Daonil

Overdose

Symptoms: hypoglycaemia.

Treatment:

- Patient should be transferred to hospital

- Activated charcoal to be administered

- Hypoglycaemia should be treated with urgency by appropriate means

- Vital signs should be monitored and appropriate supportive measures used, including the treatment of cerebral oedema should this occur

- Observation should continue for several days in case hypoglycaemia is prolonged or recurs.

Incompatibilities

None.

Undesirable effects

Immune system disorders

Hypersensitivity reactions:

- Rash, urticaria, erythema multiforme, erythema nodosum, bullous eruptions, pruritus, exfoliative dermatitis, photosensitivity

- Altered liver enzymes values, hepatitis and cholestatic jaundice.

- Blood dyscrasias including agranulocytosis, aplastic and haemolytic anaemia, pancytopenia, leucopenia, thrombocytopenia and neutropenia

- Fever

- Stevens-Johnson syndrome

Hypersensitivity reactions affecting the skin usually occur within the first six weeks of treatment with a sulphonylurea.

Metabolism and nutrition disorders

Hypoglycaemia.

Syndrome of inappropriate secretion of antidiuretic hormone, characterised by water retention and hyponatraemia.

Gastrointestinal disorders

Nausea, heartburn, anorexia, and diarrhoea. This type of adverse reaction can be avoided if Daonil is taken during a meal. Vomiting, metallic taste, increased appetite and weight gain.

Hepatic Disorders

Intrahepatic cholestasis and acute hepatitis-like syndrome.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.

Preclinical safety data

There are no pre-clinical data of any relevance to the prescriber, which are additional to those already included in other sections.

Pharmacodynamic properties

Daonil is an orally active hypoglycaemic agent, which acts by stimulating insulin secretion.

Pharmacokinetic properties

Daonil is rapidly absorbed and is extensively bound to plasma proteins, but is not readily displaced by acidic drugs. It is excreted as metabolites in the urine and bile.

Special precautions for disposal and other handling

None