individual hypersensitivity to the components of the drug,
impaired liver and kidney function,
pregnancy,
lactation period,
children's age (up to 8 years).
No pharmacological interactions with other drugs were detected when Colbiocin was applied topically.
Eye drops: colorless or light yellow transparent liquid.
Eye ointment: semi-solid yellow mass.
Eye drops contain sodium sulfite, this component of the drug can provoke allergic reactions and severe asthma attacks in people who are sensitive to it (especially asthmatics).
Since rare cases of bone marrow hypoplasia have been reported due to prolonged topical use of chloramphenicol, the drug should be used for short periods of time and under the supervision of an ophthalmologist.
Prolonged topical use of antibiotics may cause symptoms of local irritation (short-term conjunctival hyperemia). Cases of hypersensitivity symptoms in the form of burning, angioedema, urticaria, bullous and spot-papular dermatitis have been reported, which requires discontinuation of the drug.
In the absence of significant clinical improvement within a relatively short period of time or the appearance of allergic reactions to the components of the drug, it is necessary to discontinue treatment and prescribe appropriate therapy.
conjunctivitis (catarrhal, purulent, trachoma),
blepharitis,
blepharoconjunctivitis,
bacterial keratitis,
septic ulcer of the cornea,
dacryocystitis.
Combined antibacterial drug.
Chloramphenicol - broad-spectrum antibiotic, inhibits the synthesis of proteins of sensitive microorganisms, is active against gram-positive and gram-negative bacteria, Mycoplasma spp., Ricketsia spp., Chlamydia spp., not active in relation to Pseudomonas aeruginosa, mushrooms.
Tetracycline - broad-spectrum antibiotic, inhibits bacterial protein synthesis at the RNA level, has a bacteriostatic effect. It is active against Gram-negative bacteria, Chlamydia spp., Mycoplasma spp., Ricketsia spp., Entamoeba histolytica. The resistance of microorganisms develops slowly.
Colistin - an antibiotic that is isolated from Bacillus polymyxa (var. colistinus). It has a bactericidal effect on most Gram-negative bacteria (including Pseudomonas spp., Haemophilus spp.), active against fungi. There is no cross-resistance with broad-spectrum antibiotics, with which colistin shows synergy.
At a temperature not exceeding 25 °C. After opening, store the drug in the refrigerator at t 2-8 °C, use for 15 days.
Keep out of reach of children.
Shelf life of the drug Colbiocinpowder for the preparation of eye drops 120 mg — 2 years.
eye ointment — 3 years. After opening the package-30 days.
Do not use after the expiration date indicated on the package.
| Powder for the preparation of eye drops | 1 ml |
| (ready-to-use solution) | |
| active components contained in the lid tank: | |
| rolitetracycline | 0.005 g |
| (equivalent to 0.421 g tetracycline) | |
| chloramphenicol | 0.004 g |
| sodium colistimethate | 180,000 IU |
| filler contained in the lid tank: | |
| sodium sulfite | 0.001 g |
| fillers contained in the solvent: benzalkonium chloride (preservative), sodium tetraborate, boric acid, sodium edetate, polysorbate 80, sterile distilled water |
in bottles of 5 ml (complete with lid-tank and lid-dropper), in a pack of cardboard 1 set.
| Eye ointment | 1 g |
| tetracycline | 0.005 g |
| chloramphenicol | 0.01 g |
| colistimethate sodium | 180,000 IU |
| excipients: vaseline oil, lanolin, eye vaseline |
in aluminum tubes of 5 g, in a pack of cardboard 1 tube.
Contraindicated in pregnancy. Breastfeeding should be discontinued for the duration of treatment.
Eye drops
Conjunctival, 1-2 drops 3-4 times a day or according to the individual prescription of the attending physician.
Terms of use of the bottle
1. Following the existing notches on the aluminum capsule of the bottle, tear off the upper circumference of the capsule, and then — the side.
2. Remove the cap from the bottle and adjust the tank to it.
3. Push the red cap of the tank into the bottle, and then shake the bottle vigorously to dissolve the powder in it.
4. Remove the tank completely and put the dropper (pipette) on the bottle. Remove the cap from the dropper (pipette) and, turning the bottle over, squeeze out a drop.
Eye ointment: put in the lower conjunctival arch 3-4 times a day. When combined with the use of eye drops, it is enough to use eye ointment 1 time at night.
S01AA30 Antibiotics in combination
