Pheochromocytoma, acute cerebrovascular accident, hypotension, collapse, severe renal failure, stenosis of the aortic mouth, severe forms of pulmonary hypertension, intoxication with cardiac glycosides, pregnancy.
Hypotension (including orthostatic), moderate increase in blood pressure and heart rate (at the beginning of administration), nausea, vomiting (with rapid intravenous administration), rarely-tissue necrosis at the injection site (with intravenous administration).
There are no data on the use of doses in children exceeding 5 mg/kg.
Ventricular fibrillation (including against the background of resistance to electro-pulse therapy), ventricular tachycardia.
Increases the duration of the action potential and the effective refractory period of Purkinje fibers and ventricular cardiomyocytes. The antifibrillation effect usually manifests itself 5-15 minutes after administration, but in some patients-even after a few hours.
In a place protected from light, at a temperature not exceeding 25 °C (do not freeze).
Keep out of reach of children.
The shelf life of the drug Bracelet®5 лет.Do not use after the expiration date indicated on the package.
1 ml of the solution for injection contains bretilia tosylate 50 mg, in ampoules of 2 and 10 ml.
V/v, v/m. Adults - in / in quickly (against the background of resuscitation measures) — 5 mg / kg of undiluted drug, in the absence of an effect for 5 minutes, re-enter the same dose or increase it to 10 mg/kg with simultaneous administration. For less serious violations of the ventricular rhythm-enter more slowly, in a diluted form (the final concentration is not more than 10 mg / ml): dilute 1 part of the drug in 4 parts of a 5% glucose solution or 0.9% sodium chloride solution.
Infusion: the diluted solution is administered for at least 8 minutes (preferably for 15-30 minutes). If the arrhythmia persists, this dose can be repeated at intervals of 1-2 hours, when the arrhythmia stops, maintenance therapy is performed — a diluted solution is continuously poured at a rate of 1-2 mg/min or administered at a dose of 5-10 mg/kg for 15-30 minutes every 6 hours.
Intravenous administration: 5-10 mg / kg in the form of an undiluted solution after 6-8 hours (with repeated injections, changing the injection site, no more than 5 ml in the same place).
C01BD02 Bretilia tosylate
