Symptoms: headache, dizziness, irritability, paresthesia, dysarthria, paresis, convulsions, psychosis, confusion or loss of consciousness (coma).
Treatment: administration of activated charcoal and maintenance (hemodialysis, administration of 200-300 mg per day of pyridoxine to stop the development of neurotoxic effects, etc.) therapy, all measures are carried out against the background of drug withdrawal.
Hypersensitivity, epilepsy, depression, severe agitation, psychosis, severe renal failure, alcoholism.
Ethionamide and isoniazid increase neurotoxicity. Incompatible with alcohol (increases the risk of epileptic seizures).
Headache, tremor, dysarthria, dizziness, convulsions, drowsiness, semi-consciousness, confusion, disorientation, accompanied by memory loss, psychosis with suicidal attempts, character change, increased irritability, aggressiveness, paresis, hyperreflexia, paresthesia, large and small attacks of clonic seizures, coma, congestive heart failure (when taking 1000-1500 mg per day), megaloblastic or sideroblastic anemia, increased serum aminotransferases, allergic reactions (pruritus).
Tuberculosis of the lungs (active form), kidneys, acute urinary tract infections.
It is rapidly absorbed into the gastrointestinal tract, the therapeutic concentration in the plasma is created after 1 hour. It is evenly distributed, penetrates into the lymphoid tissue, lung tissue, pleural and ascitic fluids, sputum, bile. Passes the placental barrier and BBB (the concentration in the cerebrospinal fluid corresponds to the concentration in the plasma, is determined in the amniotic fluid and fetal blood). It is metabolized in the liver (30%). It is mainly excreted by the kidneys (66% - detected in the urine for 24 hours, another 10% - for the next 48 hours) in unchanged form and is excreted in the faeces. A certain amount is excreted with milk.
Cycloserine
Inside. Adults 500-750 mg / day in 2-3 doses (12.5 mg / kg body weight) under the control of the drug level in the blood, in children the initial dose is from 10 mg/kg body weight per day. The dose varies depending on the therapeutic effect and the level of the drug in the blood.
