To date, no cases of overdose accompanied by any clinical symptoms have been described. However, as with an overdose of any drug, symptomatic therapy should be carried out with monitoring of the functions of vital organs and regular monitoring of the patient's condition.
individual intolerance to the drug,
allergic and autoimmune diseases (urticaria, Quincke's edema, Lyell's syndrome, systemic connective tissue diseases),
pregnancy,
lactation period,
children's age.
White powder or a porous mass without smell.
In some cases, nausea and dizziness may occur. If any of the side effects listed in the instructions are aggravated or the patient has noticed any other side effects not listed in the instructions, you should inform your doctor.
According to the recipe.
Taking into account the possibility of dizziness, care should be taken when driving vehicles and working with precise mechanisms.
In adults in the complex therapy of the following diseases and conditions:
secondary immunodeficiency states that develop after severe injuries against the background of purulent-septic and purulent-destructive processes,
after extensive surgical procedures,
chronic septic conditions with anergy phenomena,
infectious diseases (viral hepatitis, tuberculosis, chlamydia).
Gamma-D-glutamyl-tryptophan sodium is a dipeptide with an immunostimulating effect. It stimulates cellular and humoral immunity. Increases antibacterial and antiviral resistance. The pharmacological effect is determined by increased differentiation and proliferation of T-lymphocyte precursors, stimulation of IL-2 production, increased expression of IL-2 receptors and markers of T-cell differentiation, and restoration of the immunoregulatory index. Application of the drug Bestim® in the complex therapy of diseases accompanied by secondary immunodeficiency, it significantly increases its effectiveness. The drug is effective when included in the complex therapy of viral diseases accompanied by insufficiency of the cellular link of immunity.
The distribution of the drug in the body is limited to the extracellular water phase. The drug is quickly removed from the systemic circulation — the average time of its circulation is 10-11 minutes, the elimination rate is characterized by a high clearance-25-30 ml/kg / min. The drug is excreted from the body in the form of metabolites in the urine and feces.
In a place protected from light, at a temperature of 2-10 °C.
Keep out of reach of children.
Shelf life of the drug Bestim®2 года.Do not use after the expiration date indicated on the package.
Instructions for medical useBestim®
Instructions for medical use-RU no. R N003335/01
Last modified date: 10.05.2017
Dosage formLyophilizate for the preparation of a solution for intramuscular administration
Composition1 ampoule-active ingredient: "Bestim®"(gamma-D-glutamyl-tryptophan sodium) - 100 mcg, auxiliary components: sodium chloride-1.0 mg, mannitol -9.0 mg.
Description of the dosage formWhite powder or porous mass, odorless
Pharmacological GroupImmunostimulating agent
PharmacodynamicsGamma-D-glutamyl-tryptophan sodium is a dipeptide with an immunostimulating effect. It stimulates cellular and humoral immunity. Increases antibacterial and antiviral resistance. The pharmacological effect is determined by increased differentiation and proliferation of T-lymphocyte precursors, stimulation of interleukin-2 production, increased expression of interleukin-2 receptors and markers of T-cell differentiation, and restoration of immunoregulatory
the index. Application of the drug Bestim® in the complex therapy of diseases accompanied by secondary immunodeficiency, it significantly increases its effectiveness. The drug is effective when included in the complex therapy of viral diseases accompanied by insufficiency of the cellular link of immunity.
PharmacokineticsThe distribution of the drug in the body is limited to the extracellular water phase. The drug is quickly removed from the systemic circulation - the average time of its circulation is 10-11 minutes, the elimination rate is characterized by a high clearance-25-30 ml/kg / min. The drug is excreted from the body in the form of metabolites in the urine and feces.
IndicationsIn adults, in the complex therapy of secondary immunodeficiency conditions that develop after severe injuries against the background of purulent-septic and purulent-destructive processes, after extensive surgical interventions, in chronic septic conditions with anergy phenomena, as well as in infectious diseases (viral hepatitis, tuberculosis, chlamydia).
ContraindicationsIndividual drug intolerance, allergic and autoimmune diseases (urticaria, Quincke's edema, Lyell's syndrome, systemic connective tissue diseases), pregnancy and lactation, childhood.
Method of administration and dosageIntramuscularly, 100 mcg in a volume of 1 ml of water for injection 1 time per day daily. The course of treatment is five injections.
Side effectsIn some cases, nausea and dizziness may occur. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
OverdoseTo date, no cases of overdose accompanied by any clinical symptoms have been described. However, as with an overdose of any drug, symptomatic therapy should be carried out with monitoring of the functions of vital organs and regular monitoring of the patient's condition.
InteractionWith simultaneous use of Bestim® increases the clinical effectiveness of anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide, ethambutol, ciprofloxacin) in the complex therapy of pulmonary tuberculosis, antibiotics of various groups (azithromycin, rovamycin, doxycycline) and antimicrobial drugs of the fluoroquinolone group (lomefloxacin, sparfloxacin) in the complex therapy of urogenital chlamydia, antiviral drug ribavirin in the complex therapy of viral hepatitis C.
Special instructionsGiven the possibility of dizziness, you should be careful when driving vehicles and working with precise mechanisms.
Release formLyophilizate for the preparation of a solution for intramuscular administration. 100 micrograms in an ampoule of colorless glass. 5 ampoules in a cassette contour cell package. 1 cassette contour cell package together with instructions for use in a pack of cardboard.
Storage conditionsIn a place protected from light, at a temperature of 2 to 10 °C. Keep out of reach of children.
Expiration date2 years.
Do not use after the expiration date.
Conditions of supply of pharmaciesThey are released on prescription.
Бестим® - инструкция по медицинскому применению - РУ № Р N003335/01 от 2010-05-06| Lyophilizate for the preparation of a solution for intramuscular administration | 1 amp. |
| active substance: | |
| Bestim® (gamma-D-glutamyl - tryptophan sodium) | 100 mcg |
| excipients: sodium chloride-1 mg, mannitol-9 mg |
Lyophilizate for the preparation of a solution for intramuscular administration. 100 micrograms in an ampoule of colorless glass. 5 amp. in a cassette contour cell package. 1 the cassette contour cell packaging is placed in a cardboard pack.
In/m, 100 mcg in 1 ml of water for injection, 1 time per day daily. The course of treatment is 5 injections.
L03AX Other Immunostimulants
