced on 100-200 mcg in 2 days. In anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system - 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days. In the period of remission in the absence of events funicular myelosis maintenance dose - 100 mcg 2 times a month, in the presence of neurological symptoms - at 200-400 mcg 2-4 times a month. In acute post-hemorrhagic anemia and iron anemia by 30-100 mcg 2-3 times a week. When aplastic anemia (especially in children) - 100 micrograms before clinical improvement. When nutritional anemia in infants and preterm - 30 mcg / day during 15 days.
In diseases of the central and peripheral nervous system and neurological diseases with a pain syndrome is administered in increasing doses - 200-500 mcg, with the improvement in the state - 100 mcg / day. The course of treatment with Vitamin B12 (Fertisure-F) Atlantic Laboratories is 2 weeks. In traumatic lesions of peripheral nervous system - at 200-400 mcg every other day for 40-45 days.
When hepatitis and cirrhosis - 30-60 mcg / day or 100 mg every other day for 25-40 days.
Dystrophy in young children, Down syndrome and cerebral palsy - by 15-30 mcg every other day.
When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms.
In radiation sickness, diabetic neuropathy, sprue - by 60-100 mcg daily for 20-30 days.
When deficiency of Vitamin B12 (Fertisure-F) to prevent - IV or IM for 1 mg 1 time a month; for treatment - IV or IM for 1 mg daily for 1-2 weeks, the maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. Duration of treatment is determined individually.
Zinc (Fertisure-F) 1 mg/mL (Zinc (Fertisure-F) Chloride Injection, USP) contains 1 mg Zinc (Fertisure-F)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Fertisure-F)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Fertisure-F)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Fertisure-F)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Fertisure-F)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Fertisure-F) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Fertisure-F).
For full term infants and children up to 5 years of age, 100 mcg Zinc (Fertisure-F)/kg/day
(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Fertisure-F)/kg/day (0.3 mL/kg/day) is suggested.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.
How suppliedZinc (Fertisure-F) 1 mg/mL (Zinc (Fertisure-F) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).
Store at 20 to 25°C (68 to 77°F).
HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004
See also:
What other drugs will affect Ferrous gluconate (Fertisure-F)?
Metformin In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean cmax and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.
Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.
Probenecid As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid.
Drug / Laboratory Test Interactions
As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictís and Fehlingís solutions and also with Clinitest® tablets.
See also:
What other drugs will affect Folic acid (Fertisure-F)?
Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Fertisure-F). Folic acid (Fertisure-F) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Fertisure-F) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Fertisure-F) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Fertisure-F) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Fertisure-F) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Fertisure-F).
ALPHA TOCOPHERYL/SELECTED ANTICOAGULANTS - Increased effect of the latter drug
DI-TRIVALENT CATIONS/TETRACYCLINES - Decreased effect of the latter drug
Moderate Interaction:
Assess the risk to the patient and take action as needed.
POLYVALENT CATIONS/ELTROMBOPAG - Decreased effect of the latter drug
SELECTED MINERALS/ORAL IRON SUPPLEMENTS - Decreased effect of the latter drug
DI-; TRIVALENT CATIONS/CHLOROQUINE; HYDROXYCHLOROQUINE - Decreased effect of the former drug
ORAL MULTIVALENT CATIONS/ORAL BISPHOSPHONATES - Decreased effect of the latter drug
FAT SOLUBLE VITAMINS/ORLISTAT - Decreased effect of the former drug
ORAL ZINC PRODUCTS/SELECTED ORAL QUINOLONES - Decreased effect of the latter drug
See also:
What other drugs will affect Pyridoxine hydrochloride (Fertisure-F)?
Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine
Increased need for Pyridoxine hydrochloride (Fertisure-F).
Levodopa
Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride (Fertisure-F).)
Phenytoin
Phenytoin serum levels may be decreased.
Incompatibility
Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).
Laboratory Test Interactions
May result in false-positive urobilinogen in the spot test using Ehrlich reagent.
See also:
What other drugs will affect Selenium (Fertisure-F)?
Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination
Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification
Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification
Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification
Dolutegravir: Selenium (Fertisure-F) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Selenium (Fertisure-F). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Selenium (Fertisure-F). Consider therapy modification
Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification
Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification
PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification
Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification
Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification
In an application of Vitamin B12 (Fertisure-F) Atlantic Laboratories with hormonal contraceptives for oral administration may decrease the concentration of cyanocobalamin in plasma.
In an application with anticonvulsant drugs decreased cyanocobalamin absorption from the gut.
In an Vitamin B12 (Fertisure-F) Atlantic Laboratories application with neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, drugs potassium decreased cyanocobalamin absorption from the gut.
Cyanocobalamin may exacerbate allergic reactions caused by thiamine.
When parenteral application of chloramphenicol may decrease the hematopoietic effects of cyanocobalamin with anemia.
See also:
What other drugs will affect Zinc (Fertisure-F)?
Zinc (Fertisure-F) reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for Zinc (Fertisure-F).
Absorption of cyanocobalamin from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H2-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.
Parenteral chloramphenicol may attenuate the effect of Zinc (Fertisure-F) in anaemia.
Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and Zinc (Fertisure-F) antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; Zinc (Fertisure-F) may decrease serum-phenytoin concentrations.
There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.
Ascorbic acid may increase the absorption of iron-deficiency states.
Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.
The absorption of Zinc (Fertisure-F) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Fertisure-F) supplements reduce the absorption of copper, ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.
