Treatment: gastric lavage and symptomatic therapy.
Hypersensitivity, pregnancy, breast-feeding (breastfeeding should be discontinued during treatment), simultaneous administration of drugs such as ergotamine and dihydroergotamine, breast-feeding up to 2 months.
Increases the effect of terfenadine, astemizole, cisapride, pimozide (possible development of arrhythmia), disopyramide, digoxin, midazolam, theophylline and cyclosporine.
Nausea, vomiting, abdominal pain, diarrhea (rarely with blood), dizziness, headache, paresthesia, transient increase in transaminases and alkaline phosphatase, development of superinfection, allergic reactions: skin (rash, redness, urticaria), angioedema, bronchospasm, anaphylactic shock (rarely).
Infections of the upper and lower respiratory tract (acute pharyngitis, tonsillitis, sinusitis, pneumonia, bronchitis, SARS), infections of the skin and soft tissues, the genitourinary system (including sexually transmitted infections, except gonorrhea), prevention of meningococcal meningitis in persons who have been in contact with the patient.
Effective on group A and B streptococci, Neisseria meningitidis, Branhamella catarrhalis, Borrelia burgdorferi, Bordetella pertussis, Listeria monocytogenes, Corynebacterium diphtheriae, Clostridium spp., Clostridium perfringens, Corynebacterium diphtheriae, Enterococcus spp., Methi-S-Sthaphylococcus, Helicobacter pylori, Peptostreptococcus spp., Porphyromonas spp., Propionibacterium acnes, Rhodococcus equi, Mycoplasma pneumoniae, Pasteurella multocida, Chlamydia trachomatis, C.pneumoniae and C.psittaci, Legionella pneumophila, Campylobacter spp., Gardnerella vaginalis. Moderately sensitive are Haemophilus influenzae, Ureaplasma urealyticum, Bacteroides fragilis and Vibrio cholerae
It is rapidly absorbed after oral administration (food intake does not affect the rate of resorption) and is detected in the blood serum after 15 min. Cmax in adults (when taking 150 mg) - 6.6 mg / l is reached after 2.2 h. Cmax in children (with a double dose of 2.5 mg / kg per day) - 8,7–10,1 g / l is determined after 2 hours. Effective concentrations in the blood are maintained for 1 day with a double (with an interval of 12 hours) intake. The equilibrium concentration in the plasma is determined on the 2-4 th day. It penetrates well into the tissues (especially the lungs), the palatine tonsils and the prostate gland, as well as into the cells (especially neutrophilic leukocytes and monocytes, stimulates their phagocytic activity). The binding to plasma proteins is 96%, is saturable and decreases at concentrations above 4 mg / l. It is partially metabolized, more than half of the active substance is excreted unchanged mainly by the intestines and kidneys. T1/2 in adults, after a single dose, it is on average 10.5 hours, in children-20 hours.
Coroxin (Roxithromycin)
Roxithromycin
Inside, before eating. Adults: 150 mg 2 times a day, in case of liver failure, 150 mg is prescribed 1 time a day.
For children: at the rate of 5-8 mg / kg / day in 2 doses for no more than 10 days. The oral suspension is prepared immediately before use: it is necessary to fill the measuring spoon attached in the package with water, place 1/2 or 1 table. p. o. d/oral suspension in it, wait a few seconds for the tablet to break up into small granules and immediately give it to the child, then drink water.
