Severe forms of heart, kidney or liver failure, pregnancy, lactation, childhood and old age.
The effect is reduced by inducers of microsomal oxidation (antiepileptic drugs, rifampicin), is incompatible with oral contraceptives.
The capsule is rigid
Vaginal bleeding, acne, seborrhea, fluid retention, weight gain, hirsutism, voice changes, headache, hot flashes, nervousness, depression, seizures, changes in appetite, transient increase in liver transaminases, changes in libido, decreased breast volume.
Endometriosis (including complicated infertility).
After oral administration of a single dose of 2.5 mg Cmax it is reached after 2 hours. A stable concentration with repeated administration is noted on the third day. Accumulation of the drug was not noted. T1/2 - 27 hours — It is excreted 40-45% in the urine and 30-35% in the feces.
Dimetriose
Gestrinone
Inside, 1 capsule (2.5 mg) 2 times a week for 6 months, the first capsule is taken on the 1st day of menstruation, the second-on the 4th day, then taken on the same 2 days of the week during the course of treatment.
