See also:
What is the most important information I should know about Codeine (Benadryl Capsules, Austria)?
Codeine (Benadryl Capsules, Austria) Sulfate is contraindicated for postoperative pain management in children who have undergone tonsillectomy and/or adenoidectomy.
Codeine (Benadryl Capsules, Austria) Sulfate is contraindicated in patients with known hypersensitivity to Codeine (Benadryl Capsules, Austria) or any components of the product. Persons known to be hypersensitive to certain other opioids may exhibit cross-sensitivity to Codeine (Benadryl Capsules, Austria).
Codeine (Benadryl Capsules, Austria) Sulfate is contraindicated in patients with respiratory depression in the absence of resuscitative equipment.
Codeine (Benadryl Capsules, Austria) Sulfate is contraindicated in patients with acute or severe bronchial asthma or hypercarbia.
Codeine (Benadryl Capsules, Austria) Sulfate is contraindicated in any patient who has or is suspected of having paralytic ileus.
See also:
What is the most important information I should know about Diphenhydramine (Benadryl Capsules, Austria)?
Hypersensitivity to Diphenhydramine (Benadryl Capsules, Austria), other structurally related antihistamines, or any component of the formulation; neonates or premature infants; breast-feeding
Additional contraindications:
Parenteral: Use as a local anestheticOTC labeling: When used for self-medication, do not use in children <6 years, to make a child sleep, or with any other Diphenhydramine (Benadryl Capsules, Austria)-containing products (including topical products)
See also:
What are the possible side effects of Codeine (Benadryl Capsules, Austria)?
Applies to Codeine (Benadryl Capsules, Austria): oral solution, oral syrup, oral tablet, oral tablet extended release
In addition to its needed effects, some unwanted effects may be caused by Codeine (Benadryl Capsules, Austria). In the event that any of these side effects do occur, they may require medical attention.
Major Side EffectsYou should check with your doctor immediately if any of these side effects occur when taking Codeine (Benadryl Capsules, Austria):
Incidence not known:
If any of the following symptoms of overdose occur while taking Codeine (Benadryl Capsules, Austria), get emergency help immediately:
Symptoms of overdose:
Some of the side effects that can occur with Codeine (Benadryl Capsules, Austria) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
See also:
What are the possible side effects of Diphenhydramine (Benadryl Capsules, Austria)?
Applies to acetaminophen / Diphenhydramine (Benadryl Capsules, Austria): tablets
Other dosage forms:
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; upset stomach; vomiting; weakness.
Seek medical attention right away if any of these SEVERE side effects occur while taking acetaminophen / Diphenhydramine (Benadryl Capsules, Austria):
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, drowsiness, lightheadedness, or headache; severe or persistent loss of appetite; stomach pain; tremor; trouble sleeping; unusual fatigue; vision changes; yellowing of the skin or eyes.
Codeine (Benadryl Capsules, Austria) sulfate is an opioid analgesic indicated for the management of mild to moderately severe pain where the use of an opioid analgesic is appropriate.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Diphenhydramine (Benadryl Capsules, Austria) in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when Diphenhydramine (Benadryl Capsules, Austria) in the oral form is impractical.
Antihistaminic
For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
Motion sickness
For active treatment of motion sickness.
Antiparkinsonism
For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.
Codeine (Benadryl Capsules, Austria) is an opioid pain medication. An opioid is sometimes called a narcotic.
Codeine (Benadryl Capsules, Austria) is used to treat mild to moderately severe pain.
Codeine (Benadryl Capsules, Austria) may also be used for purposes not listed in this medication guide.
Diphenhydramine (Benadryl Capsules, Austria) is an antihistamine. Diphenhydramine (Benadryl Capsules, Austria) blocks the effects of the naturally occurring chemical histamine in the body.
Diphenhydramine (Benadryl Capsules, Austria) is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.
Diphenhydramine (Benadryl Capsules, Austria) is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease.
Diphenhydramine (Benadryl Capsules, Austria) may also be used for purposes other than those listed in this medication guide.
An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough. [PubChem]
Diphenhydramine (Benadryl Capsules, Austria) is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Use Diphenhydramine (Benadryl Capsules, Austria) orally disintegrating strips as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Diphenhydramine (Benadryl Capsules, Austria) orally disintegrating strips.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled IndicationsPain management: Management of mild- to moderately-severe pain
Limitations of use: Reserve Codeine (Benadryl Capsules, Austria) for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwise inadequate.
Off Label UsesCough in select patients
In a metaanalysis of trials evaluating the treatment of chronic cough, the use of Codeine (Benadryl Capsules, Austria) demonstrated efficacy in patients with this condition.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Diphenhydramine (Benadryl Capsules, Austria) is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. It is also used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Diphenhydramine (Benadryl Capsules, Austria) can also be used to help you relax and fall asleep.
This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine).
Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.
These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
Diphenhydramine (Benadryl Capsules, Austria) is also used alone or with other medications to treat shaking (tremor) and muscle stiffness caused by Parkinson's disease. It may also be used to treat side effects of certain psychiatric drugs such as involuntary movements and muscle stiffness (such as EPS). It works by blocking acetylcholine.
How to use Diphenhydramine (Benadryl Capsules, Austria)Follow all directions on the product package. If your doctor has prescribed this medication, take it as directed. If you are uncertain about any of the information, consult your doctor or pharmacist.
Take the tablet, capsule, or liquid form by mouth with or without food. Measure liquid forms of this medication using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If you have a single-dose form of this medication (such as a single-use whistle), you do not need to measure the dose.
The rapidly-dissolving tablet or strip should be allowed to dissolve on the tongue and then swallowed, with or without water. The chewable tablets should be chewed thoroughly before being swallowed.
The dosage is based on your age, medical condition, and response to treatment. There are many brands and forms of Diphenhydramine (Benadryl Capsules, Austria) available. Read the dosing instructions carefully for each product because the amount of Diphenhydramine (Benadryl Capsules, Austria) may be different between products. Do not increase your dose or take this medication more often than directed.
To prevent motion sickness, take your dose 30 minutes before starting activity such as travel. To help you sleep, take your dose about 30 minutes before bedtime. If you continue to have difficulty sleeping for longer than 2 weeks, contact your doctor.
Tell your doctor if your condition does not improve or if it worsens.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Tablet,
Oral, as sulfate:Generic: 15 mg, 30 mg, 60 mg
Dosing: Adult
Pain management (analgesic):
Injection [Canadian product]:
Opioid-naive patients: IM, SubQ: 30 to 60 mg every 4 to 6 hours as needed (use the lowest effective dose for the shortest period of time necessary)
Conversion from oral Codeine (Benadryl Capsules, Austria) or another opioid: IM, SubQ: Refer to product labeling for dose conversions.
Oral: Note: These are guidelines and do not represent the maximum doses that may be required in all patients. Doses should be titrated to pain relief/prevention.
Immediate release (tablet, oral solution [Canadian product]): Initial: 15 to 60 mg every 4 hours as needed; maximum total daily dose: 360 mg/day; patients with prior opioid exposure may require higher initial doses. Note: The American Pain Society recommends an initial dose of 30 to 60 mg for adults with moderate pain (American Pain Society 2016).
Controlled release: Codeine (Benadryl Capsules, Austria) Contin [Canadian product]: Note: Titrate at intervals of ≥48 hours until adequate analgesia has been achieved. Daily doses >600 mg/day should not be used; patients requiring higher doses should be switched to an opioid approved for use in severe pain. In patients who receive both Codeine (Benadryl Capsules, Austria) Contin and an immediate release or combination Codeine (Benadryl Capsules, Austria) product for breakthrough pain, the rescue dose of immediate release Codeine (Benadryl Capsules, Austria) product should be ≤12.5% of the total daily Codeine (Benadryl Capsules, Austria) Contin dose.
Opioid-naive patients: Initial: 50 mg every 12 hours
Conversion from immediate release Codeine (Benadryl Capsules, Austria) preparations: Immediate release Codeine (Benadryl Capsules, Austria) preparations contain ~75% Codeine (Benadryl Capsules, Austria) base. Therefore, patients who are switching from immediate release Codeine (Benadryl Capsules, Austria) preparations may be transferred to a ~25% lower total daily dose of Codeine (Benadryl Capsules, Austria) Contin, equally divided into 2 daily doses every 12 hours.
Conversion from a combination Codeine (Benadryl Capsules, Austria) product (eg, Codeine (Benadryl Capsules, Austria) with acetaminophen or aspirin): See table:
Conversion from another opioid analgesic: Using the patient's current opioid dose, calculate an equivalent daily dose of immediate release Codeine (Benadryl Capsules, Austria). A ~25% lower dose of Codeine (Benadryl Capsules, Austria) Contin should then be initiated, equally divided into 2 daily doses.
Discontinuation of therapy: When discontinuing chronic opioid therapy, the dose should be gradually tapered down. An optimal universal tapering schedule for all patients has not been established (CDC [Dowell 2016]). Proposed schedules range from slow (eg, 10% reductions per week) to rapid (eg, 25% to 50% reduction every few days) (CDC 2015). Tapering schedules should be individualized to minimize opioid withdrawal while considering patient-specific goals and concerns as well as the pharmacokinetics of the opioid being tapered. An even slower taper may be appropriate in patients who have been receiving opioids for a long duration (eg, years), particularly in the final stage of tapering, whereas more rapid tapers may be appropriate in patients experiencing severe adverse events (CDC [Dowell 2016]). Monitor carefully for signs/symptoms of withdrawal. If the patient displays withdrawal symptoms, consider slowing the taper schedule; alterations may include increasing the interval between dose reductions, decreasing amount of daily dose reduction, pausing the taper and restarting when the patient is ready, and/or coadministration of an alpha-2 agonist (eg, clonidine) to blunt withdrawal symptoms (Berna 2015; CDC [Dowell 2016]). Continue to offer nonopioid analgesics as needed for pain management during the taper; consider nonopioid adjunctive treatments for withdrawal symptoms (eg, GI complaints, muscle spasm) as needed (Berna 2015; Sevarino 2018).
Cough in select patients (off-label use):
Oral: Reported doses vary with a range of 7.5 to 120 mg/day as a single dose or in divided doses; however, evidence is of low quality (ACCP [Bolser 2006]; Smith 2010). Some experts recommend 30 to 60 mg 4 times daily in specific patient populations (eg, lung cancer) (ACCP [Molassiotis 2017]). Additional data may be necessary to further define the role of Codeine (Benadryl Capsules, Austria) in this condition.
Diarrhea (persistent) (palliative care) (off-label use):
Oral: 15 to 30 mg every 4 hours as needed (von Gunten 2013). Additional data may be necessary to further define the role of Codeine (Benadryl Capsules, Austria) in this condition.
Restless leg syndrome (off-label use):
Oral: Initial: 30 mg once daily at bedtime or during the night; may increase to 60 mg if needed; maximum dose: 180 mg in 2 to 3 divided doses. May be used alone or in combination with other medications used to treat RLS (Earley 2003; Sandyk 1987; Silbers 2013; Walters 2001).
Dosing: Geriatric
Refer to adult dosing. Use with caution and consider initiation at the low end of the dosing range; reduced initial dosages may be necessary.
Dosing: Pediatric
Note: Codeine (Benadryl Capsules, Austria) 30 mg/5 mL oral solution has been discontinued in the US for more than 1 year. Doses should be titrated to appropriate analgesic effect; use the lowest effective dose for the shortest period of time:
Pain management; analgesia: Limited data available: Note: Use is contraindicated in pediatric patients <12 years of age and for postoperative management in pediatric patients 12 to 18 years of age who have undergone tonsillectomy and/or adenoidectomy. Avoid Codeine (Benadryl Capsules, Austria) use in all pediatric patient populations in which it is contraindicated and in pediatric patients 12 to 18 years of age who have other risk factors that increase risk for respiratory depression associated with Codeine (Benadryl Capsules, Austria) (eg, conditions associated with hypoventilation like postoperative status, obstructive sleep apnea, obesity, severe pulmonary disease, neuromuscular disease, use of other medications known to depress respiratory drive); in rare cases in which Codeine (Benadryl Capsules, Austria)-containing product is the only option, consider genotype testing prior to use; use extra precaution; monitor closely for adverse effects. Codeine (Benadryl Capsules, Austria) has been associated with reports of life-threatening or fatal respiratory depression in children and adolescents; multifactorial causes have been identified; of primary concern are unrecognized ultrarapid metabolizers of CYP2D6 who may have extensive conversion of Codeine (Benadryl Capsules, Austria) (prodrug) to morphine and thus increased opioid-mediated effects. Avoid Codeine (Benadryl Capsules, Austria) use in pediatric patient populations in which it is contraindicated; in rare cases in which Codeine (Benadryl Capsules, Austria)-containing product is the only option, consider genotype testing prior to use; use extra precaution; monitor closely for adverse effects (AAP [Tobias 2016]; Dancel 2017; Gammal 2016; Goldschneider 2017; Poonai 2015).
Children and Adolescents:
Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed; maximum single dose: 60 mg/dose (APS 2016)
Usual Adult Dose for InsomniaNote: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Pain
Note: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Adult Dose for Headache
Note: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Insomnia
Greater than or equal to 12 years:
Note: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Pain
Greater than or equal to 12 years:
Note: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Usual Pediatric Dose for Headache
Greater than or equal to 12 years:
Note: Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) is generally dosed based on the Diphenhydramine (Benadryl Capsules, Austria) component to equal 50 mg of Diphenhydramine (Benadryl Capsules, Austria) (76 mg Diphenhydramine (Benadryl Capsules, Austria) citrate) at bedtime.
Acetaminophen-Diphenhydramine (Benadryl Capsules, Austria) comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution in patients with liver disease. Chronic use of acetaminophen is not recommended in patients with liver disease.
Precautions
Patients who consume three or more alcohol containing drinks per day should be informed to consult with their physician for advice on when and how to take acetaminophen. Chronic, heavy alcohol users may be at increased risk of liver damage when taking more than recommended dosages.
Patients and adults taking care of children should be advised to consult with their doctor before continuing to use acetaminophen if symptoms of illness worsen. Although rare, there is the possibility of acetaminophen intoxication on chronic use of the drug, and the symptoms seen during the first phase of intoxication (nausea, vomiting, anorexia, malaise, and diaphoresis) may trigger the use of more doses.
Patients should be warned of the sedative effects of Diphenhydramine (Benadryl Capsules, Austria), and advised not to take this drug with alcohol.
Due to the anticholinergic effect of Diphenhydramine (Benadryl Capsules, Austria), it should be used with caution in patients with narrow-angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, prostatic hypertrophy or bladder neck obstructions. It should also be used with caution in patients with increased intraocular pressure, hyperthyroidism, cardiovascular disease, or hypertension.
Dialysis
Data not available
See also:
What other drugs will affect Codeine (Benadryl Capsules, Austria)?
When this drug applied simultaneously with:
- drugs have a depressing effect on the central nervous system (including those with opioid analgesics, barbiturates, benzodiazepines, clonidine) it is possible an increase the action of Codeine (Benadryl Capsules, Austria).
- derivatives of morphine it may increased the inhibitory action on the respiratory center; ibuprofen - analgesic effect is enhanced; carbamazepine - it may increased the analgesic effect is apparently due to increased formation of Codeine (Benadryl Capsules, Austria) metabolite normorphine, which has a stronger effect.
- quinidine the analgesic effect of Codeine (Benadryl Capsules, Austria) decreased or almost disappeared.
- Codeine (Benadryl Capsules, Austria) increases the effect of ethanol on psychomotor function.
See also:
What other drugs will affect Diphenhydramine (Benadryl Capsules, Austria)?
Most reports of clinically significant drug interactions occurring with the barbiturates have involved phenobarbital
1. Anticoagulants: Diphenhydramine (Benadryl Capsules, Austria) lowers the plasma levels of dicumarol (name previously used: bishydorxycoumarin) and causes a decrease in anticoagulant activity as measured by the prothrombin time. Diphenhydramine (Benadryl Capsules, Austria) can induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response of oral anticoagulants (e.g., warfarin, acenocournarol, dicumarol, and phenprocoumon). Patients stabilized on anticoagulant therapy may require dosage adjustments if phenobarbital is added to or withdrawn from their dosage regimen
2. Corticosteroids: Diphenhydramine (Benadryl Capsules, Austria) appears to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if phenobarbital is added to or withdrawn from their dosage regimen.
3. Griseofulvin: Diphenhydramine (Benadryl Capsules, Austria) appears to interfere with the absorption of orally administered griseofulvin, thus decreasing its blood level. The effect of the resultant decreased blood levels of griseofulvin on therapeutic response has not been established. However, it would be preferable to avoid concomitant administration of these drugs.
4. Doxycycline: Diphenhydramine (Benadryl Capsules, Austria) has been shown to shorten the half- life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the clinical response to doxycycline should be monitored closely
5. Phenytoin, sodium valproate, valproic acid: The effect of phenobarbital on the metabolism of phenytoin appears to be variable. Some investigators report an accelerating effect, while others report no effect. Because the effect of phenobarbital on the metabolism of phenytoin is not predictable, phenytoin and phenobarbital blood levels should be monitored more frequently if these drugs are given concurrently. Sodium valproate and valproic acid appear to decrease phenobarbital metabolism; therefore, phenobarbital blood levels should be monitored and appropriate dosage adjustments made as indicated.
6. Central nervous system depressants: The concomitant use of other central nervous system depressants including other sedatives or hypnotics, antihistamines, tranquilizers, or alcohol, may produce additive depressant effects
7. Monoamine oxidase inhibitors (MAOIs): MAOIs prolong the effects of phenobarbital probably because metabolism of the phenobarbital is inhibited.
8. Estradiol, estrone, progesterone and other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital may decrease the effect of estradiol by increasing its metabolism. There have been reports of patients treated with antiepileptic drugs (e.g., phenobarbital) who became pregnant while taking oral contraceptives. An alternate contraceptive method might be suggested to women taking phenobarbital.
