Symptoms: increased severity of dose-dependent side effects.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
epilepsy,
chronic renal failure of the 2nd-3rd degree (Creatinine Cl less than 40 ml / min),
children and adolescents under 18 years of age — with acute and chronic disorders of the cerebral circulation, the consequences of ischemic and hemorrhagic strokes, traumatic brain injuries, elective neurosurgical operations, osteochondrosis, multiple sclerosis, chronic non-specific lung diseases with signs of respiratory and pulmonary-heart failure, chronic cerebrovascular insufficiency due to atherosclerosis and hypertension, migraine, Meniere's disease,
children under 12 years of age with vegetative-vascular dystonia of the parasympathetic type.
With caution: Dimephosphone® it is well tolerated by patients. When applied to the mucous membranes, it can cause irritation, in this case, it is necessary to dilute the Dimephosphone solution® twice as much.
Interactions of Dimephosphone® with other drugs, it was not detected.
Colorless or yellowish, transparent or opalescent liquid with a peculiar smell.
Dyspeptic phenomena, drowsiness and deterioration of concentration (by the 3rd-4th day of taking the drug pass).
According to the recipe.
Influence on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. If drowsiness appears in the first days of taking the drug, you should refrain from driving vehicles and activities that require increased attention and a high rate of psychomotor reactions.
It has a bitter taste. Children are recommended to drink milk, fruit juice, sweet tea.
Inside, as part of complex therapy:
acute and chronic disorders of cerebral circulation,
consequences of ischemic and hemorrhagic strokes,
traumatic brain injuries,
elective neurosurgical operations,
osteochondrosis,
multiple sclerosis,
chronic non-specific lung diseases with signs of respiratory and pulmonary-heart failure (the use of dimephosphone does not relieve suffocation attacks and does not affect the frequency of use of beta-adrenomimetic aerosols),
vegetative-vascular dystonia of the parasympathetic type,
chronic cerebrovascular insufficiency due to atherosclerosis and hypertension,
migraine,
Meniere's disease,
diseases of the respiratory system,
the acidosis,
atopic bronchial asthma,
hay fever.
Externally:
infectious-inflammatory-allergic diseases and damage to the skin and mucous membranes: wounds, suture areas and places of exit of Ilizarov spokes, erysipelas,
in dermatology is a comprehensive treatment of skin diseases (acne, oily seborrhea, rosacea),
prevention of radiation mucositis.
Dimephosphone® it exhibits antiacidotic, membrane-stabilizing, anti-inflammatory and antioxidant properties, normalizes blood flow and metabolism of brain tissues, reduces heart and lung failure, improves the regulation of blood circulation, including brain circulation.
The antiacidotic effect is realized due to the intensification of the renal and pulmonary mechanisms of the regulation of CSF, the strengthening of intra-organ blood flow and tissue metabolism, as well as Dimephosphone® reduces the content of lactic and pyruvic acids in the brain tissues.
Dimephosphone® it stabilizes cell membranes, restores the reactivity of brain vessels, improves the functions of the large hemispheres and the brain stem, reduces the depth of consciousness disorders, restores the sleep—wake cycle, reflexes, the arcs of which are closed through the stem sections, reduces the severity of pyramidal, cerebellar, vestibular, visual and auditory disorders.
The antioxidant effect is carried out by preventing the activation of lipid peroxidation and increasing the activity of antioxidant enzymes in the brain tissues.
Dimephosphone® it enhances the energy processes in the brain both directly, acting directly on the mitochondria, and indirectly, stimulating the pituitary-thyroid system, increasing the consumption of thyroid hormones by tissues, which is accompanied by the activation of energy and catabolic processes in the mitochondria of cells. It exhibits the properties of certain neurotransmitters (GABA-positive, N-choline and dopaminergic activity).
Dimephosphone® reduces heart and lung failure, restoring the resistivity of peripheral vessels (arterial and venous).
Dimephosphone® improves the regulation of cerebral circulation, without having a pronounced vasodilating effect, but has a positive effect on the metabolism of brain tissues in their ischemia, improves venous outflow. The effectiveness of the clinical use of the drug in various forms of cerebrovascular insufficiency is associated with its ability to increase the resistance of nerve cells to ischemia, with a decrease in edema and, in this regard, improve microcirculation.
When applied topically, Dimephosphone® it has an anti-inflammatory and antiseptic effect, increases the protective functions of the skin and mucous membranes.
Dimephosphone® after a single dose, it is absorbed quite completely, easily penetrates through the histohematic barriers and is distributed to various organs and tissues, while Cmax in the blood, it is observed during the first hour after administration of the drug, 3 hours after administration of Cmax it is detected in the brain, heart, and spleen.
Three days after a single administration of Dimephosphone® only trace concentrations of it remain in the body.
Dimephosphone is excreted® in unchanged form, mainly with urine in an amount of 11-15% (up to 70% of the excreted amount is excreted during the first 12 hours). No more than 0.5% is excreted in the feces.
In a place protected from light, at a temperature not exceeding 25 °C.
Keep out of reach of children.
Shelf life of the drug Dimephosphone®3 года.Do not use after the expiration date indicated on the package.
| Solution for oral and external use | 100 ml |
| active substance: | |
| dimethyloxobutylphosphonyldimethylate | 15 g |
| auxiliary substance: purified water-up to 100 ml |
Solution for oral and external use 15%. 100 or 200 ml each in orange or brown glass bottles. The bottle together with the measuring cup is placed in a pack of cardboard.
Currently, data on the use of the drug during pregnancy is not enough to assess the teratogenic effect of Dimephosphone®.With this in mind, Dimephosphone® it should be prescribed during pregnancy and during breastfeeding only if the intended benefit from its use exceeds the potential risk to the fetus or infant.
Animal studies have not revealed a damaging effect on the embryo and its development.
Inside, after eating, with water.
The course of treatment depends on the nature of the disease and lasts from 3 days to 2 months.
In the complex therapy of the following diseases and conditions:
In acute and chronic disorders of cerebral circulation, the consequences of ischemic and hemorrhagic strokes, traumatic brain injury - adults 15 ml (1 tbsp.spoon) 3-4 times a day. The course duration is 2-3 weeks, in some cases-up to 6 weeks.
For elective neurosurgical operations - 15 ml each (1 tbsp.spoon) for 5 days before and 2 months after the operation.
With osteochondrosis — adults: 10 ml (1 Dec.spoon) 3-4 times a day for 2-3 weeks, improvement is observed on the 8-10 th day of treatment.
For multiple sclerosis - adults 100 mg / kg (45 ml) per day (15 ml (1 tbsp.spoon) 3 times a day) for 10 days in the autumn-spring period monthly.
In chronic non-specific lung diseases with signs of respiratory and pulmonary-heart failure - adults 15 ml (1 tbsp.spoon) 3-4 times a day. The course is 7-10 days. The Use Of Dimephosphone® it does not relieve suffocation attacks and does not affect the frequency of use of beta-adrenomimetic aerosols.
In vegetative-vascular dystonia of the parasympathetic type - adults 15 ml (1 tbsp.spoon) 3 times a day for 2-3 weeks, for children over 12 years-50 mg/kg (10-15 ml) 3 times a day for 3 weeks.
In patients with chronic cerebrovascular insufficiency due to atherosclerosis and hypertension - 15 ml each (1 tbsp.spoon) 3 times a day for 2-3 weeks.
For migraines - 15 ml each (1 tbsp.spoon) 3 times a day for 2-3 weeks.
In Meniere's disease - 15 ml each (1 tbsp.spoon) 3 times a day for 3 weeks.
In diseases of the respiratory system, the acidosis, atopic bronchial asthma and hay fever - adults are prescribed 15-25 ml, children are prescribed at a dose of 75-100 mg/kg: up to 3 years-5 ml (1 teaspoon), 3-8 years-10 ml (1 des.spoon), older than 8 years — 15 ml (1 tbsp.spoon) 3 times a day, in severe cases-4 times a day for 4-5 weeks. With atopic bronchial asthma in combination with pollinosis, it is prescribed 2-3 weeks before the onset of deterioration and is taken during the entire flowering period.
Externally.
For infectious-inflammatory-allergic diseases of the skin and mucous membranes - in the form of dressings, turundum and lotions with a solution daily for 3-14 days.
In the complex treatment of acne wipe the skin 3-4 times a day, in the evening — lotions.
With erysipelas lubricate the area of inflammation 3 times a day for 3-5 days.
On the area of the seams and the exit points of the Ilizarov spokes apply daily gauze napkins soaked in Dimephosphone®, within 7-14 days.
For the prevention of radiation mucositis gauze napkins moistened with dimephosphone®, are placed in the projection of the radiation beams 20 minutes before the exposure of the dose.
V03AX Other medicinal products
