Dioflam (dios lifescience)

Contraindications

Dioflam (DIOS LIFESCIENCE) is contraindicated in the following situations: Patients sensitive to Aceclofenac (Dioflam (DIOS LIFESCIENCE)), Paracetamol (Dioflam (DIOS LIFESCIENCE)) or to any of the excipients of the product. Patients in whom aspirin or other Non-Steroidal Anti-Inflammatory Drug, precipitate attacks of bronchospasm, acute rhinitis or urticaria or patients hypersensitive to drugs. Patients with active or suspected peptic ulcer or gastrointestinal bleeding or bleeding disorders. Patients with severe heart failure, hypertension, hepatic or renal insufficiency. Third trimester of pregnancy.

Undesirable effects

Paracetamol (Dioflam (DIOS LIFESCIENCE)): Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Aceclofenac (Dioflam (DIOS LIFESCIENCE)): Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.

Potentially Fatal: Paracetamol (Dioflam (DIOS LIFESCIENCE)): Very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage. Aceclofenac (Dioflam (DIOS LIFESCIENCE)): Severe GI bleeding; nephrotoxicity.

Therapeutic indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or Paracetamol (Dioflam (DIOS LIFESCIENCE)) is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Paracetamol (Dioflam (DIOS LIFESCIENCE)). A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Oral

Pain and inflammation

Adult: Each tablet contains Aceclofenac (Dioflam (DIOS LIFESCIENCE)) 100 mg and Paracetamol (Dioflam (DIOS LIFESCIENCE)) 500 mg: 1 tablet in the morning and 1 tablet in the evening. Max: 2 tablets/day.

Name of the medicinal product

Dioflam (DIOS LIFESCIENCE)

Qualitative and quantitative composition

Each film-coated tablet contains Aceclofenac (Dioflam (DIOS LIFESCIENCE)) 100 mg, Paracetamol (Dioflam (DIOS LIFESCIENCE)) 500 mg.

Dosage (Posology) and method of administration

Oral

Pain and inflammation

Adult: Each tablet contains Aceclofenac (Dioflam (DIOS LIFESCIENCE)) 100 mg and Paracetamol (Dioflam (DIOS LIFESCIENCE)) 500 mg: 1 tablet in the morning and 1 tablet in the evening. Max: 2 tablets/day.

Interaction with other medicinal products and other forms of interaction

Paracetamol (Dioflam (DIOS LIFESCIENCE)): Reduced absorption of cholestyramine within 1 hr of administration.

Accelerated absorption with metoclopramide.

Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity with high doses or long term administration of barbiturates, carbamazepine, hydantoins, isoniazid, rifampicin and sulfinpyrazone.

Aceclofenac (Dioflam (DIOS LIFESCIENCE)): May increase the plasma concentrations of lithium and digoxin.

Increased nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. May enhance activity of anticoagulants. May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hours of methotrexate administration. Risk of convulsions with quinolones. Potentially fatal.